Search Results - "Wallace, Chris"

A more accurate method for colocalisation analysis allowing for multiple causal variants by Wallace, Chris

“…In genome-wide association studies (GWAS) it is now common to search for, and find, multiple causal variants located in close proximity. It has also become…”
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Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses by Wallace, Chris

“…Horizontal integration of summary statistics from different GWAS traits can be used to evaluate evidence for their shared genetic causality. One popular method…”
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Statistical Testing of Shared Genetic Control for Potentially Related Traits by Wallace, Chris

“…ABSTRACT Integration of data from genome‐wide single nucleotide polymorphism (SNP) association studies of different traits should allow researchers to…”
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Accurate detection of shared genetic architecture from GWAS summary statistics in the small-sample context by Willis, Thomas W, Wallace, Chris

“…Assessment of the genetic similarity between two phenotypes can provide insight into a common genetic aetiology and inform the use of pleiotropy-informed,…”
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Bayesian test for colocalisation between pairs of genetic association studies using summary statistics by Giambartolomei, Claudia, Vukcevic, Damjan, Schadt, Eric E, Franke, Lude, Hingorani, Aroon D, Wallace, Chris, Plagnol, Vincent

“…Genetic association studies, in particular the genome-wide association study (GWAS) design, have provided a wealth of novel insights into the aetiology of a…”
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A pleiotropy-informed Bayesian false discovery rate adapted to a shared control design finds new disease associations from GWAS summary statistics by Liley, James, Wallace, Chris

“…Genome-wide association studies (GWAS) have been successful in identifying single nucleotide polymorphisms (SNPs) associated with many traits and diseases…”
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Improving the coverage of credible sets in Bayesian genetic fine-mapping by Hutchinson, Anna, Watson, Hope, Wallace, Chris

“…Genome Wide Association Studies (GWAS) have successfully identified thousands of loci associated with human diseases. Bayesian genetic fine-mapping studies aim…”
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fcfdr: an R package to leverage continuous and binary functional genomic data in GWAS by Hutchinson, Anna, Liley, James, Wallace, Chris

“…Genome-wide association studies (GWAS) are limited in power to detect associations that exceed the stringent genome-wide significance threshold. This…”
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Consensus clustering for Bayesian mixture models by Coleman, Stephen, Kirk, Paul D W, Wallace, Chris

“…Cluster analysis is an integral part of precision medicine and systems biology, used to define groups of patients or biomolecules. Consensus clustering is an…”
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Widespread seasonal gene expression reveals annual differences in human immunity and physiology by Dopico, Xaquin Castro, Evangelou, Marina, Ferreira, Ricardo C., Guo, Hui, Pekalski, Marcin L., Smyth, Deborah J., Cooper, Nicholas, Burren, Oliver S., Fulford, Anthony J., Hennig, Branwen J., Prentice, Andrew M., Ziegler, Anette-G., Bonifacio, Ezio, Wallace, Chris, Todd, John A.

“…Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display…”
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The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery by Adams, David, Altucci, Lucia, Amit, Ido, Aparicio, Samuel, Arima, Takahiro, Asnafi, Vahid, Bae, Jae-Bum, Bassler, Kevin, Bilenky, Mikhail, Boehm, Bernhard, Bourque, Guillaume, Brors, Benedikt, Bussemakers, Marion J., Chadwick, Lisa, Chen, Wei, Cheung, Tom H., Choi, Nak Hyen, Chung, Ho-Ryun, Clarke, Laura, Dermitzakis, Manolis, Dylag, Tomasz, Eaves, Connie J., Ebert, Peter, Eils, Jürgen, Enver, Tariq, Ferguson-Smith, Anne, Fitzgibbon, Jude, Flicek, Paul, Fraser, Peter, Gasparoni, Nina, Gasparoni, Gilles, Heath, Simon, Helin, Kristian, Hitz, Benjamin C., Horsthemke, Bernhard, Ip, Nancy Y., Ito, Takashi, Jenuwein, Thomas, Joly, Yann, Kanai, Yae, Kang, Hee Gyung, Kiemer, Alexandra K., Kim, Song Cheol, Kim, Bong-Jo, Lehrach, Hans, Leitão, Elsa, Lengauer, Thomas, Lernmark, Åke, Leung, Gilberto K.K., Leung, Danny, Ma, Yussanne, Martin-Subero, Jose Ignacio, Maschke, Karen, Merten, Christoph, Minucci, Saverio, Mitsuyama, Totai, Moore, Richard A., Nordström, Karl, Norstedt, Irene, Ouellette, Francis, Pap, Thomas, Pelicci, Pier Giuseppe, Phillips, Anthony G., Polansky, Julia, Pospisilik, J. Andrew, Prabhakar, Shyam, Procaccini, Dena C., Radbruch, Andreas, Rajewsky, Nikolaus, Rakyan, Vardham, Richardson, David, Rothstein, Mark, Sasaki, Hiroyuki, Sauer, Sascha, Schmidt, Florian, Schultze, Joachim L., Schulyer, Ronald P., Schulz, Marcel, Siebert, Reiner, Sinha, Anupam, Soranzo, Nicole, Spivakov, Mikhail, Steidl, Christian, Suzuki, Narumi, Torrents, David, Tyson, Frederick L., Ullrich, Sebastian, Ushijima, Toshikazu, Valencia, Alfonso, Wallace, Chris, Weber, Stephanie, Weiler, Nina, Weng, Andrew, Wilder, Steven, Yamashita, Yasuhiro, Yap, Desmond Y., Yip, Kevin Y., Yip, Stephen, Zerbino, Daniel, Zipprich, Gideon

