Search Results - "Walker, N. M"

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus by Fung, E Y M G, Smyth, D J, Howson, J M M, Cooper, J D, Walker, N M, Stevens, H, Wicker, L S, Todd, J A

“…As a result of genome-wide association studies in larger sample sets, there has been an increase in identifying genes that influence susceptibility to…”
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Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A by Howson, J.M.M, Walker, N.M, Clayton, D, Todd, J.A

“…Until recently, human leucocyte antigen (HLA) class II-independent associations with type 1 diabetes (T1D) in the Major Histocompatibility Complex (MHC) region…”
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The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial by Scott, RAP

“…Opposing views have been published on the importance of ultrasound screening for abdominal aortic aneurysms. The Multicentre Aneurysm Screening Study was…”
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Confirmation of novel type 1 diabetes risk loci in families by Cooper, J. D., Howson, J. M. M., Smyth, D., Walker, N. M., Stevens, H., Yang, J. H. M., She, J.-X., Eisenbarth, G. S., Rewers, M., Todd, J. A., Akolkar, B., Concannon, P., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., Nierras, C., Pociot, F., Rich, S. S.

“…Aims/hypothesis Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent…”
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No association of multiple type 2 diabetes loci with type 1 diabetes by Raj, S. M, Howson, J. M. M, Walker, N. M, Cooper, J. D, Smyth, D. J, Field, S. F, Stevens, H. E, Todd, J. A

“…Aims/hypothesis We used recently confirmed type 2 diabetes gene regions to investigate the genetic relationship between type 1 and type 2 diabetes, in an…”
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Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction by Walker, Andrew M N, Drozd, Michael, Hall, Marlous, Patel, Peysh A, Paton, Maria, Lowry, Judith, Gierula, John, Byrom, Rowenna, Kearney, Lorraine, Sapsford, Robert J, Witte, Klaus K, Kearney, Mark T, Cubbon, Richard M

“…Background Noncardiovascular death is increasingly common in people with chronic heart failure ( CHF ), yet its causes remain poorly characterized. We aimed to…”
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Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects by FIELD, S. F, HOWSON, J. M. M, SMYTH, D. J, WALKER, N. M, DUNGER, D. B, TODD, J. A

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Quantifying the risks of hypertension, age, sex and smoking in patients with abdominal aortic aneurysm by Vardulaki, K. A., Walker, N. M., Day, N. E., Duffy, S. W., Ashton, H. A., Scott, R. A. P.

“…Background: The prevalence of abdominal aortic aneurysm (AAA) in a community‐based sample of men and women aged 65–79 years was correlated with known risk…”
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Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families by Howson, J M M, Walker, N M, Smyth, D J, Todd, J A

“…In recent years the pace of discovery of genetic associations with type I diabetes (T1D) has accelerated, with the total number of confirmed loci, including…”
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Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls by Field, S. F, Howson, J. M. M, Walker, N. M, Dunger, D. B, Todd, J. A

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Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families by Cooper, J D, Walker, N M, Smyth, D J, Downes, K, Healy, B C, Todd, J A

“…The advent of genome-wide association (GWA) studies has revolutionized the detection of disease loci and provided abundant evidence for previously undetected…”
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Growth rates and risk of rupture of abdominal aortic aneurysms by Vardulaki, K. A., Prevost, T. C., Walker, N. M., Day, N. E., Wilmink, A. B. M., Quick, C. R. G., Ashton, H. A., Scott, R. A. P.

“…Background Early identification of abdominal aortic aneurysms (AAAs) may reduce the risk of death from rupture by providing the opportunity for elective…”
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Functional activity of Pat-1 (Slc26a6) Cl−/HCO3− exchange in the lower villus epithelium of murine duodenum by Walker, N. M., Simpson, J. E., Hoover, E. E., Brazill, J. M., Schweinfest, C. W., Soleimani, M., Clarke, L. L.

