Search Results - "Wallen, Mark C."

Redesigning Recombinase Specificity for Safe Harbor Sites in the Human Genome by Wallen, Mark C, Gaj, Thomas, Barbas, 3rd, Carlos F

“…Site-specific recombinases (SSRs) are valuable tools for genetic engineering due to their ability to manipulate DNA in a highly specific manner. Engineered…”
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Highly active zinc-finger nucleases by extended modular assembly by Bhakta, Mital S, Henry, Isabelle M, Ousterout, David G, Das, Kumitaa Theva, Lockwood, Sarah H, Meckler, Joshua F, Wallen, Mark C, Zykovich, Artem, Yu, Yawei, Leo, Heather, Xu, Lifeng, Gersbach, Charles A, Segal, David J

“…Zinc-finger nucleases (ZFNs) are important tools for genome engineering. Despite intense interest by many academic groups, the lack of robust noncommercial…”
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Improved Cell-Penetrating Zinc-Finger Nuclease Proteins for Precision Genome Engineering by Liu, Jia, Gaj, Thomas, Wallen, Mark C, Barbas, Carlos F

“…Safe, efficient, and broadly applicable methods for delivering site-specific nucleases into cells are needed in order for targeted genome editing to reach its…”
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Enhancing the Specificity of Recombinase-Mediated Genome Engineering through Dimer Interface Redesign by Gaj, Thomas, Sirk, Shannon J, Tingle, Ryan D, Mercer, Andrew C, Wallen, Mark C, Barbas, Carlos F

“…Despite recent advances in genome engineering made possible by the emergence of site-specific endonucleases, there remains a need for tools capable of…”
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Reducing Patient Restraints: A Pilot Approach Using Clinical Case Review by Sclafani, Michael J., Humphrey II, Frederick J., Repko, Sharon, Ko, Haeng S., Wallen, Mark C., DiGiacomo, Albert

“…PURPOSE.  This study aims to reduce the incidents of restraints by applying a nontraditional consultation process in which a university‐based team focused on…”
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Combined buprenorphine and chlonidine for short-term opiate detoxification: patient perspectives by Wallen, Mark C, Lorman, William J, Gosciniak, Joyce L

“…The approval in 2003 for the use of buprenorphine in opiate addiction treatment has provided physicians with a new pharmacological tool to combat opiate…”
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Combined Buprenorphine and Clonidine for Short-Term Opiate Detoxification: Patient Perspectives by Wallen, Mark C., Lorman, William J., Gosciniak, Joyce L.

“…The approval in 2003 for the use of buprenorphine in opiate addiction treatment has provided physicians with a new pharmacological tool to combat opiate…”
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Redesigning Recombinase Specificity for Safe Harbor Sites in the Human Genome: e0139123 by Wallen, Mark C, Gaj, Thomas, Barbas, Carlos F

“…Site-specific recombinases (SSRs) are valuable tools for genetic engineering due to their ability to manipulate DNA in a highly specific manner. Engineered…”
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Culture and social class as intervening variables in relapse prevention with chemically dependent women by Weiner, H D, Wallen, M C, Zankowski, G L

“…Craving and relapse are complex, poorly understood phenomena. A distinctive and baffling characteristic of the disease of chemical dependency is the continuing…”
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Impediments to effective treatment of the dually diagnosed patient by Wallen, M C, Weiner, H D

“…Mental health and chemical dependency clinicians have differing beliefs in regard to the etiology, diagnosis, and treatment of dually diagnosed patients. The…”
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Utilization of 12-step theme groups in a short-term chemical dependence treatment unit by Wallen, M C, Weiner, H D, Mansi, A, Deal, D

“…At Eagleville Hospital, staff have found that utilizing the theme-group process facilitates patient acceptance of 12-Step programs within a relatively short…”
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