Search Results - "Walker, Mary W."

Anxiolytic- and Antidepressant-like Profiles of the Galanin-3 Receptor ($Gal_3$) Antagonists SNAP 37889 and SNAP 398299 by Chad J. Swanson, Thomas P. Blackburn, Xuexiang Zhang, Zheng, Kang, Xu, Zhi-Qing David, Hökfelt, Tomas, Toni D. Wolinsky, Michael J. Konkel, Heidi Chen, Huailing Zhong, Mary W. Walker, Craig, Douglas A., Christophe P. G. Gerald, Branchek, Theresa A.

“…The neuropeptide galanin mediates its effects through the receptor subtypes$Gal_1$,$Gal_2$, and$Gal_3$and has been implicated in anxiety-and depression-related…”
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Galanin receptor subtypes by Branchek, Theresa A, Smith, Kelli E, Gerald, Christophe, Walker, Mary W

“…The neuropeptide galanin, which is widely expressed in brain and peripheral tissues, exerts a broad range of physiological effects. Pharmacological studies…”
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Discovery of Lu AA33810: A highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder by Packiarajan, Mathivanan, Marzabadi, Mohammad R., Desai, Mahesh, Lu, Yalei, Noble, Stewart A., Wong, Wai C., Jubian, Vrej, Chandrasena, Gamini, Wolinsky, Toni D., Zhong, Hualing, Walker, Mary W., Wiborg, Ove, Andersen, Kim

“…The structure–activity relationship of a series of tricyclic-sulfonamide compounds 11–32 culminating in the discovery of…”
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5-(2′-Pyridyl)-2-aminothiazoles: Alkyl amino sulfonamides and sulfamides as potent NPY₅ antagonists by Packiarajan, Mathivanan, Coate, Heather, Desai, Mahesh, Jimenez, Hermogenes N, Reinhard, Emily J, Jubian, Vrej J, Marzabadi, Mohammad R, Chandrasena, Gamini, Wolinski, Toni C, Walker, Mary W, Andersen, Kim

“…Synthesis, SAR and physico-chemical properties of an alkyl aminothiazole series 8 and 16 are described. 2-Pyridylaminothiazole based compounds such as 8c and…”
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receptor subtype involved in neuropeptide-Y-induced food intake by Gerald, C, Walker, M.W, Criscione, L, Gustafson, E.L, Batzl-Hartmann, C, Smith, K.E, Vaysse, P, Durkin, M.M, Laz, T.M, Linemeyer, D.L

“…Neuropeptide (NPY) is a powerful stimulant of food intake and is proposed to activate a hypothalamic 'feeding' receptor distinct from previously cloned Y-type…”
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3-Arylimino-2-indolones Are Potent and Selective Galanin GAL3 Receptor Antagonists by Konkel, Michael J, Lagu, Bharat, Boteju, Lakmal W, Jimenez, Hermogenes, Noble, Stewart, Walker, Mary W, Chandrasena, Gamini, Blackburn, Thomas P, Nikam, Sham S, Wright, Jon L, Kornberg, Brian E, Gregory, Tracy, Pugsley, Thomas A, Akunne, Hyacinth, Zoski, Kim, Wise, Lawrence D

“…A series of 3-imino-2-indolones are the first published, high-affinity antagonists of the galanin GAL3 receptor. One example,…”
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N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists by Wu, Lingyun, Lu, Kai, Desai, Mahesh, Packiarajan, Mathivanan, Joshi, Amita, Marzabadi, Mohammad R., Jubian, Vrej, Andersen, Kim, Chandrasena, Gamini, Boyle, Noel J., Walker, Mary W.

“…Subtype specific ligands are needed to evaluate the therapeutic potential of modulating the brain’s neuropeptide Y system. The benzothiazepine glycinamide 1a…”
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Cloning and Functional Expression of a Human Y4 Subtype Receptor for Pancreatic Polypeptide, Neuropeptide Y, and Peptide YY () by Bard, Jonathan A., Walker, Mary W., Branchek, Theresa A., Weinshank, Richard L.

