Search Results - "Walker, Joel R"

An optimized bioluminescent substrate for non-invasive imaging in the brain by Su, Yichi, Walker, Joel R., Hall, Mary P., Klein, Mark A., Wu, Xiang, Encell, Lance P., Casey, Kerriann M., Liu, Lan Xiang, Hong, Guosong, Lin, Michael Z., Kirkland, Thomas A.

“…Bioluminescence imaging (BLI) allows non-invasive visualization of cells and biochemical events in vivo and thus has become an indispensable technique in…”
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Evaluation of NanoLuc substrates for bioluminescence imaging of transferred cells in mice by Gaspar, Natasa, Walker, Joel R., Zambito, Giorgia, Marella-Panth, Kranthi, Lowik, Clemens, Kirkland, Thomas A., Mezzanotte, Laura

“…NanoLuc luciferase recently gained popularity due to its small size and superior bioluminescence performance. For in vivo imaging applications, NanoLuc has…”
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Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms by Grohmann, Christoph, Magtoto, Charlene M., Walker, Joel R., Chua, Ngee Kiat, Gabrielyan, Anna, Hall, Mary, Cobbold, Simon A., Mieruszynski, Stephen, Brzozowski, Martin, Simpson, Daniel S., Dong, Hao, Dorizzi, Bridget, Jacobsen, Annette V., Morrish, Emma, Silke, Natasha, Murphy, James M., Heath, Joan K., Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Lessene, Guillaume, Silke, John, Feltham, Rebecca

“…Modulation of protein abundance using t ag- T argeted P rotein D egrader (tTPD) systems targeting FKBP12 F36V (dTAGs) or HaloTag7 (HaloPROTACs) are powerful…”
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Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression by Carossino, Mariano, Kenney, Devin, O'Connell, Aoife K, Montanaro, Paige, Tseng, Anna E, Gertje, Hans P, Grosz, Kyle A, Ericsson, Maria, Huber, Bertrand R, Kurnick, Susanna A, Subramaniam, Saravanan, Kirkland, Thomas A, Walker, Joel R, Francis, Kevin P, Klose, Alexander D, Paragas, Neal, Bosmann, Markus, Saeed, Mohsan, Balasuriya, Udeni B R, Douam, Florian, Crossland, Nicholas A

“…Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing…”
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Optogenetic Control of Non‐Apoptotic Cell Death by He, Lian, Huang, Zixian, Huang, Kai, Chen, Rui, Nguyen, Nhung T., Wang, Rui, Cai, Xiaoli, Huang, Zhiquan, Siwko, Stefan, Walker, Joel R., Han, Gang, Zhou, Yubin, Jing, Ji

“…Herein, a set of optogenetic tools (designated LiPOP) that enable photoswitchable necroptosis and pyroptosis in live cells with varying kinetics, is…”
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NanoBiT System and Hydrofurimazine for Optimized Detection of Viral Infection in Mice-A Novel in Vivo Imaging Platform by Gaspar, Natasa, Zambito, Giorgia, Dautzenberg, Iris J C, Cramer, Steve J, Hoeben, Rob C, Lowik, Clemens, Walker, Joel R, Kirkland, Thomas A, Smith, Thomas P, van Weerden, Wytske M, de Vrij, Jeroen, Mezzanotte, Laura

“…Reporter genes are used to visualize intracellular biological phenomena, including viral infection. Here we demonstrate bioluminescent imaging of viral…”
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Optimized in vivo multispectral bioluminescent imaging of tumor biology using engineered BRET reporters by Labra, Bryan, Parag-Sharma, Kshitij, Powers, John J., Srivastava, Sonal, Walker, Joel R., Kirkland, Thomas A., Brennan, Caroline K., Prescher, Jennifer A., Amelio, Antonio L.

“…The ability to visualize and track multiple biological processes in vivo in real time is highly desirable. Bioluminescence imaging (BLI) has emerged as an…”
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In Vitro and In Vivo Analysis of Extracellular Vesicle‐Mediated Metastasis Using a Bright, Red‐Shifted Bioluminescent Reporter Protein by Perez, Gloria I., Broadbent, David, Zarea, Ahmed A., Dolgikh, Benedikt, Bernard, Matthew P., Withrow, Alicia, McGill, Amelia, Toomajian, Victoria, Thampy, Lukose K., Harkema, Jack, Walker, Joel R., Kirkland, Thomas A., Bachmann, Michael H., Schmidt, Jens, Kanada, Masamitsu

“…Cancer cells produce heterogeneous extracellular vesicles (EVs) as mediators of intercellular communication. This study focuses on a novel method to image EV…”
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Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals by Su, Yichi, Walker, Joel R., Park, Yunhee, Smith, Thomas P., Liu, Lan Xiang, Hall, Mary P., Labanieh, Louai, Hurst, Robin, Wang, David C., Encell, Lance P., Kim, Namdoo, Zhang, Feijie, Kay, Mark A., Casey, Kerriann M., Majzner, Robbie G., Cochran, Jennifer R., Mackall, Crystal L., Kirkland, Thomas A., Lin, Michael Z.

