Search Results - "Walker, R. B."

Cortisol-cause and cure for metabolic syndrome? by Walker, B. R.

“…Similarities between the metabolic syndrome and Cushing's syndrome, and reversibility of the features of Cushing's syndrome, suggest that cortisol may…”
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The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk by Drake, AJ, Walker, BR

“…Many epidemiological studies in diverse populations have demonstrated a link between low birth weight and subsequent disease. This evidence has given rise to…”
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Estrogens protect male mice from obesity complications and influence glucocorticoid metabolism by Dakin, R S, Walker, B R, Seckl, J R, Hadoke, P W F, Drake, A J

“…Background: Although the prevalence of obesity is higher among women than men, they are somewhat protected from the associated cardiometabolic consequences…”
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Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case–control study by Souverein, P C, Berard, A, Van Staa, T P, Cooper, C, Egberts, A C G, Leufkens, H G M, Walker, B R

“…Objective: To assess whether use of oral glucocorticoids is associated with cardiovascular and cerebrovascular morbidity. Design and setting: Nested…”
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A stability-indicating high performance liquid chromatographic (HPLC) assay for the simultaneous determination of atorvastatin and amlodipine in commercial tablets by Mohammadi, A., Rezanour, N., Ansari Dogaheh, M., Ghorbani Bidkorbeh, F., Hashem, M., Walker, R.B.

“…A simple, rapid, precise and accurate isocratic reversed-phase stability-indicating HPLC method was developed and validated for the simultaneous determination…”
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Relationship Between Final Height and Health Outcomes in Adults With Congenital Adrenal Hyperplasia: United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE) by Han, T. S, Conway, G. S, Willis, D. S, Krone, N, Rees, D. A, Stimson, R. H, Arlt, W, Walker, B. R, Ross, R. J, the United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE)

“…Context: Treatment of congenital adrenal hyperplasia (CAH) in childhood focuses on growth and development and adult final height (FH) is a measure of effective…”
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Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: Nested case-control study by BRUNNER, E. J, HEMINGWAY, H, PAPADOPOULOS, A, CHECKLEY, S, RUMLEY, A, LOWE, G. D. O, STANSFELD, S. A, MARMOT, M. G, WALKER, B. R, PAGE, M, CLARKE, P, JUNEJA, M, SHIPLEY, M. J, KUMARI, M, ANDREW, R, SECKL, J. R

“…The causes of metabolic syndrome (MS), which may be a precursor of coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and…”
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Increased prevalence of non-alcoholic fatty liver disease in European women with a history of gestational diabetes by Forbes, S, Taylor-Robinson, S. D, Patel, N, Allan, P, Walker, B. R, Johnston, D. G

“…Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) is common in type 2 diabetes but it is unknown whether NAFLD is prevalent in European women at risk…”
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Glucocorticoid treatment regimen and health outcomes in adults with congenital adrenal hyperplasia by Han, T. S., Stimson, R. H., Rees, D. A., Krone, N., Willis, D. S., Conway, G. S., Arlt, W., Walker, B. R., Ross, R. J.

“…Summary Background Adults with congenital adrenal hyperplasia (CAH) are treated with a wide variety of glucocorticoid treatment regimens. Objective, design and…”
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5α‐Reduced glucocorticoids exhibit dissociated anti‐inflammatory and metabolic effects by Yang, C, Nixon, M, Kenyon, CJ, Livingstone, DEW, Duffin, R, Rossi, AG, Walker, BR, Andrew, R

“…BACKGROUND AND PURPOSE Dissociating anti‐inflammatory efficacy from the metabolic side effects of glucocorticoids is an attractive therapeutic goal…”
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Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study by Labad, J, Price, J. F, Strachan, M. W. J, Fowkes, F. G. R, Ding, J, Deary, I. J, Lee, A. J, Frier, B. M, Seckl, J. R, Walker, B. R, Reynolds, R. M

“…Aims/hypothesis The aim of the study was to identify risk factors for depression and anxiety in a well-characterised cohort of individuals with type 2 diabetes…”
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Elevated plasma cortisol concentrations : A link between low birth weight and the insulin resistance syndrome? by PHILLIPS, D. I. W, BARKER, D. J. P, FALL, C. H. D, SECKL, J. R, WHORWOOD, C. B, WOOD, P. J, WALKER, B. R

“…Recent studies have shown that reduced fetal growth is associated with the development of the insulin resistance syndrome in adult life. The mechanisms are not…”
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Tissue-specific dysregulation of cortisol metabolism in human obesity by RASK, Eva, OLSSON, Tommy, SÖDERBERG, Stefan, ANDREW, Ruth, LIVINGSTONE, Dawn E. W, JOHNSON, Owe, WALKER, Brian R

“…Cortisol has been implicated as a pathophysiological mediator in idiopathic obesity, but circulating cortisol concentrations are not consistently elevated. The…”
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A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid by Forbes, S., Godsland, I. F., Taylor-Robinson, S. D., Bell, J. D., Thomas, E. L., Patel, N., Hamilton, G., Parker, K. H., Marshall, I., Gray, C. D., Bedford, D., Caslake, M., Walker, B. R., Johnston, D. G.

“…Aims/hypothesis We have previously reported a high prevalence of non-alcoholic fatty liver disease (NAFLD) among women with previous gestational diabetes…”
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A stability-indicating high performance liquid chromatographic assay for the determination of orlistat in capsules by Mohammadi, A., Haririan, I., Rezanour, N., Ghiasi, L., Walker, R.B.

“…A stability-indicating HPLC method was developed and validated for the quantitative determination of orlistat in capsule dosage forms. An isocratic separation…”
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Independent effects of obesity and cortisol in predicting cardiovascular risk factors in men and women by Walker, B. R., Soderberg, S., Lindahl, B., Olsson, T.

“… Walker BR, Soderberg S, Lindahl B, Olsson T (University of Edinburgh, Western General Hospital, Edinburgh, UK and the University of Umea, University…”
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Glucocorticoids and insulin resistance: old hormones, new targets by Andrews, R C, Walker, B R

“…Insulin resistance has been proposed as a mediator of the association between risk factors for cardiovascular disease in the population. The clinical syndrome…”
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After Snowden: Rethinking the Impact of Surveillance by Bauman, Zygmunt, Bigo, Didier, Esteves, Paulo, Guild, Elspeth, Jabri, Vivienne, Lyon, David, Walker, R B J

“…Current revelations about the secret US-NSA program, PRISM, have confirmed the large-scale mass surveillance of the telecommunication and electronic messages…”
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Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure by Hadoke, P W F, Lindsay, R S, Seckl, J R, Walker, B R, Kenyon, C J

“…Excessive exposure to glucocorticoids during gestation reduces birth weight and induces permanent hypertension in adulthood. The mechanisms underlying this…”
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Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women by Goedecke, J. H., Wake, D. J., Levitt, N. S., Lambert, E. V., Collins, M. R., Morton, N. M., Andrew, R., Seckl, J. R., Walker, B. R.

“…Summary Objective  Glucocorticoid hyperactivity in adipose tissue, due to up‐regulation of local glucocorticoid reactivation by 11β‐hydroxysteroid…”
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