Search Results - "Waller, Rachel"

Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS) by Waller, Rachel, Goodall, Emily F, Milo, Marta, Cooper-Knock, Jonathan, Da Costa, Marc, Hobson, Esther, Kazoka, Mbombe, Wollff, Helen, Heath, Paul R, Shaw, Pamela J, Kirby, Janine

“…Abstract Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative condition characterised by loss of motor neurones and progressive muscle wasting…”
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Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach by Huh, Won Jae, Khurana, Shradha S, Geahlen, Jessica H, Kohli, Kavita, Waller, Rachel A, Mills, Jason C

“…Tamoxifen, a selective estrogen receptor modulator, is widely used in research and clinically in patients. We find that treatment of normal mice with a single…”
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Small RNA Sequencing of Sporadic Amyotrophic Lateral Sclerosis Cerebrospinal Fluid Reveals Differentially Expressed miRNAs Related to Neural and Glial Activity by Waller, Rachel, Wyles, Matthew, Heath, Paul R, Kazoka, Mbombe, Wollff, Helen, Shaw, Pamela J, Kirby, Janine

“…Amyotrophic lateral sclerosis (ALS) is a clinical subtype of motor neurone disease (MND), a fatal neurodegenerative disease involving the loss of both the…”
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Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions by Waller, Rachel, Baxter, Lynne, Fillingham, Daniel J, Coelho, Santiago, Pozo, Jose M, Mozumder, Meghdoot, Frangi, Alejandro F, Ince, Paul G, Simpson, Julie E, Highley, J Robin

“…Deep subcortical lesions (DSCL) of the brain, are present in ~60% of the ageing population, and are linked to cognitive decline and depression. DSCL are…”
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The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood-Brain Barrier Dysfunction by Almansouri, Taghreed, Waller, Rachel, Wharton, Stephen B, Heath, Paul R, Matthews, Fiona E, Brayne, Carol, van Eeden, Fredericus, Simpson, Julie E

“…Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68 microglia. This study…”
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Histological characterization of interneurons in Alzheimer's disease reveals a loss of somatostatin interneurons in the temporal cortex by Waller, Rachel, Mandeya, Memory, Viney, Edward, Simpson, Julie E., Wharton, Stephen B.

“…Neuronal dysfunction and synaptic loss are major hallmarks of Alzheimer's disease (AD) which correlate with symptom severity. Impairment of the γ‐aminobutyric…”
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The genetics of amyotrophic lateral sclerosis: current insights by Alsultan, Afnan A, Waller, Rachel, Heath, Paul R, Kirby, Janine

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that results in loss of the upper and lower motor neurons from motor cortex,…”
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NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain by Fadul, Motaz M, Garwood, Claire J, Waller, Rachel, Garrett, Navonna, Heath, Paul R, Matthews, Fiona E, Brayne, Carol, Wharton, Stephen B, Simpson, Julie E

“…Astrocytes play a major role in the pathogenesis of a range of neurodegenerative diseases, including Alzheimer's disease (AD), undergoing dramatic…”
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Interprofessional Team-Based Learning Module: Chronic Non-Cancer Pain by Bishop, Steven, Waller, Rachel, Sicat, Brigitte, Morgan, Laura, Lee, Bennett, Lord, Benjamin, Yanni, Leanne

“…Abstract This resource is an interprofessional education (IPE) module which uses team-based learning as an instructional strategy to teach internal medicine…”
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Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke by Hase, Yoshiki, Ameen‐Ali, Kamar E., Waller, Rachel, Simpson, Julie E., Stafford, Charlotte, Mahesh, Ayushi, Ryan, Lucy, Pickering, Lucy, Bodman, Caroline, Hase, Mai, Boche, Delphine, Horsburgh, Karen, Wharton, Stephen B., Kalaria, Raj N.