“…The pancreatic polypeptide family includes pancreatic polypeptide (PP), neuropeptide Y (NPY), and peptide YY (PYY). Members of the PP family regulate numerous…”
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Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system by Gustafson, Eric L, Smith, Kelli E, Durkin, Margaret M, Walker, Mary W, Gerald, Christophe, Weinshank, Richard, Branchek, Theresa A

“…Our group has recently reported the expression cloning of the human neuropeptide Y Y2 receptor DNA and subsequently the cloning of the rat homologue. These…”
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Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility by KONKEL, Michael J, PACKIARAJAN, Mathivanan, HEIDI CHEN, TOPIWALA, Upendra P, JIMENEZ, Hermogenes, TALISMAN, Ian Jamie, COATE, Heather, WALKER, Mary W

“…A series of amino analogs of 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one (1) were synthesized to improve aqueous solubility, while…”
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Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers by Estes, Anne-Marie, McAllen, Kathleen, Parker, Michael S., Sah, Renu, Sweatman, Trevor, Park, Edwards A., Balasubramaniam, Ambikaipakan, Sallee, Floyd R., Walker, Mary W., Parker, Steven L.

“…Treatment of CHO cells expressing human Y receptors (Y 1 , Y 2 or Y4 subtype) with pertussis toxin results in a large decrease in functional receptors, with a…”
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Expression Cloning and Pharmacological Characterization of a Human Hippocampal Neuropeptide Y/Peptide YY Y2 Receptor Subtype () by Gerald, Christophe, Walker, Mary W., Vaysse, Pierre J.-J., He, Chaogang, Branchek, Theresa A., Weinshank, Richard L.

“…The pancreatic polypeptide family includes neuropeptide Y (NPY), one of the most abundant neuropeptides in the mammalian nervous system, as well as peptide YY…”
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Molecular Biology and Pharmacology of Galanin Receptors by BRANCHEK, THERESA, SMITH, KELLI E., WALKER, MARY W.

“…: Galanin was first isolated 15 years ago. Diversity of galanin receptors has been suspected from the study of native tissues and functional responses to…”
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Expression Cloning of a Rat Hypothalamic Galanin Receptor Coupled to Phosphoinositide Turnover by Smith, Kelli E., Forray, Carlos, Walker, Mary W., Jones, Kenneth A., Tamm, Joseph A., Bard, Jonathan, Branchek, Theresa A., Linemeyer, David L., Gerald, Christophe

“…The neuropeptide galanin is widely distributed throughout the central and peripheral nervous systems and participates in the regulation of processes such as…”
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The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity by Walker, Mary W, Wolinsky, Toni D, Jubian, Vrej, Chandrasena, Gamini, Zhong, Huailing, Huang, Xinyan, Miller, Silke, Hegde, Laxminarayan G, Marsteller, Douglas A, Marzabadi, Mohammad R, Papp, Mariusz, Overstreet, David H, Gerald, Christophe P G, Craig, Douglas A

“…Neuropeptide Y (NPY) regulates physiological processes via receptor subtypes (Y(1), Y(2), Y(4), Y(5), and y(6)). The Y(5) receptor is well known for its role…”
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Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists by Wu, Lingyun, Lu, Kai, Packiarajan, Mathivanan, Jubian, Vrej, Chandrasena, Gamini, Wolinsky, Toni C., Walker, Mary W.

“…A novel series of indolyl and dihydroindolyl glycinamides were identified as potent NPY5 antagonists with in vivo activity from screen hit 1. The…”
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High-throughput synthesis optimization of sulfonamide NPY Y5 antagonists by Finn, John, Pelham, David, Walker, Mary W., Gluchowski, Charles

“…A series of sulfonamide neuropeptide Y Y5 antagonists was optimized by preparation of sets of analogues using high-throughput synthesis and purification…”
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Expression of a Novel Neuropeptide Y Receptor Subtype Involved in Food Intake: An in Situ Hybridization Study of Y5 mRNA Distribution in Rat Brain by Durkin, Margaret M., Walker, Mary W., Smith, Kelli E., Gustafson, Eric L., Gerald, Christophe, Branchek, Theresa A.

“…Our group has reported on the cloning of a novel rat neuropeptide Y (NPY) receptor involved in NPY-induced food intake, the Y5 receptor. The distribution in…”
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Discovery of potent and selective small molecule NPY Y5 receptor antagonists by Islam, Imadul, Dhanoa, Dale, Finn, John, Du, Ping, Walker, Mary W, Salon, John A, Zhang, Jack, Gluchowski, Charles

“…The discovery of a new class of sulfonamide NPY Y5 receptor antagonists is described. Optimization of this series led to the identification of compounds with…”
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Molecular biology and pharmacology of multiple NPY Y5 receptor species homologs by Borowsky, B, Walker, M W, Bard, J, Weinshank, R L, Laz, T M, Vaysse, P, Branchek, T A, Gerald, C

“…NPY is a 36-amino acid peptide which exerts its physiological effects through the activation of a family of G-protein coupled receptors. In vivo and in vitro…”
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