Search Results - "Walker, Melanie R."

Acquisition and decay of IgM and IgG responses to merozoite antigens after Plasmodium falciparum malaria in Ghanaian children by Walker, Melanie R, Knudsen, Anne S, Partey, Frederica D, Bassi, Maria R, Frank, Asger M, Castberg, Filip C, Sarbah, Edem W, Ofori, Michael F, Hviid, Lars, Barfod, Lea

“…Developing a vaccine against Plasmodium falciparum malaria has been challenging, primarily due to high levels of antigen polymorphism and a complex parasite…”
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Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design by Keck, Zhen-Yong, Pierce, Brian G, Lau, Patrick, Lu, Janine, Wang, Yong, Underwood, Alexander, Bull, Rowena A, Prentoe, Jannick, Velázquez-Moctezuma, Rodrigo, Walker, Melanie R, Luciani, Fabio, Guest, Johnathan D, Fauvelle, Catherine, Baumert, Thomas F, Bukh, Jens, Lloyd, Andrew R, Foung, Steven K H

“…Cumulative evidence supports a role for neutralizing antibodies contributing to spontaneous viral clearance during acute hepatitis C virus (HCV) infection…”
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Enhancing neutralization of Plasmodium falciparum using a novel monoclonal antibody against the rhoptry-associated membrane antigen by Knudsen, Anne S., Walker, Melanie R., Agullet, Judit P., Björnsson, Kasper H., Bassi, Maria R., Barfod, Lea

“…The pathogenesis of malaria is associated with blood-stage infection and there is strong evidence that antibodies specific to parasite blood-stage antigens can…”
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Real-time imaging of integrin β4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing by Elaimy, Ameer L, Wang, Mengdie, Sheel, Ankur, Brown, Caitlin W, Walker, Melanie R, Amante, John J, Xue, Wen, Chan, Amanda, Baer, Christina E, Goel, Hira Lal, Mercurio, Arthur M

“…The ability to monitor changes in the expression and localization of integrins is essential for understanding their contribution to development, tissue…”
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Strain-Dependent Inhibition of Erythrocyte Invasion by Monoclonal Antibodies Against Plasmodium falciparum CyRPA by Knudsen, Anne S, Björnsson, Kasper H, Bassi, Maria R, Walker, Melanie R, Kok, Andreas, Cristinoi, Bogdan, Jensen, Anja R, Barfod, Lea

“…The highly conserved cysteine-rich protective antigen (PfCyRPA) is a key target for next-generation vaccines against blood-stage malaria. PfCyRPA constitute…”
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SARS-CoV-2 RBD-Specific Antibodies Induced Early in the Pandemic by Natural Infection and Vaccination Display Cross-Variant Binding and Inhibition by Walker, Melanie R, Podlekareva, Daria, Johnsen, Stine, Leerhøy, Bonna, Fougeroux, Cyrielle, Søgaard, Max, Salanti, Ali, Ditlev, Sisse Bolm, Barfod, Lea

“…The development of vaccine candidates for COVID-19 has been rapid, and those that are currently approved display high efficacy against the original circulating…”
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Envelope-Specific IgG3 and IgG1 Responses Are Associated with Clearance of Acute Hepatitis C Virus Infection by Walker, Melanie R, Eltahla, Auda A, Mina, Michael M, Li, Hui, Lloyd, Andrew R, Bull, Rowena A

“…Hepatitis C virus (HCV) can be cleared naturally in a subset of individuals. However, the asymptomatic nature of acute HCV infection makes the study of the…”
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Characterization of SARS‐CoV‐2 humoral immune response in a subject with unique sampling: A case report by Walker, Melanie R., Idorn, Manja, Bennett, Anja, Søgaard, Max, Salanti, Ali, Ditlev, Sisse B., Barfod, Lea

“…Background The development of vaccine candidates for COVID‐19, and the administration of booster vaccines, has meant a significant reduction in COVID‐19…”
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Understanding the Determinants of BnAb Induction in Acute HCV Infection by Underwood, Alexander P, Walker, Melanie R, Brasher, Nicholas A, Eltahla, Auda A, Maher, Lisa, Luciani, Fabio, Lloyd, Andrew R, Bull, Rowena A

“…Despite recent advances in curative therapy, hepatitis C virus (HCV) still remains a global threat. In order to achieve global elimination, a prophylactic…”
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Broadly potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineages by Walker, Melanie R., Underwood, Alexander, Björnsson, Kasper H., Raghavan, Sai Sundar Rajan, Bassi, Maria R., Binderup, Alekxander, Pham, Long V., Ramirez, Santseharay, Pinholt, Mette, Dagil, Robert, Knudsen, Anne S., Idorn, Manja, Soegaard, Max, Wang, Kaituo, Ward, Andrew B., Salanti, Ali, Bukh, Jens, Barfod, Lea

“…The continuous emergence of SARS-CoV-2 variants of concern has rendered many therapeutic monoclonal antibodies (mAbs) ineffective. To date, there are no…”
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O-linked α2,3 sialylation defines stem cell populations in breast cancer by Walker, Melanie R, Goel, Hira Lal, Mukhopadhyay, Dimpi, Chhoy, Peter, Karner, Emmet R, Clark, Jennifer L, Liu, Haibo, Li, Rui, Zhu, Julie Lihua, Chen, Shuhui, Mahal, Lara K, Bensing, Barbara A, Mercurio, Arthur M

