Search Results - "Waller, E."

Identification of multiple genomic DNA sequences which form i-motif structures at neutral pH by Wright, Elisé P, Huppert, Julian L, Waller, Zoë A E

“…i-Motifs are alternative DNA secondary structures formed in cytosine-rich sequences. Particular examples of these structures, traditionally assumed to be…”
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EMS injury cause codes more accurate than emergency department visit ICD-10-CM codes for firearm injury intent in North Carolina by Snyder, Nicole L, Ising, Amy, Waller, Anna E

“…The timeliness, accuracy, and completeness of data for firearm injury surveillance is crucial for public health surveillance efforts and informing injury…”
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Beyond Solvent Exclusion: i‑Motif Detecting Capability and an Alternative DNA Light-Switching Mechanism in a Ruthenium(II) Polypyridyl Complex by Spence, Philip, Fielden, John, Waller, Zoë. A. E

“…Cytosine-rich DNA can fold into secondary structures known as i-motifs. Mounting experimental evidence suggests that these non-canonical nucleic acid…”
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The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis by Waller, Natalie J. E., Cheung, Chen-Yi, Cook, Gregory M., McNeil, Matthew B.

“…The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished the efficacy of almost all available antibiotics, complicating efforts…”
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Mechanistic Insights into the Ligand-Induced Unfolding of an RNA G‑Quadruplex by Haldar, Susanta, Zhang, Yashu, Xia, Ying, Islam, Barira, Liu, Sisi, Gervasio, Francesco L, Mulholland, Adrian J, Waller, Zoë A. E, Wei, Dengguo, Haider, Shozeb

“…The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand that can stabilize different topologies via multiple binding modes…”
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QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene by Alexandrou, Effrosyni, Guneri, Dilek, Neidle, Stephen, Waller, Zoë A E

“…GC-rich sequences can fold into G-quadruplexes and i-motifs and are known to control gene expression in many organisms. The potent G-quadruplex experimental…”
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DNA G‑Quadruplex and i‑Motif Structure Formation Is Interdependent in Human Cells by King, Jessica J, Irving, Kelly L, Evans, Cameron W, Chikhale, Rupesh V, Becker, Rouven, Morris, Christopher J, Peña Martinez, Cristian D, Schofield, Peter, Christ, Daniel, Hurley, Laurence H, Waller, Zoë A. E, Iyer, K. Swaminathan, Smith, Nicole M

“…Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show…”
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Structural insights into i-motif DNA structures in sequences from the insulin-linked polymorphic region by Guneri, Dilek, Alexandrou, Effrosyni, El Omari, Kamel, Dvořáková, Zuzana, Chikhale, Rupesh V., Pike, Daniel T. S., Waudby, Christopher A., Morris, Christopher J., Haider, Shozeb, Parkinson, Gary N., Waller, Zoë A. E.

“…The insulin-linked polymorphic region is a variable number of tandem repeats region of DNA in the promoter of the insulin gene that regulates transcription of…”
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Epigenetic modification of cytosines fine tunes the stability of i-motif DNA by Wright, Elisé P, Abdelhamid, Mahmoud A S, Ehiabor, Michelle O, Grigg, Melanie C, Irving, Kelly, Smith, Nicole M, Waller, Zoë A E

“…i-Motifs are widely used in nanotechnology, play a part in gene regulation and have been detected in human nuclei. As these structures are composed of…”
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A solar-driven atmospheric water extractor for off-grid freshwater generation and irrigation by Yang, Kaijie, Pan, Tingting, Ferhat, Nadia, Felix, Alejandra Ibarra, Waller, Rebekah E., Hong, Pei-Ying, Vrouwenvelder, Johannes S., Gan, Qiaoqiang, Han, Yu

“…Solar-driven atmospheric water extraction (SAWE) is a sustainable technology for decentralized freshwater supply. However, most SAWE systems produce water…”
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Statewide declines in myocardial infarction and stroke emergency department visits during COVID-19 restrictions in North Carolina by Wong, Eugenia, Rosamond, Wayne, Patel, Mehul D., Waller, Anna E.

“…[...]these studies relied primarily on data from select health systems or medical groups and few reported on the impact of the pandemic past May 2020. Based on…”
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Destabilization of i‑Motif DNA at Neutral pH by G‑Quadruplex Ligands by Abdelhamid, Mahmoud A. S, Gates, Andrew J, Waller, Zoë A. E

“…Numerous studies have been published stressing the importance of finding ligands that can bind specifically to DNA secondary structures. Several have…”
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Clostridioides difficile outbreak detection: Evaluation by ribotyping and whole-genome sequencing of a surveillance algorithm based on ward-specific cutoffs by Edman-Wallér, Jon E., Toepfer, Michael, Karp, Johan, Rizzardi, Kristina, Jacobsson, Gunnar, Werner, Maria

“…We evaluated the performance of an early-warning algorithm, based on ward-specific incidence cutoffs for detecting transmission in hospitals. We also sought to…”
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The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer by Ahmed, Ahmed A, Greenhalf, William, Palmer, Daniel H, Williams, Nicole, Worthington, Jenny, Arshad, Tariq, Haider, Shozeb, Alexandrou, Effrosyni, Guneri, Dilek, Waller, Zoe A E, Neidle, Stephen

“…The naphthalene diimide compound QN-302, designed to bind to G-quadruplex DNA sequences within the promoter regions of cancer-related genes, has high…”
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Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties by Bertrand, Benoît, Fernandez-Cestau, Julio, Angulo, Jesus, Cominetti, Marco M. D, Waller, Zoë A. E, Searcey, Mark, O’Connell, Maria A, Bochmann, Manfred

“…The synthesis of a series of cyclometalated gold­(III) complexes supported by pyrazine-based (C^N^C)-type pincer ligands is reported, including the crystal…”
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Detecting Clostridium difficile outbreaks with ward-specific cut-off levels based on the Poisson distribution by Edman-Wallér, Jon E, Werner, Maria

“…Outbreaks often occur either as a general increase in incidence on the hospital level, or as a cluster of cases within a single ward. At the wards in our…”
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Identification of new DNA i-motif binding ligands through a fluorescent intercalator displacement assay by Sheng, Qiran, Neaverson, Joseph C, Mahmoud, Tasnim, Stevenson, Clare E M, Matthews, Susan E, Waller, Zoë A E

“…i-Motifs are quadruplex DNA structures formed from sequences rich in cytosine and held together by intercalated, hemi-protonated cytosine-cytosine base pairs…”
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Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4 by Belair, David G., Lu, Gang, Waller, Laura E., Gustin, Jason A., Collins, Nathaniel D., Kolaja, Kyle L.

“…Exposure to thalidomide during a critical window of development results in limb defects in humans and non-human primates while mice and rats are refractory to…”
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G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulate c-KIT Expression in Human Gastric Carcinoma Cells by McLuckie, Keith I. E, Waller, Zoë A. E, Sanders, Deborah A, Alves, David, Rodriguez, Raphaël, Dash, Jyotirmayee, McKenzie, Grahame J, Venkitaraman, Ashok R, Balasubramanian, Shankar

“…There is considerable interest in the structure and function of G-quadruplex nucleic acid secondary structures, their cellular functions, and their potential…”
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Bovine TB infection status in cattle in Great Britain in 2021 by Voller, C, Brouwer, A, Upton, PA, Waller, ESL, Duncan, D, Harris, KA, Marriott, E, Avigad, R

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