Search Results - "Wall, Jeffrey D"

Function and regulation of AUTS2, a gene implicated in autism and human evolution by Oksenberg, Nir, Stevison, Laurie, Wall, Jeffrey D, Ahituv, Nadav

“…Nucleotide changes in the AUTS2 locus, some of which affect only noncoding regions, are associated with autism and other neurological disorders, including…”
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Inferring Human Demographic Histories of Non-African Populations from Patterns of Allele Sharing by Wall, Jeffrey D.

“…Recent human-genetics studies have come to different conclusions regarding how and when modern humans spread out of Africa and into the rest of the world. I…”
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Fast and flexible simulation of DNA sequence data by Chen, Gary K, Marjoram, Paul, Wall, Jeffrey D

“…Simulation of genomic sequences under the coalescent with recombination has conventionally been impractical for regions beyond tens of megabases. This work…”
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A comparison of humans and baboons suggests germline mutation rates do not track cell divisions by Wu, Felix L, Strand, Alva I, Cox, Laura A, Ober, Carole, Wall, Jeffrey D, Moorjani, Priya, Przeworski, Molly

“…In humans, most germline mutations are inherited from the father. This observation has been widely interpreted as reflecting the replication errors that accrue…”
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Genomic structure in Europeans dating back at least 36,200 years by Seguin-Orlando, Andaine, Korneliussen, Thorfinn S., Sikora, Martin, Malaspinas, Anna-Sapfo, Manica, Andrea, Moltke, Ida, Albrechtsen, Anders, Ko, Amy, Margaryan, Ashot, Moiseyev, Vyacheslav, Goebel, Ted, Westaway, Michael, Lambert, David, Khartanovich, Valeri, Wall, Jeffrey D., Nigst, Philip R., Foley, Robert A., Lahr, Marta Mirazon, Nielsen, Rasmus, Orlando, Ludovic, Willerslev, Eske

“…The origin of contemporary Europeans remains contentious. We obtained a genome sequence from Kostenki 14 in European Russia dating from 38,700 to 36,200 years…”
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Possible ancestral structure in human populations by Plagnol, Vincent, Wall, Jeffrey D

“…Determining the evolutionary relationships between fossil hominid groups such as Neanderthals and modern humans has been a question of enduring interest in…”
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Genetic evidence for archaic admixture in Africa by Hammer, Michael F, Woerner, August E, Mendez, Fernando L, Watkins, Joseph C, Wall, Jeffrey D

“…A long-debated question concerns the fate of archaic forms of the genus HOMO: did they go extinct without interbreeding with anatomically modern humans, or are…”
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Higher levels of neanderthal ancestry in East Asians than in Europeans by Wall, Jeffrey D, Yang, Melinda A, Jay, Flora, Kim, Sung K, Durand, Eric Y, Stevison, Laurie S, Gignoux, Christopher, Woerner, August, Hammer, Michael F, Slatkin, Montgomery

“…Neanderthals were a group of archaic hominins that occupied most of Europe and parts of Western Asia from ∼30,000 to 300,000 years ago (KYA). They coexisted…”
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Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees by Leffler, Ellen M., Gao, Ziyue, Pfeifer, Susanne, Ségurel, Laure, Auton, Adam, Venn, Oliver, Bowden, Rory, Bontrop, Ronald, Wall, Jeffrey D., Sella, Guy, Donnelly, Peter, McVean, Gilean, Przeworski, Molly

“…Instances in which natural selection maintains genetic variation in a population over millions of years are thought to be extremely rare. We conducted a…”
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Estimating genotype error rates from high-coverage next-generation sequence data by Wall, Jeffrey D, Tang, Ling Fung, Zerbe, Brandon, Kvale, Mark N, Kwok, Pui-Yan, Schaefer, Catherine, Risch, Neil

“…Exome and whole-genome sequencing studies are becoming increasingly common, but little is known about the accuracy of the genotype calls made by the commonly…”
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Evaluating the quality of the 1000 genomes project data by Belsare, Saurabh, Levy-Sakin, Michal, Mostovoy, Yulia, Durinck, Steffen, Chaudhuri, Subhra, Xiao, Ming, Peterson, Andrew S, Kwok, Pui-Yan, Seshagiri, Somasekar, Wall, Jeffrey D

“…Data from the 1000 Genomes project is quite often used as a reference for human genomic analysis. However, its accuracy needs to be assessed to understand the…”
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A worldwide survey of haplotype variation and linkage disequilibrium in the human genome by Rosenberg, Noah A, Conrad, Donald F, Jakobsson, Mattias, Coop, Graham, Wen, Xiaoquan, Wall, Jeffrey D, Pritchard, Jonathan K

