Search Results - "Wallace, Iain M"

Target prediction for an open access set of compounds active against Mycobacterium tuberculosis by Martínez-Jiménez, Francisco, Papadatos, George, Yang, Lun, Wallace, Iain M, Kumar, Vinod, Pieper, Ursula, Sali, Andrej, Brown, James R, Overington, John P, Marti-Renom, Marc A

“…Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects an estimated two billion people worldwide and is the leading cause of mortality…”
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A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans by Burns, Andrew R, Wallace, Iain M, Wildenhain, Jan, Tyers, Mike, Giaever, Guri, Bader, Gary D, Nislow, Corey, Cutler, Sean R, Roy, Peter J

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Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans by Luciani, Genna M, Magomedova, Lilia, Puckrin, Rachel, Urbanus, Malene L, Wallace, Iain M, Giaever, Guri, Nislow, Corey, Cummins, Carolyn L, Roy, Peter J

“…Dafadines, identified in a screen for compounds that induce the dauer phenotype in C. elegans , also promote longevity in adult worms, with both phenotypes…”
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Supervised multivariate analysis of sequence groups to identify specificity determining residues by Wallace, Iain M, Higgins, Desmond G

“…Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In…”
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Dark chemical matter as a promising starting point for drug lead discovery by Wassermann, Anne Mai, Lounkine, Eugen, Hoepfner, Dominic, Le Goff, Gaelle, King, Frederick J, Studer, Christian, Peltier, John M, Grippo, Melissa L, Prindle, Vivian, Tao, Jianshi, Schuffenhauer, Ansgar, Wallace, Iain M, Chen, Shanni, Krastel, Philipp, Cobos-Correa, Amanda, Parker, Christian N, Davies, John W, Glick, Meir

“…Unique activities and high potency at disease-relevant biological targets can now be identified for ‘dark chemical matter’—compounds in high-throughput…”
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Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases by Klein, Michael, Morillas, Montse, Vendrell, Alexandre, Brive, Lars, Gebbia, Marinella, Wallace, Iain M, Giaever, Guri, Nislow, Corey, Posas, Francesc, Grøtli, Morten

“…Highly selective, cell-permeable and fast-acting inhibitors of individual kinases are sought-after as tools for studying the cellular function of kinases in…”
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M-Coffee: combining multiple sequence alignment methods with T-Coffee by Wallace, Iain M., O'Sullivan, Orla, Higgins, Desmond G., Notredame, Cedric

“…We introduce M-Coffee, a meta-method for assembling multiple sequence alignments (MSA) by combining the output of several individual methods into one single…”
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A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans by Roy, Peter J, Burns, Andrew R, Wallace, Iain M, Wildenhain, Jan, Tyers, Mike, Giaever, Guri, Bader, Gary D, Nislow, Corey, Cutler, Sean R

“…Chemical screening in C. elegans is limited by the relatively poor target accessibility of small molecules. A systematic survey of drug-like small molecule…”
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Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples by Smith, Andrew M, Heisler, Lawrence E, St.Onge, Robert P, Farias-Hesson, Eveline, Wallace, Iain M, Bodeau, John, Harris, Adam N, Perry, Kathleen M, Giaever, Guri, Pourmand, Nader, Nislow, Corey

“…Next-generation sequencing has proven an extremely effective technology for molecular counting applications where the number of sequence reads provides a…”
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An integrated platform of genomic assays reveals small-molecule bioactivities by St Onge, Robert P, Nislow, Corey, Hoon, Shawn, M Smith, Andrew, Wallace, Iain M, Suresh, Sundari, Miranda, Molly, Fung, Eula, Proctor, Michael, Shokat, Kevan M, Zhang, Chao, Davis, Ronald W, Giaever, Guri

