Search Results - "Walker, Jennifer A"

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion by Oliphant, Christopher J., Hwang, You Yi, Walker, Jennifer A., Salimi, Maryam, Wong, See Heng, Brewer, James M., Englezakis, Alexandros, Barlow, Jillian L., Hams, Emily, Scanlon, Seth T., Ogg, Graham S., Fallon, Padraic G., McKenzie, Andrew N.J.

“…Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and…”
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The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity by Damgaard, Rune Busk, Walker, Jennifer A., Marco-Casanova, Paola, Morgan, Neil V., Titheradge, Hannah L., Elliott, Paul R., McHale, Duncan, Maher, Eamonn R., McKenzie, Andrew N.J., Komander, David

“…Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators…”
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Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells by Halim, Timotheus Y.F., Rana, Batika M.J., Walker, Jennifer A., Kerscher, Bernhard, Knolle, Martin D., Jolin, Helen E., Serrao, Eva M., Haim-Vilmovsky, Liora, Teichmann, Sarah A., Rodewald, Hans-Reimer, Botto, Marina, Vyse, Timothy J., Fallon, Padraic G., Li, Zhi, Withers, David R., McKenzie, Andrew N.J.

“…The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced…”
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A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue by Rana, Batika M J, Jou, Eric, Barlow, Jillian L, Rodriguez-Rodriguez, Noe, Walker, Jennifer A, Knox, Claire, Jolin, Helen E, Hardman, Clare S, Sivasubramaniam, Meera, Szeto, Aydan, Cohen, E Suzanne, Scott, Ian C, Sleeman, Matthew A, Chidomere, Chiamaka I, Cruz Migoni, Sara, Caamano, Jorge, Jorgensen, Helle F, Carobbio, Stefania, Vidal-Puig, Antonio, McKenzie, Andrew N J

“…Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the…”
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Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow by Walker, Jennifer A., Clark, Paula A., Crisp, Alastair, Barlow, Jillian L., Szeto, Aydan, Ferreira, Ana C.F., Rana, Batika M.J., Jolin, Helen E., Rodriguez-Rodriguez, Noe, Sivasubramaniam, Meera, Pannell, Richard, Cruickshank, James, Daly, Maria, Haim-Vilmovsky, Liora, Teichmann, Sarah A., McKenzie, Andrew N.J.

“…Innate lymphoid cells (ILCs) play strategic roles in tissue homeostasis and immunity. ILCs arise from lymphoid progenitors undergoing lineage restriction and…”
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Bcl11b is essential for group 2 innate lymphoid cell development by Walker, Jennifer A, Oliphant, Christopher J, Englezakis, Alexandros, Yu, Yong, Clare, Simon, Rodewald, Hans-Reimer, Belz, Gabrielle, Liu, Pentao, Fallon, Padraic G, McKenzie, Andrew N J

“…Group 2 innate lymphoid cells (ILC2s) are often found associated with mucosal surfaces where they contribute to protective immunity, inappropriate allergic…”
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Type-2 innate lymphoid cells control the development of atherosclerosis in mice by Newland, Stephen A., Mohanta, Sarajo, Clément, Marc, Taleb, Soraya, Walker, Jennifer A., Nus, Meritxell, Sage, Andrew P., Yin, Changjun, Hu, Desheng, Kitt, Lauren L., Finigan, Alison J., Rodewald, Hans-Reimer, Binder, Christoph J., McKenzie, Andrew N. J., Habenicht, Andreas J., Mallat, Ziad

“…Type-2 innate lymphoid cells (ILC2) are a prominent source of type II cytokines and are found constitutively at mucosal surfaces and in visceral adipose…”
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Plasma cell development and survival by Oracki, Sarah A, Walker, Jennifer A, Hibbs, Margaret L, Corcoran, Lynn M, Tarlinton, David M

“…Plasma cells have long been recognized as the basis of humoral immunity, yet we are only now beginning to appreciate the complexities of plasma cell…”
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Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors by Clark, Paula A., Gogoi, Mayuri, Rodriguez-Rodriguez, Noe, Ferreira, Ana C. F., Murphy, Jane E., Walker, Jennifer A., Crisp, Alastair, Jolin, Helen E., Shields, Jacqueline D., McKenzie, Andrew N. J.

