Search Results - "Wallace, A V"

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide by Sebzda, Eric, Wallace, Valerie A., Mayer, John, Rae S. M. Yeung, Mak, Tak W., Ohashi, Pamela S.

“…T lymphocyte maturation is dependent on interactions between the T cell receptor (TCR) expressed on the developing thymocyte and intrathymic major…”
Get full text

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum by Wallace, Valerie A.

“…Purkinje cells (PCs) are the projection neurons of the cerebellar cortex. They receive two major types of synaptic input – that from the inferior olive via…”
Get full text

ϒ-secretase and LARG mediate distinct RGMa activities to control appropriate layer targeting within the optic tectum by Banerjee, P, Harada, H, Tassew, N G, Charish, J, Goldschneider, D, Wallace, V A, Sugita, S, Mehlen, P, Monnier, P P

“…While a great deal of progress has been made in understanding the molecular mechanisms that regulate retino-tectal mapping, the determinants that target…”
Get full text

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice by Kishihara, K, Penninger, J, Wallace, V A, Kündig, T M, Kawai, K, Wakeham, A, Timms, E, Pfeffer, K, Ohashi, P S, Thomas, M L

“…The transmembrane tyrosine phosphatase CD45 is expressed in multiple isoforms on all nucleated hematopoietic cells, resulting from alternative splicing of…”
Get more information

IBMX, Taurine and 9-cis Retinoic Acid all Act to Accelerate Rhodopsin Expression in Postmitotic Cells by WALLACE, VALERIE A, JENSEN, ABBIE M

“…Birth dating studies in the rodent retina have shown that rod photoreceptors are generated throughout most of retinal development, yet the majority do not…”
Get full text

A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice by Wallace, V A, Kondo, S, Kono, T, Xing, Z, Timms, E, Furlonger, C, Keystone, E, Gauldie, J, Sauder, D N, Mak, T W

“…The tight skin (Tsk/+) mouse represents a murine model of heritable fibrosis with some similarities to the skin fibrosis seen in human scleroderma. Tsk/+…”
Get more information

A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve by Wallace, V A, Raff, M C

“…Retinal ganglion cell (RGC) axons have been shown to stimulate the proliferation of astrocytes in the developing rodent optic nerve, but the signals that…”
Get full text

Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development by Dakubo, Gabriel D, Wang, Ya Ping, Mazerolle, Chantal, Campsall, Katrina, McMahon, Andrew P, Wallace, Valerie A

“…The development of optic stalk neuroepithelial cells depends on Hedgehog (Hh) signaling, yet the source(s) of Hh protein in the optic stalk is unknown. We…”
Get full text

Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina by Jensen, A M, Wallace, V A

“…We show that Sonic hedgehog and patched are expressed in adjacent domains in the developing mouse retina. Treatment of cultures of perinatal mouse retinal…”
Get full text

Novel cobalt complex inhibitors of mitochondrial calcium uptake by UNITT, J. F, BODEN, K. L, WALLACE, A. V, INGALL, A. H, COOMBS, M. E, INCE, F

“…Reperfusion of the ischaemic myocardium leads to intracellular calcium overload followed by mitochondrial dysfunction, resulting in insufficient energy supply…”
Get full text

Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells by Wallace, Valerie A, Wang, Ya Ping, Dakubo, Gabriel, Howley, Paul, Campsall, Katrina D, Mazarolle, Chantal J, Shiga, Sarah A, Lewis, Paula M, McMahon, Andrew P

“…The adult retina is organized into three cellular layers-an outer photoreceptor, a middle interneuron and an inner retinal ganglion cell (RGC) layer. Although…”
Get full text

Induction of experimental autoimmune myocarditis in mice lacking CD3 or CD8 molecules by PENNINGER, J. M, NEU, N, TIMMS, E, WALLACE, V. A, DOW-RHOON KOH, KISHIRA, K, PUMMERER, C, MAK, T. W

“…Experimental induction of most autoimmune diseases appears to depend on the activation of CD4 super(+) T helper cells, while CD8 super(+) lymphocytes may have…”
Get full text

Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development by Ferguson, Kerry L., Vanderluit, Jacqueline L., Hébert, Jean M., McIntosh, W.C., Tibbo, Emma, MacLaurin, Jason G., Park, David S., Wallace, Valerie A., Vooijs, Marc, McConnell, Susan K., Slack, Ruth S.

“…Correct cell cycle regulation and terminal mitosis are critical for nervous system development. The retinoblastoma (Rb) protein is a key regulator of these…”
Get full text

Extracellular calcium modulates insulin's action on enzymes controlling cyclic AMP metabolism in intact hepatocytes by IRVINE, F, WALLACE, A. V, SARAWAK, S. R, HOUSLAY, M. D

“…Absence of physiological concentrations of extracellular Ca2+ in the Krebs-Henseleit incubation buffer did not affect the ability of 10 nM glucagon (< 5%) to…”
Get full text

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny by Fung-Leung, W P, Wallace, V A, Gray, D, Sha, W C, Pircher, H, Teh, H S, Loh, D Y, Mak, T W

“…During thymic development, immature thymocytes expressing major histocompatibility complex (MHC) class I-restricted T cell receptors (TcR) differentiate into…”
Get more information

Involvement of both T cell receptor V alpha and V beta variable region domains and alpha chain junctional region in viral antigen recognition by Brändle, D, Bürki, K, Wallace, V A, Rohrer, U H, Mak, T W, Malissen, B, Hengartner, H, Pircher, H

“…We have studied the lymphocytic choriomeningitis virus (LCMV)-specific cytotoxic T cell response in transgenic mice expressing either the T cell receptor (TcR)…”
Get more information

Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes by Heyworth, C M, Wallace, A V, Houslay, M D

“…Glucagon (10 nM) caused a transient elevation of intracellular cyclic AMP concentrations, which reached a peak in around 5 min, and slowly returned to basal…”
Get full text

Antianxiety properties of the angiotensin II antagonist, DUP 753, in the rat using the elevated plus-maze by Kaiser, F C, Palmer, G C, Wallace, A V, Carr, R D, Fraser-Rae, L, Hallam, C

“…The angiotensin II receptor antagonist, DUP 753 (Losartan), was compared with diazepam for antianxiety properties in the rat using the elevated plus-maze. Oral…”
Get more information

Hedgehogs and retinal ganglion cells: organizers of the mammalian retina by Dakubo, Gabriel D, Wallace, Valerie A

“…The mature vertebrate retina develops from a population of multipotential neural progenitor cells that give rise to all of the retinal neurons and one glial…”
Get full text

Abnormalities of the vitreoretinal interface caused by dysregulated Hedgehog signaling during retinal development by Black, Graeme C.M., Mazerolle, Chantal J., Wang, Yaping, Campsall, Katrina D., Petrin, Dino, Leonard, Brian C., Damji, Karim F., Evans, D. Gareth, McLeod, David, Wallace, Valerie A.

“…Mutations in Patched (PTCH), encoding the Hedgehog (Hh) receptor, underlie Basal Cell Naevus syndrome (BCNS) and, in addition to tumor predisposition, are…”
Get full text