Search Results - "Walker, Nicolas J"
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1
Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet
Published in Genome Biology (08-01-2024)“…Transcription factors bind DNA in specific sequence contexts. In addition to distinguishing one nucleobase from another, some transcription factors can…”
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Insights into imprinting from parent-of-origin phased methylomes and transcriptomes
Published in Nature genetics (01-11-2018)“…Imprinting is the preferential expression of one parental allele over the other. It is controlled primarily through differential methylation of cytosine at CpG…”
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Simultaneous sequencing of genetic and epigenetic bases in DNA
Published in Nature biotechnology (01-10-2023)“…DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology. Most DNA sequencing…”
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Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer
Published in Scientific reports (04-10-2022)“…Early detection of cancer will improve survival rates. The blood biomarker 5-hydroxymethylcytosine has been shown to discriminate cancer. In a large…”
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Journal Article