“…The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell…”
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Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR by Hutchinson, Anna, Reales, Guillermo, Willis, Thomas, Wallace, Chris

“…Genome-wide association studies (GWAS) have identified thousands of genetic variants that are associated with complex traits. However, a stringent significance…”
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Sharing GWAS summary statistics results in more citations by Reales, Guillermo, Wallace, Chris

“…Rates of sharing of genome-wide association studies (GWAS) summary statistics are historically low, limiting potential for scientific discovery. Here we show,…”
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Central bank communication design in a Lucas-Phelps economy by Myatt, David P., Wallace, Chris

“…In a Lucas-Phelps island economy, an island has access to many informative signals about demand conditions. Each signal incorporates both public and private…”
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Early versus persistent Complex Regional Pain Syndrome: Is there a difference in patient reported outcomes following rehabilitation? by Lewis, Jennifer S., Wallace, Chris S., White, Paul, Mottram, Laura, Ockenden, Gareth, Rehm, Kjetil, Walker, Kate

“…Background Expert consensus asserts that early treatment of Complex Regional Pain Syndrome (CRPS) leads to better outcomes. Yet no evidence supports this…”
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CoPheScan: phenome-wide association studies accounting for linkage disequilibrium by Manipur, Ichcha, Reales, Guillermo, Sul, Jae Hoon, Shin, Myung Kyun, Longerich, Simonne, Cortes, Adrian, Wallace, Chris

“…Phenome-wide association studies (PheWAS) facilitate the discovery of associations between a single genetic variant with multiple phenotypes. For variants…”
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Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls by Fortune, Mary D, Guo, Hui, Burren, Oliver, Schofield, Ellen, Walker, Neil M, Ban, Maria, Sawcer, Stephen J, Bowes, John, Worthington, Jane, Barton, Anne, Eyre, Steve, Todd, John A, Wallace, Chris

“…Mary Fortune, Chris Wallace and colleagues report a new method that allows statistical colocalization of genetic risk variants for related autoimmune diseases…”
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A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes by FERREIRA, Ricardo C, HUI GUO, LYONS, Paul A, SMITH, Kenneth G. C, ACHENBACH, Peter, BEYERLEIN, Andreas, DUNGER, David B, CLAYTON, David G, WICKER, Linda S, TODD, John A, BONIFACIO, Ezio, WALLACE, Chris, COULSON, Richard M. R, ZIEGLER, Anette-G, SMYTH, Deborah J, PEKALSKI, Marcin L, BURREN, Oliver S, CUTLER, Antony J, DOECKE, James D, FLINT, Shaun, MCKINNEY, Eoin F

“…Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by the appearance of circulating autoantibodies to pancreatic islets. However, almost…”
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Vascularized Groin Lymph Node Transfer Using the Wrist as a Recipient Site for Management of Postmastectomy Upper Extremity Lymphedema by Lin, Cheng-Hung, Ali, Rozina, Chen, Shin-Cheh, Wallace, Chris, Chang, Yu-Chen, Chen, Hung-Chi, Cheng, Ming-Huei

“…Restoring the continuity of lymphatic drainage by lymphaticovenous or lymphaticolymphatic anastomosis was observed in the short term to be patent but…”
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Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases by Asimit, Jennifer L., Rainbow, Daniel B., Fortune, Mary D., Grinberg, Nastasiya F., Wicker, Linda S., Wallace, Chris

“…Thousands of genetic variants are associated with human disease risk, but linkage disequilibrium (LD) hinders fine-mapping the causal variants. Both lack of…”
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