“…Bioactive compounds are widely used to modulate protein function and can serve as important leads for drug development. Identifying the in vivo targets of…”
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M-Coffee web server: a meta-method for computing multiple sequence alignments by combining alternative alignment methods by Moretti, Sebastien, Armougom, Fabrice, Wallace, Iain M, Higgins, Desmond G, Jongeneel, Cornelius V, Notredame, Cedric

“…The M-Coffee server is a web server that makes it possible to compute multiple sequence alignments (MSAs) by running several MSA methods and combining their…”
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CHEMGENIE: integration of chemogenomics data for applications in chemical biology by Kutchukian, Peter S., Chang, Charlie, Fox, Sean J., Cook, Erica, Barnard, Richard, Tellers, David, Wang, Huijun, Pertusi, Dante, Glick, Meir, Sheridan, Robert P., Wallace, Iain M., Wassermann, Anne Mai

“…•Ongoing efforts at our company to integrate and structure chemogenomics data are described.•The usefulness of a chemogenomics database for common applications…”
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PITPs as targets for selectively interfering with phosphoinositide signaling in cells by Nile, Aaron H, Tripathi, Ashutosh, Yuan, Peihua, Mousley, Carl J, Suresh, Sundari, Wallace, Iain M, Shah, Sweety D, Pohlhaus, Denise Teotico, Temple, Brenda, Nislow, Corey, Giaever, Guri, Tropsha, Alexander, Davis, Ronald W, St. Onge, Robert P, Bankaitis, Vytas A

“…Phosphatidylinositol transfer proteins (PITPs) are important mediators of phosphoinositide signaling within cells. A small-molecule inhibitor of the PITP…”
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Multiple sequence alignments by Wallace, Iain M, Blackshields, Gordon, Higgins, Desmond G

“…Multiple sequence alignments are very widely used in all areas of DNA and protein sequence analysis. The main methods that are still in use are based on…”
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Analysis and Comparison of Benchmarks for Multiple Sequence Alignment by Blackshields, Gordon, Wallace, Iain M., Larkin, Mark, Higgins, Desmond G.

“…The most popular way of comparing the performance of multiple sequence alignment programs is to use empirical testing on sets of test sequences. Several such…”
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Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans by Luciani, Genna M, Magomedova, Lilia, Puckrin, Rachel, Urbanus, Malene L, Wallace, Iain M, Giaever, Guri, Nislow, Corey, Cummins, Carolyn L, Roy, Peter J

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Compound Prioritization Methods Increase Rates of Chemical Probe Discovery in Model Organisms by Wallace, Iain M., Urbanus, Malene L., Luciani, Genna M., Burns, Andrew R., Han, Mitchell K.L., Wang, Hao, Arora, Kriti, Heisler, Lawrence E., Proctor, Michael, St. Onge, Robert P., Roemer, Terry, Roy, Peter J., Cummins, Carolyn L., Bader, Gary D., Nislow, Corey, Giaever, Guri

“…Preselection of compounds that are more likely to induce a phenotype can increase the efficiency and reduce the costs for model organism screening. To identify…”
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Evaluation of iterative alignment algorithms for multiple alignment by Wallace, Iain M., Orla, O'Sullivan, Higgins, Desmond G.

“…Motivation: Iteration has been used a number of times as an optimization method to produce multiple alignments, either alone or in combination with other…”
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phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis by Alfred, Simon E, Surendra, Anuradha, Le, Chris, Lin, Ken, Mok, Alexander, Wallace, Iain M, Proctor, Michael, Urbanus, Malene L, Giaever, Guri, Nislow, Corey

“…Chemical biology, the interfacial discipline of using small molecules as probes to investigate biology, is a powerful approach of developing specific, rapidly…”
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Fast embedding methods for clustering tens of thousands of sequences by Blackshields, Gordon, Larkin, Mark, Wallace, Iain M., Wilm, Andreas, Higgins, Desmond G.

“…Most sequence clustering methods require a full distance matrix to be computed between all pairs of sequences. This requires computer memory and time…”
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