Search Results - "Walker, Keith A."

Novel Series of Dihydropyridinone P2X7 Receptor Antagonists by Lopez-Tapia, Francisco, Walker, Keith A. M, Brotherton-Pleiss, Christine, Caroon, Joanie, Nitzan, Dov, Lowrie, Lee, Gleason, Shelley, Zhao, Shu-Hai, Berger, Jacob, Cockayne, Debra, Phippard, Deborah, Suttmann, Rebecca, Fitch, William L, Bourdet, David, Rege, Pankaj, Huang, Xiaojun, Broadbent, Scott, Dvorak, Charles, Zhu, Jiang, Wagner, Paul, Padilla, Fernando, Loe, Brad, Jahangir, Alam, Alker, André

“…Identification of singleton P2X7 inhibitor 1 from HTS gave a pharmacophore that eventually turned into potential clinical candidates 17 and 19. During…”
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Oligonucleotide-Mediated Genome Editing Provides Precision and Function to Engineered Nucleases and Antibiotics in Plants by Sauer, Noel J., Narváez-Vásquez, Javier, Mozoruk, Jerry, Miller, Ryan B., Warburg, Zachary J., Woodward, Melody J., Mihiret, Yohannes A., Lincoln, Tracey A., Segami, Rosa E., Sanders, Steven L., Walker, Keith A., Beetham, Peter R., Schöpke, Christian R., Gocal, Greg F.W.

“…Here, we report a form of oligonucleotide-directed mutagenesis for precision genome editing in plants that uses single-stranded oligonucleotides (ssODNs) to…”
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Oligonucleotide‐directed mutagenesis for precision gene editing by Sauer, Noel J, Mozoruk, Jerry, Miller, Ryan B, Warburg, Zachary J, Walker, Keith A, Beetham, Peter R, Schöpke, Christian R, Gocal, Greg F. W

“…Differences in gene sequences, many of which are single nucleotide polymorphisms, underlie some of the most important traits in plants. With humanity facing…”
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Lactams as EP4 Prostanoid Receptor Agonists. 3. Discovery of N-Ethylbenzoic Acid 2-Pyrrolidinones as Subtype Selective Agents by Elworthy, Todd R, Brill, Emma R, Chiou, San-San, Chu, Frances, Harris, Jason R, Hendricks, R. Than, Huang, Jane, Kim, Woongki, Lach, Leang K, Mirzadegan, Tara, Yee, Calvin, Walker, Keith A. M

“…Two distinct synthetic schemes were applied to access heteroatom-containing α-chain lactams or lactams terminated as aryl acids. The latter lactams were…”
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Highly potent, non-basic 5-HT6 ligands. Site mutagenesis evidence for a second binding mode at 5-HT6 for antagonism by Harris, Ralph N., Stabler, Russel S., Repke, David B., Kress, James M., Walker, Keith A., Martin, Renee S., Brothers, Julie M., Ilnicka, Mariola, Lee, Simon W., Mirzadegan, Tara

“…A series of 5-HT6 ligands derived from (R)-1-(amino)methyl-6-(phenyl)sulfonyltetralin was prepared that yielded several neutral, non-basic analogs having…”
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Stereoisomers of ketoconazole: preparation and biological activity by Rotstein, David M, Kertesz, Denis J, Walker, Keith A. M, Swinney, David C

“…The four stereoisomers of the antifungal agent ketoconazole (1) were prepared and evaluated for their selectivity in inhibiting a number of cytochrome P-450…”
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Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors by Campbell, Jeffrey A., Bordunov, Viola, Broka, Chris A., Browner, Michelle F., Kress, James M., Mirzadegan, Tara, Ramesha, Chakk, Sanpablo, Bong F., Stabler, Russell, Takahara, Patricia, Villasenor, Armando, Walker, Keith A.M., Wang, Jin-Hai, Welch, Mary, Weller, Paul