“…With the hypothesis that perivascular microglia are involved as neuroinflammatory components of the gliovascular unit contributing to white matter…”
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Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain by Waller, Rachel, Murphy, Mark, Garwood, Claire J, Jennings, Luke, Heath, Paul R, Chambers, Annabelle, Matthews, Fiona E, Brayne, Carol, Ince, Paul G, Wharton, Stephen B, Simpson, Julie E

“…Oxidative stress and oxidative DNA damage are early features of mild cognitive impairment and Alzheimer's disease (AD), occurring before the formation of…”
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The Impact of Integrated Psychological Services in a Safety Net Primary Care Clinic on Medical Utilization by Lanoye, Autumn, Stewart, Karen E., Rybarczyk, Bruce D., Auerbach, Stephen M., Sadock, Elizabeth, Aggarwal, Arpita, Waller, Rachel, Wolver, Susan, Austin, Kristin

“…Objective The integration of psychological and behavioral health services into safety net primary care clinics has been viewed as a step toward reducing…”
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Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies by Waller, Rachel, Narramore, Ruth, Simpson, Julie E., Heath, Paul R., Verma, Nikita, Tinsley, Megan, Barnes, Jordan R., Haris, Hanna T., Henderson, Frances E., Matthews, Fiona E., Richardson, Connor D., Brayne, Carol, Ince, Paul G., Kalaria, Raj N., Wharton, Stephen B.

“…White matter lesions (WML) are common in the ageing brain, often arising in a field effect of diffuse white matter abnormality. Although WML are associated…”
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Iba-1.sup.-/CD68.sup.+ microglia are a prominent feature of age-associated deep subcortical white matter lesions by Waller, Rachel, Baxter, Lynne, Fillingham, Daniel J, Coelho, Santiago, Pozo, Jose M, Mozumder, Meghdoot, Frangi, Alejandro F, Ince, Paul G, Simpson, Julie E, Highley, J. Robin

“…Deep subcortical lesions (DSCL) of the brain, are present in ~60% of the ageing population, and are linked to cognitive decline and depression. DSCL are…”
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Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role by Waller, Rachel, Woodroofe, M. Nicola, Wharton, Stephen B, Ince, Paul G, Francese, Simona, Heath, Paul R, Cudzich-Madry, Alex, Thomas, Ruth H, Rounding, Natalie, Sharrack, Basil, Simpson, Julie E

“…Abstract Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). White matter lesions in MS are…”
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Transcriptomic Profiling Reveals Discrete Poststroke Dementia Neuronal and Gliovascular Signatures by Waller, Rachel, Hase, Yoshiki, Simpson, Julie E., Heath, Paul R., Wyles, Matthew, Kalaria, Rajesh N., Wharton, Stephen B.

“…Poststroke dementia (PSD) is associated with pathology in frontal brain regions, in particular dorsolateral prefrontal cortex (DLPFC) neurons and white matter,…”
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From use of omics to systems biology: Identifying therapeutic targets for amyotrophic lateral sclerosis by Castelli, Lydia, Vasta, Rosario, Allen, Scott P, Waller, Rachel, Chiò, Adriano, Traynor, Bryan J, Kirby, Janine

“…Amyotrophic lateral sclerosis (ALS) is a heterogeneous progressive neurodegenerative disorder with available treatments such as riluzole and edaravone…”
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Change implementation: the association of adaptive reserve and burnout among inpatient medicine physicians and nurses by Huynh, Christine, Bowles, Darci, Yen, Miao-Shan, Phillips, Allison, Waller, Rachel, Hall, Lindsey, Tu, Shin-Ping

“…Adaptive Reserve (AR) is positively associated with implementing change in ambulatory settings. Deficits in AR may lead to change fatigue or burnout. We…”
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Establishing mRNA and microRNA interactions driving disease heterogeneity in amyotrophic lateral sclerosis patient survival by Waller, Rachel, Bury, Joanna J, Appleby-Mallinder, Charlie, Wyles, Matthew, Loxley, George, Babel, Aditi, Shekari, Saleh, Kazoka, Mbombe, Wollff, Helen, Al-Chalabi, Ammar, Heath, Paul R, Shaw, Pamela J, Kirby, Janine

“…Abstract Amyotrophic lateral sclerosis is a fatal neurodegenerative disease, associated with the degeneration of both upper and lower motor neurons of the…”
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Connecting the Dots: An Interdisciplinary Diabetes Quality Improvement Initiative by Waller, Rachel, Koehn, Deborah, Miller, Susan, Thurby-Hay, Linda, Le, Trang

“…"Quality Improvement Success Stories" are published by the American Diabetes Association in collaboration with the American College of Physicians, Inc., and…”
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