“…Innate lymphoid cells (ILCs) are critical in maintaining tissue homeostasis, and during infection and inflammation. Here we identify, by using combinatorial…”
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Mapping Rora expression in resting and activated CD4+ T cells by Haim-Vilmovsky, Liora, Henriksson, Johan, Walker, Jennifer A, Miao, Zhichao, Natan, Eviatar, Kar, Gozde, Clare, Simon, Barlow, Jillian L, Charidemou, Evelina, Mamanova, Lira, Chen, Xi, Proserpio, Valentina, Pramanik, Jhuma, Woodhouse, Steven, Protasio, Anna V, Efremova, Mirjana, Griffin, Julian L, Berriman, Matt, Dougan, Gordon, Fisher, Jasmin, Marioni, John C, McKenzie, Andrew N J, Teichmann, Sarah A

“…The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we…”
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Age-induced changes in anti-tumor immunity alter the tumor immune infiltrate and impact response to immuno-oncology treatments by Sitnikova, Suzanne I., Walker, Jennifer A., Prickett, Laura B., Morrow, Michelle, Valge-Archer, Viia E., Robinson, Matthew J., Wilkinson, Robert W., Dovedi, Simon J.

“…Introduction Immuno-oncology (IO) research relies heavily on murine syngeneic tumor models. However, whilst the average age for a cancer diagnosis is 60 years…”
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CD22: an inhibitory enigma by Walker, Jennifer A, Smith, Kenneth G.C

“…CD22 is an inhibitory coreceptor of the B-cell receptor (BCR), and plays a critical role in establishing signalling thresholds for B-cell activation. Like…”
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Group 2 Innate Lymphoid Cells Exhibit Tissue-Specific Dynamic Behaviour During Type 2 Immune Responses by Lok, Laurence S C, Walker, Jennifer A, Jolin, Helen E, Scanlon, Seth T, Ishii, Masaru, Fallon, Padraic G, McKenzie, Andrew N J, Clatworthy, Menna R

“…Group 2 innate lymphoid cells (ILC2s) are early effectors of mucosal type 2 immunity, producing cytokines such as interleukin (IL)-13 to mediate responses to…”
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Innate lymphoid cells in the airways by Walker, Jennifer A., McKenzie, Andrew

“…The airways, similar to other mucosal surfaces, are continuously exposed to the outside environment and a barrage of antigens, allergens, and microorganisms…”
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The PICALM protein plays a key role in iron homeostasis and cell proliferation by Scotland, Paula B, Heath, Jessica L, Conway, Amanda E, Porter, Natasha B, Armstrong, Michael B, Walker, Jennifer A, Klebig, Mitchell L, Lavau, Catherine P, Wechsler, Daniel S

“…The ubiquitously expressed phosphatidylinositol binding clathrin assembly (PICALM) protein associates with the plasma membrane, binds clathrin, and plays a…”
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TH2 cell development and function by Walker, Jennifer A., McKenzie, Andrew N. J.

“…Key Points T helper 2 (T H 2) cells respond to a variety of environmental cues, either directly or indirectly through interaction with cells of the innate…”
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Innate lymphoid cells — how did we miss them? by Walker, Jennifer A., Barlow, Jillian L., McKenzie, Andrew N. J.

“…Key Points Innate lymphoid cells (ILCs) are newly identified members of the lymphoid lineage with emerging roles in mediating immune responses and in…”
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Development and function of group 2 innate lymphoid cells by Walker, Jennifer A, McKenzie, Andrew NJ

“…Highlights ► ILC2 provide an innate source of type-2 cytokines (IL-5, IL-9 and IL-13). ► IL-13 production by ILC2 is critical to anti-helminthic immunity. ►…”
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Hypothyroid-Induced Rhabdomyolysis: A Case Report by Walker, Jennifer A, Miles, Zachary

“…Patients frequently present to the emergency department (ED) with non-specific complaints such as body aches and generalized weakness, which can have an…”
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Transcription factor RORα is critical for nuocyte development by Wong, See Heng, Walker, Jennifer A, Jolin, Helen E, Drynan, Lesley F, Hams, Emily, Camelo, Ana, Barlow, Jillian L, Neill, Daniel R, Panova, Veera, Koch, Ute, Radtke, Freddy, Hardman, Clare S, Hwang, You Yi, Fallon, Padraic G, McKenzie, Andrew N J

“…Nuocytes are innate cells with critical roles during infection with parasitic worms. McKenzie and colleagues show that nuocytes differentiate from common…”
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