Search Results - "Walker, Wendy"

The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity by Silver, Adam C., Arjona, Alvaro, Walker, Wendy E., Fikrig, Erol

“…Circadian rhythms refer to biologic processes that oscillate with a period of ∼24 hr. These rhythms are sustained by a molecular clock and provide a temporal…”
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Don't go breaking my heart: Peli1 and myocardial ischemia reperfusion injury by Walker, Wendy E

“…Peli1 plays a key role in macrophage M1 polarization, via IRF5 activation, and thereby contributes to myocardial ischemia/reperfusion injury…”
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STING and TRIF Contribute to Mouse Sepsis, Depending on Severity of the Disease Model by Heipertz, Erica L, Harper, Jourdan, Walker, Wendy E

“…ABSTRACTIFN regulatory factor (IRF)3 plays a detrimental role in the cecal ligation and puncture (CLP) mouse model of sepsis. However, it is unclear which…”
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The state of bereavement support in adult intensive care: A systematic review and narrative synthesis by Efstathiou, Nikolaos, Walker, Wendy, Metcalfe, Alison, Vanderspank-Wright, Brandi

“…Despite advances in medical science, patient death and family bereavement are commonly encountered in adult intensive care units (ICUs). This is the first…”
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Immunity's fourth dimension: approaching the circadian–immune connection by Arjona, Alvaro, Silver, Adam C, Walker, Wendy E, Fikrig, Erol

“…The circadian system ensures the generation and maintenance of self-sustained ∼24-h rhythms in physiology that are linked to internal and environmental…”
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Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism by Heipertz, Erica L, Harper, Jourdan, Lopez, Charlie A, Fikrig, Erol, Hughes, Michael E, Walker, Wendy E

“…Circadian rhythms coordinate an organism's activities and biological processes to the optimal time in the 24-h daylight cycle. We previously demonstrated that…”
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mPR-Specific Actions Influence Maintenance of the Blood–Brain Barrier (BBB) by Abou-Fadel, Johnathan, Jiang, Xiaoting, Padarti, Akhil, Goswami, Dinesh G., Smith, Mark, Grajeda, Brian, Bhalli, Muaz, Le, Alexander, Walker, Wendy E., Zhang, Jun

“…Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial microvascular sinusoids that result in increased susceptibility to…”
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Donation After Circulatory Death: A case study by Sque, Magi, Walker, Wendy M

“…INTRODUCTIONDonation after circulatory death (DCD) represents a major source of organs for the future expansion of transplantation practice. The UK has seen a…”
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Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary by Haspel, Jeffrey A, Anafi, Ron, Brown, Marishka K, Cermakian, Nicolas, Depner, Christopher, Desplats, Paula, Gelman, Andrew E, Haack, Monika, Jelic, Sanja, Kim, Brian S, Laposky, Aaron D, Lee, Yvonne C, Mongodin, Emmanuel, Prather, Aric A, Prendergast, Brian J, Reardon, Colin, Shaw, Albert C, Sengupta, Shaon, Szentirmai, Éva, Thakkar, Mahesh, Walker, Wendy E, Solt, Laura A

“…Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses -…”
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IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis by Heipertz, Erica L, Harper, Jourdan, Goswami, Dinesh G, Lopez, Charlie A, Nellikappallil, Jose, Zamora, Ruben, Vodovotz, Yoram, Walker, Wendy E

“…IFN regulatory factor 3 (IRF3) is a transcription factor that is activated by multiple pattern-recognition receptors. We demonstrated previously that IRF3…”
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Balancing hope and despair at the end of life: The contribution of organ and tissue donation by Walker, Wendy, PhD, MSc, PGDiP, BSc (Hons), DiPSiN, Sque, Magi, PhD, BSc (Hons), Dip.N.Ed

“…Abstract Purpose Concern for the grieving family can moderate the intentions of critical care staff to advocate deceased organ and tissue donation. Conversely,…”
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Evaluating the Timeliness and Specificity of CD69, CD64, and CD25 as Biomarkers of Sepsis in Mice by Goswami, Dinesh G., Garcia, Luiz F., Dodoo, Christopher, Dwivedi, Alok K., Zhou, Yun, Pappas, Dimitri, Walker, Wendy E.

“…ABSTRACTSepsis occurs when an infection induces a dysregulated immune response, and is most commonly bacterial in origin. This condition requires rapid…”
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Dual Signaling of MyD88 and TRIF Is Critical for Maximal TLR4-Induced Dendritic Cell Maturation by Shen, Hua, Tesar, Bethany M, Walker, Wendy E, Goldstein, Daniel R

“…TLR4 is a unique TLR because downstream signaling occurs via two separate pathways, as follows: MyD88 and Toll IL-1 receptor (TIR) domain-containing…”
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ELF4 is critical for induction of type I interferon and the host antiviral response by You, Fuping, Wang, Penghua, Yang, Long, Yang, Guang, Zhao, Yang O, Qian, Feng, Walker, Wendy, Sutton, Richard, Montgomery, Ruth, Lin, Rongtuan, Iwasaki, Akiko, Fikrig, Erol

“…Induction of type I interferon is a central event of antiviral immune responses. Fikrig and colleagues show that the transcription factor ELF4 is recruited by…”
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MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury by Mannam, Praveen, Shinn, Amanda S, Srivastava, Anup, Neamu, Radu F, Walker, Wendy E, Bohanon, Michael, Merkel, Jane, Kang, Min-Jong, Dela Cruz, Charles S, Ahasic, Amy M, Pisani, Margaret A, Trentalange, Mark, West, A Phillip, Shadel, Gerald S, Elias, Jack A, Lee, Patty J

“…Sepsis is a systemic inflammatory response to infection and a major cause of death worldwide. Because specific therapies to treat sepsis are limited, and…”
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Exposure to non-esterified fatty acids in vitro results in changes in the ovarian and follicular environment in cattle by Pedroza, Gabriela H., Lanzon, Lawrence F., Rabaglino, Maria B., Walker, Wendy L., Vahmani, Payam, Denicol, Anna C.

“…Negative energy balance (NEB) in the postpartum period of dairy cows is associated with reduced fertility to insemination later in lactation. We hypothesized…”
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Aging Impairs IFN Regulatory Factor 7 Up-Regulation in Plasmacytoid Dendritic Cells during TLR9 Activation by Stout-Delgado, Heather W, Yang, Xin, Walker, Wendy E, Tesar, Bethany M, Goldstein, Daniel R

“…Plasmacytoid dendritic cells (pDCs) are innate sensors that produce IFN-alpha in response to viral infections. Determining how aging alters the cellular and…”
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Primary Schools (A Dialogue) by Clinton, Bernadette, Grainger, Anna, Rego, Raquel Tola, Walker, Wendy

“…Our discussions ranged widely over not only digital learning but also the other issues that concern primary languages teachers at this moment. Although the…”
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Development of pharmacy emergency management guidelines by Wendy Walker

“…World disasters in the last decade - high cost damages and great human suffering - few pharmacy related procedures, plans and guidelines - what the Military…”
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IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model by Walker, Wendy E., Bozzi, Aaron T., Goldstein, Daniel R.

“…IRF3 is identified as a key mediator of inflammatory markers, bacteremia, and disease pathogenesis, in the cecal ligation and puncture model of sepsis. Much…”
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