“…We pursued the hypothesis that specific glycans can be used to distinguish breast cancer stem cells (CSCs) and influence their function. Comparison of CSCs and…”
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Differentiation of Cancer Stem Cells through Nanoparticle Surface Engineering by Geng, Yingying, Amante, John J, Goel, Hira L, Zhang, Xianzhi, Walker, Melanie R, Luther, David C, Mercurio, Arthur M, Rotello, Vincent M

“…Cancer stem cells (CSCs) are a crucial therapeutic target because of their role in resistance to chemo- and radiation therapy, metastasis, and tumor…”
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B-cell characteristics define HCV reinfection outcome by Underwood, Alexander P., Gupta, Money, Wu, Bing-Ru, Eltahla, Auda A., Boo, Irene, Wang, Jing Jing, Agapiou, David, Abayasingam, Arunasingam, Reynaldi, Arnold, Keoshkerian, Elizabeth, Zhao, Yanran, Brasher, Nicholas, Walker, Melanie R., Bukh, Jens, Maher, Lisa, Gordon, Tom, Davenport, Miles P., Luciani, Fabio, Drummer, Heidi E., Lloyd, Andrew R., Bull, Rowena A.

“…In individuals highly exposed to HCV, reinfection is common, suggesting that natural development of sterilising immunity is difficult. In those that are…”
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B cell immunodominance in primary hepatitis C virus infection by Brasher, Nicholas A., Eltahla, Auda A., Underwood, Alexander, Boo, Irene, Rizzetto, Simone, Walker, Melanie R., Rodrigo, Chaturaka, Luciani, Fabio, Maher, Lisa, Drummer, Heidi E., Tedla, Nicodemus, Lloyd, Andrew R., Bull, Rowena A.

“…Neutralising antibodies (NAbs) play a key role in clearance of HCV. NAbs have been isolated and mapped to several domains on the HCV envelope proteins…”
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Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies by Walker, Melanie R., Leung, Preston, Eltahla, Auda A., Underwood, Alexander, Abayasingam, Arunasingam, Brasher, Nicholas A., Li, Hui, Wu, Bing-Ru, Maher, Lisa, Luciani, Fabio, Lloyd, Andrew R., Bull, Rowena A.

“…Hepatitis C virus (HCV) is one of very few viruses that are either naturally cleared, or alternatively persist to cause chronic disease. Viral diversity and…”
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Alveolar progenitor cells in the mammary gland are dependent on the β4 integrin by Walker, Melanie R., Amante, John J., Li, Jiarong, Liu, Haibo, Zhu, Lihua Julie, Feltri, M. Laura, Goel, Hira Lal, Mercurio, Arthur M.

“…Understanding how progenitor cell function is regulated in the mammary gland is an important developmental problem that has significant implications for breast…”
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A method for detecting hepatitis C envelope specific memory B cells from multiple genotypes using cocktail E2 tetramers by Wu, Bing-Ru, Eltahla, Auda A., Keoshkerian, Elizabeth, Walker, Melanie R., Underwood, Alex, Brasher, Nicholas A., Agapiou, David, Lloyd, Andrew R., Bull, Rowena A.

“…Hepatitis C (HCV) is a rapidly mutating RNA virus, with a strong propensity to cause chronic infection and progressive liver disease. Recent evidence has shown…”
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Incident Hepatitis C Virus Genotype Distribution and Multiple Infection in Australian Prisons by Walker, Melanie R, Li, Hui, Teutsch, Suzy, Betz-Stablein, Brigid, Luciani, Fabio, Lloyd, Andrew R, Bull, Rowena A

“…Hepatitis C virus (HCV) is a highly diverse pathogen that is classified into seven distinct genotypes. Simultaneous or sequential reinfection with multiple HCV…”
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Anti‐envelope antibody responses in highly exposed seronegative individuals may be associated with protection from HCV infection by Mina, Michael, Underwood, Alexander, Eltahla, Auda, Wu, Bing‐Ru, Walker, Melanie R., Bull, Rowena A., Lloyd, Andrew R.

“…In rare cases, individuals with a history of long‐term injecting drug use remain seronegative and aviraemic, despite prolonged and likely repeated exposure to…”
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Limited naturally occurring escape in broadly neutralizing antibody epitopes in hepatitis C glycoprotein E2 and constrained sequence usage in acute infection by Rodrigo, Chaturaka, Walker, Melanie R., Leung, Preston, Eltahla, Auda A., Grebely, Jason, Dore, Gregory J., Applegate, Tanya, Page, Kimberly, Dwivedi, Sunita, Bruneau, Julie, Morris, Meghan D., Cox, Andrea L., Osburn, William, Kim, Arthur Y., Schinkel, Janke, Shoukry, Naglaa H., Lauer, Georg M., Maher, Lisa, Hellard, Margaret, Prins, Maria, Luciani, Fabio, Lloyd, Andrew R., Bull, Rowena A.

“…Broadly neutralizing antibodies have been associated with spontaneous clearance of the hepatitis C infection as well as viral persistence by immune escape…”
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