Search Results - "Waller, Kimberly A."
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The biology of Lubricin: Near frictionless joint motion
Published in Matrix biology (01-10-2014)“…Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints,…”
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Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis
Published in Proceedings of the National Academy of Sciences - PNAS (09-04-2013)“…Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death,…”
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Intra-articular Recombinant Human Proteoglycan 4 Mitigates Cartilage Damage After Destabilization of the Medial Meniscus in the Yucatan Minipig
Published in The American journal of sports medicine (01-06-2017)“…Background: Lubricin, or proteoglycan 4 (PRG4), is a glycoprotein responsible for joint boundary lubrication. PRG4 has been shown previously to be…”
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Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice
Published in International journal of molecular sciences (11-06-2017)“…Deficiency of PRG4 (lubricin), the boundary lubricant in mammalian joints, contributes to increased joint friction accompanied by superficial and upper…”
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Lubricin Restoration in a Mouse Model of Congenital Deficiency
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-11-2015)“…Objective Congenital deficiency of the principal boundary lubricant in cartilage (i.e., lubricin, encoded by the gene PRG4) increases joint friction and causes…”
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Transcriptional profiling of articular cartilage in a porcine model of early post‐traumatic osteoarthritis
Published in Journal of orthopaedic research (01-01-2018)“…ABSTRACT To identify the molecular pathophysiology present in early post‐traumatic osteoarthritis (PTOA), the transcriptional profile of articular cartilage…”
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Transcriptional profiling of synovium in a porcine model of early post‐traumatic osteoarthritis
Published in Journal of orthopaedic research (01-08-2018)“…ABSTRACT To determine the transcriptional profile of synovium during the molecular phase of post‐traumatic osteoarthritis, anterior cruciate ligament…”
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Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis
Published in Arthritis research & therapy (14-03-2016)“…Lubricin, a mucinous glycoprotein secreted by synoviocytes and chondrocytes plays an important role in reducing the coefficient of friction in mammalian…”
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Preventing Friction-induced Chondrocyte Apoptosis: Comparison of Human Synovial Fluid and Hylan G-F 20
Published in Journal of rheumatology (01-07-2012)“…Symptomatic osteoarthritis (OA) is a common painful disease with limited treatment options. A rising number of patients with OA have been treated with…”
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Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection
Published in Arthritis and rheumatism (01-08-2010)“…Objective To investigate whether cartilage degeneration is prevented or minimized following intraarticular injections of lubricin derived from human…”
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Using a Symbolic Interactionist Approach to Role and Identity to Illuminate Medical Student Avoidance of Primary Care
Published in International quarterly of community health education (01-01-2011)“…A symbolic interactionist approach is presented and analyzed in reference to helping solve the problem of medical students not choosing primary care practice…”
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