Search Results - "Walker, John S"

The Troponin C G159D Mutation Blunts Myofilament Desensitization Induced by Troponin I Ser23/24 Phosphorylation by Biesiadecki, Brandon J, Kobayashi, Tomoyoshi, Walker, John S, Solaro, R John, de Tombe, Pieter P

“…Striated muscle contraction is regulated by the binding of Ca to the N-terminal regulatory lobe of the cardiac troponin C (cTnC) subunit in the troponin…”
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Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice by Walker, Lori A, Walker, John S, Ambler, S. Kelly, Buttrick, Peter M

“…Abstract The response of cardiac muscle to an insult such as myocardial infarction includes changes in the expression of numerous signaling proteins and…”
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Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice by McKee, Laurel A.K., Chen, Hao, Regan, Jessica A., Behunin, Samantha M., Walker, Jeffery W., Walker, John S., Konhilas, John P.

“…► 10–12Month HCM females develop proportionately larger hearts than HCM males. ► HCM females display alterations in Ca2+-sensitivity over female WT; HCM males…”
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Impact of osmotic compression on sarcomere structure and myofilament calcium sensitivity of isolated rat myocardium by Farman, Gerrie P, Walker, John S, de Tombe, Pieter P, Irving, Thomas C

“…Changes in interfilament lattice spacing have been proposed as the mechanism underlying myofilament length-dependent activation. Much of the evidence to…”
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Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy by Nakano, Stephanie J, Walker, John S, Walker, Lori A, Li, Xiaotao, Du, Yanmei, Miyamoto, Shelley D, Sucharov, Carmen C, Garcia, Anastacia M, Mitchell, Max B, Ambardekar, Amrut V, Stauffer, Brian L

“…Dilated cardiomyopathy (DCM) is the most common cause of heart failure (HF) in children, resulting in high mortality and need for heart transplantation. The…”
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Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils by Walker, John S, Walker, Lori A, Margulies, Ken, Buttrick, Peter, de Tombe, Pieter

“…We investigated the effect of PKA treatment (1 U/ml) on the mechanical properties of isolated human cardiac myofibrils. PKA treatment was associated with…”
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Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support by Ambardekar, Amrut V, Walker, John S, Walker, Lori A, Cleveland, Jr, Joseph C, Lowes, Brian D, Buttrick, Peter M

“…Unloading a failing heart with a left ventricular assist device (LVAD) can improve ejection fraction (EF) and LV size; however, recovery with LVAD explantation…”
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Alignment of multi-layered muscle cells within three-dimensional hydrogel macrochannels by Hume, Stephanie L., Hoyt, Sarah M., Walker, John S., Sridhar, Balaji V., Ashley, John F., Bowman, Christopher N., Bryant, Stephanie J.

“…This work describes the development and testing of poly(ethylene glycol) (PEG) hydrogels with independently controlled dimensions of wide and deep…”
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Analysing force-pCa curves by Walker, John S, Li, Xiaotao, Buttrick, Peter M

“…We investigated three forms of the Hill equation used to fit force-calcium data from skinned muscle experiments; Two hyperbolic forms that relate force to…”
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Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension by Walker, Lori A, Walker, John S, Glazier, Amelia, Brown, Dale R, Stenmark, Kurt R, Buttrick, Peter M

“…Right ventricular (RV) failure is one of the strongest predictors of mortality both in the presence of left ventricular decompensation and in the context of…”
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Su1853 Eosinophil's Influence on Colonic Smooth Muscle Contractility by Robinson, Zach D, Masterson, Joanne C, Walker, John S, Lee, James J, Furuta, Glenn

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Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics by de Tombe, Pieter P, Belus, Alexandra, Piroddi, Nicoletta, Scellini, Beatrice, Walker, John S, Martin, Anne F, Tesi, Chiara, Poggesi, Corrado

“…We employed single myofibril techniques to test whether the presence of slow skeletal troponin-I (ssTnI) is sufficient to induce increased myofilament calcium…”
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Glass microneedles for force measurements: a finite-element analysis model by Ayittey, Peter N., Walker, John S., Rice, Jeremy J., de Tombe, Pieter P.

“…Changes in developed force (0.1–3.0 μN) observed during contraction of single myofibrils in response to rapidly changing calcium concentrations can be measured…”
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Tissue procurement strategies affect the protein biochemistry of human heart samples by Walker, Lori A, Medway, Allen M, Walker, John S, Cleveland, Joseph C. Jr, Buttrick, Peter M

“…The ability to analyze the biochemical properties of human cardiac tissue is critical both to an understanding of cardiac pathology and also to the development…”
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AFos inhibits phenylephrine-mediated contractile dysfunction by altering phospholamban phosphorylation by Jeong, Mark Y, Walker, John S, Brown, R Dale, Moore, Russell L, Vinson, Charles S, Colucci, Wilson S, Long, Carlin S

“…Using neonatal rat ventricular myocytes, we previously reported that the expression of a dominant negative form of the c-Fos proto-oncogene (AFos) inhibited…”
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Strong-field electromagnetic stirring in the vertical gradient freeze process with a submerged heater by Ma, Nancy, Walker, John S.

“…This paper treats a steady, axisymmetric melt motion due to electromagnetic (EM) stirring during vertical gradient freeze crystal growth with a submerged…”
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The effect of myosin regulatory light chain phosphorylation on the frequency-dependent regulation of cardiac function by Dias, Fernando A.L., Walker, Lori A., Arteaga, Grace M., Walker, John S., Vijayan, Kalpana, Peña, James R., Ke, Yunbo, Fogaca, Rosalvo T.H., Sanbe, Atsushi, Robbins, Jeffrey, Wolska, Beata M.

“…Although it has been suggested that in cardiac muscle the phosphorylation level of myosin regulatory light chain (RLC) correlates with frequency of…”
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Partial Recovery of Myocyte Contractile Function with Left Ventricular Assist Device Support in Patients with Nonischemic Cardiomyopathy by Ambardekar, Amrut V, Walker, John S, Walker, Lori A, Cleveland, Joseph C, Lowes, Brian D, Buttrick, Peter M

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Titin and the Developing Heart by Walker, John S, de Tombe, Pieter P

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Absence of force suppression in rabbit bladder correlates with low expression of heat shock protein 20 by Batts, Timothy W, Walker, John S, Murphy, Richard A, Rembold, Christopher M

“…Nitroglycerin can induce relaxation of swine carotid artery without sustained reductions in [Ca2+]i or myosin regulatory light chain (MRLC) phosphorylation…”
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