“…Recent genomic surveys have produced high-resolution haplotype information, but only in a small number of human populations. We report haplotype structure…”
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Efficient Genome-Wide Sequencing and Low-Coverage Pedigree Analysis from Noninvasively Collected Samples by Snyder-Mackler, Noah, Majoros, William H, Yuan, Michael L, Shaver, Amanda O, Gordon, Jacob B, Kopp, Gisela H, Schlebusch, Stephen A, Wall, Jeffrey D, Alberts, Susan C, Mukherjee, Sayan, Zhou, Xiang, Tung, Jenny

“…Research on the genetics of natural populations was revolutionized in the 1990s by methods for genotyping noninvasively collected samples. However, these…”
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Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese by Wei, Chun-Yu, Yang, Jenn-Hwai, Yeh, Erh-Chan, Tsai, Ming-Fang, Kao, Hsiao-Jung, Lo, Chen-Zen, Chang, Lung-Pao, Lin, Wan-Jia, Hsieh, Feng-Jen, Belsare, Saurabh, Bhaskar, Anand, Su, Ming-Wei, Lee, Te-Chang, Lin, Yi-Ling, Liu, Fu-Tong, Shen, Chen-Yang, Li, Ling-Hui, Chen, Chien-Hsiun, Wall, Jeffrey D., Wu, Jer-Yuarn, Kwok, Pui-Yan

“…Personalized medical care focuses on prediction of disease risk and response to medications. To build the risk models, access to both large-scale genomic…”
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Sex-biased evolutionary forces shape genomic patterns of human diversity by Hammer, Michael F, Mendez, Fernando L, Cox, Murray P, Woerner, August E, Wall, Jeffrey D

“…Comparisons of levels of variability on the autosomes and X chromosome can be used to test hypotheses about factors influencing patterns of genomic variation…”
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Inconsistencies in Neanderthal genomic DNA sequences by Wall, Jeffrey D, Kim, Sung K

“…Two recently published papers describe nuclear DNA sequences that were obtained from the same Neanderthal fossil. Our reanalyses of the data from these studies…”
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The pattern of polymorphism in Arabidopsis thaliana by Nordborg, Magnus, Hu, Tina T, Ishino, Yoko, Jhaveri, Jinal, Toomajian, Christopher, Zheng, Honggang, Bakker, Erica, Calabrese, Peter, Gladstone, Jean, Goyal, Rana, Jakobsson, Mattias, Kim, Sung, Morozov, Yuri, Padhukasahasram, Badri, Plagnol, Vincent, Rosenberg, Noah A, Shah, Chitiksha, Wall, Jeffrey D, Wang, Jue, Zhao, Keyan, Kalbfleisch, Theodore, Schulz, Vincent, Kreitman, Martin, Bergelson, Joy

“…We resequenced 876 short fragments in a sample of 96 individuals of Arabidopsis thaliana that included stock center accessions as well as a hierarchical sample…”
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Proposing the core contributor withdrawal theory (CCWT) to understand core contributor withdrawal from online peer-production communities by Jiang, Ling, Mirkovski, Kristijan, D. Wall, Jeffrey, Wagner, Christian, Benjamin Lowry, Paul

“…Purpose Drawing on sensemaking and emotion regulation research, the purpose of this paper is to reconceptualize core contributor withdrawal (CCW) in the…”
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Polygenic risk score portability for common diseases across genetically diverse populations by Moreno-Grau, Sonia, Vernekar, Manvi, Lopez-Pineda, Arturo, Mas-Montserrat, Daniel, Barrabés, Míriam, Quinto-Cortés, Consuelo D, Moatamed, Babak, Lee, Ming Ta Michael, Yu, Zhenning, Numakura, Kensuke, Matsuda, Yuta, Wall, Jeffrey D, Ioannidis, Alexander G, Katsanis, Nicholas, Takano, Tomohiro, Bustamante, Carlos D

“…Polygenic risk scores (PRS) derived from European individuals have reduced portability across global populations, limiting their clinical implementation at…”
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Detecting Recombination Hotspots from Patterns of Linkage Disequilibrium by Wall, Jeffrey D, Stevison, Laurie S

“…With recent advances in DNA sequencing technologies, it has become increasingly easy to use whole-genome sequencing of unrelated individuals to assay patterns…”
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