“…The introduction of 3-arylmethyl, 3-aryloxy and 3-arylthio moieties into a 6-methylsulfonylindole framework using rational drug design led to potent, selective…”
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A revised mechanism for the Mitsunobu reaction by Varasi, Mario, Walker, Keith A. M, Maddox, Michael L

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Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs by Chen, Jian Jeffrey, Dewdney, Nolan, Lin, Xiaohong, Martin, Robert L, Walker, Keith A.M, Huang, Jane, Chu, Frances, Eugui, Elsie, Mirkovich, Anna, Kim, Yong, Sarma, Keshab, Arzeno, Humberto, Van Wart, Harold E

“…A novel series of TNF inhibitors was identified based on the screening of existing MMP inhibitor libraries. Further SAR optimization led to the discovery of a…”
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Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains by DANKWARDT, Sharon M, ABBOT, Sarah C, BROKA, Chris A, MARTIN, Robert L, CHAN, Christine S, SPRINGMAN, Eric B, VAN WART, Harold E, WALKER, Keith A. M

“…Optimization of the amino acid side chain and the N-alkyl group of the sulfonamide of amino acid derived sulfonamide hydroxamates is discussed. The solid-phase…”
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Somatic seeds: encapsulation of asexual plant embryos by Redenbaugh, Keith, Paasch, Brian D, Nichol, James W, Kossler, Mary E, Viss, Peter R, Walker, Keith A

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Synthesis of analogs of prostacyclin containing a thiazole ring by Bradbury, Robert H, Walker, Keith A. M

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3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase by Martinez, Gregory R, Walker, Keith A. M, Hirschfeld, Donald R, Bruno, John J, Yang, Diana S, Maloney, Patrick J

“…A series of 1H-imidazol-1-yl- and 3-pyridyl-substituted 3,4-dihydroquinolin-2(1H)-ones was designed and synthesized as combined inhibitors of thromboxane…”
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Antitrichomonal activity of mesoionic thiazolo[3,2-a]pyridines by Walker, Keith A. M, Sjogren, Eric B, Matthews, Thomas R

“…Screening of mesoionic compounds as potential electron acceptors by analogy with metronidazole led to the finding of in vitro antitrichomonal activity for…”
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Stereochemical Consequences of 6- and 8-Substitution in Reactions of Bicyclo[4.2.0]octan-7-ones by Wu, Helen Y, Walker, Keith A. M, Nelson, Janis T

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Effects of 16-heterosubstitution on the regiochemistry of the D-homo rearrangement by Bischofberger, Norbert, Walker, Keith A. M

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Selective Inhibition of Mammalian Lanosterol 14.alpha.-Demethylase by RS-21607 in vitro and in vivo by Swinney, David C, So, On-Yee, Watson, David M, Berry, Pamela W, Webb, Austin S, Kertesz, Denis J, Shelton, Emma J, Walker, Keith A. M, Burton, Pamela M

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Unexpected cis-openings of cyclopentadiene monoepoxide with lithium acetylides and dialkylalkynylalanes by Briggs, Andrew J, Walker, Keith A. M

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Selective inhibition of mammalian lanosterol 14.alpha.-demethylase: a possible strategy for cholesterol lowering by Walker, Keith A. M, Kertesz, Denis J, Rotstein, David M, Swinney, David C, Berry, Pamela W, So, On Yee, Webb, Austin S, Watson, David M, Mak, Amy Y

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Highly potent, non-basic 5-HT sub(6) ligands. Site mutagenesis evidence for a second binding mode at 5-HT sub(6) for antagonism by Harris, Ralph N, Stabler, Russel S, Repke, David B, Kress, James M, Walker, Keith A, Martin, Renee S, Brothers, Julie M, Ilnicka, Mariola, Lee, Simon W, Mirzadegan, Tara

“…A series of 5-HT sub(6) ligands derived from (R)-1-(amino)methyl-6-(phenyl)sulfonyltetralin was prepared that yielded several non-basic analogs having…”
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