“…Sensitive detection of two biological events in vivo has long been a goal in bioluminescence imaging. Antares, a fusion of the luciferase NanoLuc to the orange…”
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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders by Gurney, Mark E, Nugent, Richard A, Mo, Xuesheng, Sindac, Janice A, Hagen, Timothy J, Fox, David, O’Donnell, James M, Zhang, Chong, Xu, Ying, Zhang, Han-Ting, Groppi, Vincent E, Bailie, Marc, White, Ronald E, Romero, Donna L, Vellekoop, A. Samuel, Walker, Joel R, Surman, Matthew D, Zhu, Lei, Campbell, Robert F

“…Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid…”
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Kinase-Modulated Bioluminescent Indicators Enable Noninvasive Imaging of Drug Activity in the Brain by Wu, Yan, Walker, Joel R., Westberg, Michael, Ning, Lin, Monje, Michelle, Kirkland, Thomas A., Lin, Michael Z., Su, Yichi

“…Aberrant kinase activity contributes to the pathogenesis of brain cancers, neurodegeneration, and neuropsychiatric diseases, but identifying kinase inhibitors…”
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Coelenterazine analogues emit red-shifted bioluminescence with NanoLuc by Shakhmin, Anton, Hall, Mary P, Machleidt, Thomas, Walker, Joel R, Wood, Keith V, Kirkland, Thomas A

“…We report the synthesis and characterization of novel coelenterazine analogues that demonstrate a red-shift in their bioluminescent emission with NanoLuc…”
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Synthesis and preliminary chemotherapeutic evaluation of the fully C-linked glucuronide of N-(4-hydroxyphenyl)retinamide by Walker, Joel R., Alshafie, Galal, Nieves, Nirca, Ahrens, Jamie, Clagett-Dame, Margaret, Abou-Issa, Hussein, Curley, Robert W.

“…All- trans retinoic acid analogues such as N-(4-hydroxyphenyl)retinamide (4-HPR) are effective chemopreventive and chemotherapeutic agents but their utility…”
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Three Efficient Methods for Preparation of Coelenterazine Analogues by Shakhmin, Anton, Hall, Mary P., Walker, Joel R., Machleidt, Thomas, Binkowski, Brock F., Wood, Keith V., Kirkland, Thomas A.

“…The growing popularity of bioluminescent assays has highlighted the need for coelenterazine analogues possessing properties tuned for specific applications…”
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Synthesis of isoindolinones via inverse-electron demand Diels–Alder cycloadditions by Huntley, Raymond J., Gurram, Mahender, Walker, Joel R., Jenkins, David M., Robé, Emmanuel J., Ahmed, Feryan

“…A new synthetic method has been developed for the synthesis of 2,4,5-substituted isoindolinones by means of intramolecular inverse-electron demand Diels–Alder…”
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Highly Potent Cell-Permeable and Impermeable NanoLuc Luciferase Inhibitors by Walker, Joel R, Hall, Mary P, Zimprich, Chad A, Robers, Matthew B, Duellman, Sarah J, Machleidt, Thomas, Rodriguez, Jacquelynn, Zhou, Wenhui

“…Novel engineered NanoLuc (Nluc) luciferase being smaller, brighter, and superior to traditional firefly (Fluc) or Renilla (Rluc) provides a great opportunity…”
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Inhibition of Mammary Tumor Growth by a Novel Nontoxic Retinoid: Chemotherapeutic Evaluation of a C-Linked Analog of 4-HPR-Glucuronide by ALSHAFIE, Galal A, WALKER, Joel R, CURLEY, Robert W, CLAGETT-DAME, Margaret, HIGHLAND, Margaret A, NIEVES, Nirca J, STONEROCK, Laura A, ABOU-ISSA, Hussein

“…Previous studies from our laboratory suggest that 4-HPROG, the O-glucuronide derivative of 4-HPR, has improved mammary cancer chemopreventive/ antitumor…”
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Type-2 Isopentenyl Diphosphate Isomerase. Mechanistic Studies with Cyclopropyl and Epoxy Analogues by Johnston, Jonathan B., Walker, Joel R., Rothman, Steven C., Poulter, C. Dale

“…Type-2 isopentenyl diphosphate isomerase, which catalyzes the interconversion of isopentenyl diphosphate and dimethylallyl diphosphate, contains a tightly…”
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Improved synthesis of the C-glucuronide/glycoside of 4-hydroxybenzylretinone (4-HBR) by Cavanaugh, Kathryn R., Narayanasamy, Sureshbabu, Walker, Joel R., Clagett-Dame, Margaret, Curley, Jr, Robert W.

“…Improvements in the synthesis of carbon-linked glucuronide/glucoside conjugates of cancer chemopreventive retinoids have been achieved starting with…”
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Synthesis and Evaluation of Substrate Analogues as Mechanism-Based Inhibitors of Type II Isopentenyl Diphosphate Isomerase by Walker, Joel R, Rothman, Steven C, Poulter, C. Dale

“…Type 2 isopentenyl diphosphate isomerase (IDI-2), which catalyzes the interconversion of isopentenyl diphosphate and dimethylallyl diphosphate, contains a…”
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