“…Aims:  The apical membrane anion exchanger putative anion transporter‐1 (Pat‐1) is expressed at significant levels in the lower villus epithelium of murine…”
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Late results concerning feasibility and compliance from a randomized trial of ultrasonographic screening for abdominal aortic aneurysm by Vardulaki, K. A., Walker, N. M., Couto, E., Day, N. E., Thompson, S. G., Ashton, H. A., Scott, R. A. P.

“…Background: The study was an update at 10 years of a randomized trial of the efficacy of screening for abdominal aortic aneurysm (AAA). The extent of benefit,…”
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Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction by Mercer, Ben N, Koshy, Aaron, Drozd, Michael, Walker, Andrew M N, Patel, Peysh A, Kearney, Lorraine, Gierula, John, Paton, Maria F, Lowry, Judith E, Kearney, Mark T, Cubbon, Richard M, Witte, Klaus K

“…Background The CASTLE - AF (Catheter Ablation versus Standard Conventional Therapy in Patients With Left Ventricular Dysfunction and Atrial Fibrillation) trial…”
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Distinct, common and synergistic effects of insulin and IGF-1 receptors on healthy murine ageing by Walker, Andrew MN, Watt, Nicole T., Yuldasheva, Nadira Y., Dalmia, Sanjush, Conning-Rowland, Marcella, Cheng, Chew W., Warmke, Nele, Bridge, Katherine, Brown, Oliver I., Luk, Cheukyau, Drozd, Michael, Haywood, Natalie J., Skromna, Anna, Makava, Natasha, Wheatcroft, Stephen B., Kearney, Mark T., Cubbon, Richard M.

“…Reduced IGF-1 signalling is an evolutionarily conserved mediator of longevity, yet the magnitude of this effect is substantially larger in organisms retaining…”
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Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1 by Cooper, J D, Walker, N M, Healy, B C, Smyth, D J, Downes, K, Todd, J A

“…A candidate gene study was conducted on 10 established type II diabetes genes and 45 genes associated with autoimmune diseases, including type I diabetes…”
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Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop by Viswambharan, Hema, Yuldasheva, Nadira, Sengupta, Anshuman, Imrie, Helen, Gage, Matthew, Haywood, Natalie, Walker, Andrew MN, Skromna, Anna, Makova, Natallia, Galloway, Stacey, Shah, Pooja, Sukumar, Piruthivi, Porter, Karen E, Grant, Peter J, Shah, Ajay M, Santos, Celio XC, Li, Jing, Beech, David J, Wheatcroft, Stephen B, Cubbon, Richard M, Kearney, Mark T

“…RATIONALE:In the endothelium, insulin stimulates endothelial nitric oxide synthase (eNOS) to generate the anti-atherosclerotic signalling radical NO. Insulin…”
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The Long-term Benefits of a Single Scan for Abdominal Aortic Aneurysm (AAA) at Age 65 by Scott, R.A.P., Vardulaki, K.A, Walker, N.M, Day, N.E., Duffy, S.W., Ashton, H.A.

“…Aim to investigate the efficacy of a single ultrasonic scan at age 65 to identify patients at risk from ruptured abdominal aortic aneurysm (AAA). Method a…”
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Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance by Watt, Nicole T, Gage, Matthew C, Patel, Peysh A, Viswambharan, Hema, Sukumar, Piruthivi, Galloway, Stacey, Yuldasheva, Nadira Y, Imrie, Helen, Walker, Andrew M N, Griffin, Kathryn J, Makava, Natalia, Skromna, Anna, Bridge, Katherine, Beech, David J, Schurmans, Stéphane, Wheatcroft, Stephen B, Kearney, Mark T, Cubbon, Richard M

“…Shc homology 2-containing inositol 5' phosphatase-2 (SHIP2) is a lipid phosphatase that inhibits insulin signaling downstream of phosphatidylinositol 3-kinase…”
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