Search Results - "Wallace, Maura"

Dual-Site Regulation of MDM2 E3-Ubiquitin Ligase Activity by Wallace, Maura, Worrall, Erin, Pettersson, Susanne, Hupp, Ted R., Ball, Kathryn L.

“…The control of p53 ubiquitination by MDM2 provides a model system to define how an E3-ligase functions on a conformationally flexible substrate. The mechanism…”
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MDM2 Chaperones the p53 Tumor Suppressor by Wawrzynow, Bartosz, Zylicz, Alicja, Wallace, Maura, Hupp, Ted, Zylicz, Maciej

“…The murine double minute (mdm2) gene encodes an E3 ubiquitin ligase that plays a key role in the degradation of p53 tumor suppressor protein. Nevertheless…”
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Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2 by Pettersson, Susanne, Kelleher, Michael, Pion, Emmanuelle, Wallace, Maura, Ball, Kathryn L

“…Mdm2 (murine double minute 2)-mediated ubiquitination of the p53 tumour suppressor requires interaction of the ligase at two distinct binding sites that form…”
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Interferon Regulatory Factor 1 Binding to p300 Stimulates DNA-Dependent Acetylation of p53 by Dornan, David, Eckert, Mirjam, Wallace, Maura, Shimizu, Harumi, Ramsay, Eleanor, Hupp, Ted R., Ball, Kathryn L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo by Shimizu, Harumi, Burch, Lindsay R, Smith, Amanda J, Dornan, David, Wallace, Maura, Ball, Kathryn L, Hupp, Ted R

“…Although the N-terminal BOX-I domain of the tumor suppressor protein p53 contains the primary docking site for MDM2, previous studies demonstrated that RNA…”
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Docking-Dependent Regulation of the Rb Tumor Suppressor Protein by Cdk4 by Wallace, Maura, Ball, Kathryn L.

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Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway by Pettersson, Susanne, Sczaniecka, Matylda, McLaren, Lorna, Russell, Fiona, Gladstone, Karen, Hupp, Ted, Wallace, Maura

“…The Notch receptor is necessary for modulating cell fate decisions throughout development, and aberrant activation of Notch signalling has been associated with…”
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MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism by Sczaniecka, Matylda, Gladstone, Karen, Pettersson, Susanne, McLaren, Lorna, Huart, Anne-Sophie, Wallace, Maura

“…The E3 ubiquitin ligase, MDM2, uses a dual-site mechanism to ubiquitinate and degrade the tumor suppressor protein p53, involving interactions with the…”
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MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes by Hayashida, Kyoko, Kajino, Kiichi, Hattori, Masakazu, Wallace, Maura, Morrison, Ivan, Greene, Mark I., Sugimoto, Chihiro

“…Our efforts are concerned with identifying features of incomplete malignant transformation caused by non viral pathogens. Theileria parva (T. parva) is a…”
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MDM2 Protein-mediated Ubiquitination of NUMB Protein by Sczaniecka, Matylda, Gladstone, Karen, Pettersson, Susanne, McLaren, Lorna, Huart, Anne-Sophie, Wallace, Maura

“…The E3 ubiquitin ligase, MDM2, uses a dual-site mechanism to ubiquitinate and degrade the tumor suppressor protein p53, involving interactions with the…”
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Human herpesvirus-6B protein U19 contains a p53 BOX I homology motif for HDM2 binding and p53 stabilization by Kofod-Olsen, Emil, Pettersson, Susanne, Wallace, Maura, Abduljabar, Ahmed Basim, Øster, Bodil, Hupp, Ted, Höllsberg, Per

“…Abstract In order to establish a successful infection, it is of crucial importance for invading viruses to alter the activities of the regulatory protein p53…”
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ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1 by Stevens, Craig, Pettersson, Susanne, Wawrzynow, Bartosz, Wallace, Maura, Ball, Kathryn, Zylicz, Alicja, Hupp, Ted R

“…Murine double minute 2 (MDM2) protein exhibits many diverse biochemical functions on the tumour suppressor protein p53, including transcriptional suppression…”
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On the Mechanism of Sequence-specific DNA-dependent Acetylation of p53: The Acetylation Motif is Exposed upon DNA Binding by Češková, Pavla, Chichger, Havovi, Wallace, Maura, Vojtesek, Borek, Hupp, Ted R.

“…P53 acetylation requires p300-docking to two contiguous sites in the activation domain that in turn mediates DNA-dependent acetylation of the tetramer. In an…”
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Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo by Shimizu, Harumi, Saliba, David, Wallace, Maura, Finlan, Lee, Langridge-Smith, Patrick R R, Hupp, Ted R

“…p53 ubiquitination catalysed by MDM2 (murine double minute clone 2 oncoprotein) provides a biochemical assay to dissect stages in E3-ubiquitin-ligase-catalysed…”
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Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways by BLAYDES, J. P, CRAIG, A. L, WALLACE, M, BALL, H. M.-L, TRAYNOR, N. J, GIBBS, N. K, HUPP, T. R

“…High level activation of p53-dependent transcription occurs following cellular exposure to genotoxic damaging agents such as UV-C, while ionizing radiation…”
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The Conformationally Flexible S9–S10 Linker Region in the Core Domain of p53 Contains a Novel MDM2 Binding Site Whose Mutation Increases Ubiquitination of p53 in Vivo by Harumi Shimizu, Lindsay R. Burch, Amanda J. Smith, David Dornan, Maura Wallace, Kathryn L. Ball, Ted R. Hupp

“…Although the N-terminal BOX-I domain of the tumor suppressor protein p53 contains the primary docking site for MDM2, previous studies demonstrated that RNA…”
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Denaturing gradient gel electrophoresis: a novel method for determining Rh phenotype from genomic DNA by Steers, F, Wallace, M, Johnson, P, Carritt, B, Daniels, G

“…Denaturing gradient gel electrophoresis (DGGE) was carried out on PCR products amplified from exons 2 and 5 of RHD and RHCE. Exon 2 of RHD and exon 2 of the C…”
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Craniolateral approach to the humerus with transection of the brachialis muscle by Newton, G T

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Mechanical evaluation of three methods of plating distal radial osteotomies by Wallace, M K, Boudrieau, R J, Hyodo, K, Torzilli, P A

“…Eighteen intact canine cadaver radii underwent nondestructive axial testing, and were osteotomized, plated, and retested. Each bone was tested with and without…”
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Craniolateral approach to the humerus with transection of the brachialis muscle by Wallace, M K, Berg, J

“…Six fractures of the midshaft or distal third of the humerus were repaired through a modified craniolateral approach in which the brachialis muscle was…”
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