Search Results - "Walker, Janek S"

Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation by Hing, Zachary A., Walker, Janek S., Whipp, Ethan C., Brinton, Lindsey, Cannon, Matthew, Zhang, Pu, Sher, Steven, Cempre, Casey B., Brown, Fiona, Smith, Porsha L., Agostinelli, Claudio, Pileri, Stefano A., Skinner, Jordan N., Williams, Katie, Phillips, Hannah, Shaffer, Jami, Beaver, Larry P., Pan, Alexander, Shin, Kyle, Gregory, Charles T., Ozer, Gulcin H., Yilmaz, Selen A., Harrington, Bonnie K., Lehman, Amy M., Yu, Lianbo, Coppola, Vincenzo, Yan, Pearlly, Scherle, Peggy, Wang, Min, Pitis, Philip, Xu, Chaoyi, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer, Blachly, James S., Alinari, Lapo, Yang, Yiping, Byrd, John C., Baiocchi, Robert A., Blaser, Bradley W., Lapalombella, Rosa

“…Richter’s Transformation (RT) is a poorly understood and fatal progression of chronic lymphocytic leukemia (CLL) manifesting histologically as diffuse large…”
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Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia by Walker, Janek S, Hing, Zachary A, Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N, Cempre, Casey B, Sun, Qingxiang, Shacham, Sharon, Stromberg, Benjamin R, Summers, Matthew K, Abruzzo, Lynne V, Rassenti, Laura, Kipps, Thomas J, Parikh, Sameer, Kay, Neil E, Rogers, Kerry A, Woyach, Jennifer A, Coppola, Vincenzo, Chook, Yuh Min, Oakes, Christopher, Byrd, John C, Lapalombella, Rosa

“…Exportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome…”
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Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia by Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Pan, Alexander, Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrózek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Yan, Pearlly, Byrd, John C., Blachly, James S., Lapalombella, Rosa

“…Rare, recurrent balanced translocations occur in a variety of cancers but are often not functionally interrogated. Balanced translocations with the…”
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Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL by Wenzl, Kerstin, Stokes, Matthew E., Novak, Joseph P., Bock, Allison M., Khan, Sana, Hopper, Melissa A., Krull, Jordan E., Dropik, Abigail R., Walker, Janek S., Sarangi, Vivekananda, Mwangi, Raphael, Ortiz, Maria, Stong, Nicholas, Huang, C. Chris, Maurer, Matthew J., Rimsza, Lisa, Link, Brian K., Slager, Susan L., Asmann, Yan, Mondello, Patrizia, Morin, Ryan, Ansell, Stephen M., Habermann, Thomas M., Witzig, Thomas E., Feldman, Andrew L., King, Rebecca L., Nowakowski, Grzegorz, Cerhan, James R., Gandhi, Anita K., Novak, Anne J.

“…Recent genetic and molecular classification of DLBCL has advanced our knowledge of disease biology, yet were not designed to predict early events and guide…”
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DEK regulates B-cell proliferative capacity and is associated with aggressive disease in low-grade B-cell lymphomas by Hopper, Melissa A., Dropik, Abigail R., Walker, Janek S., Novak, Joseph P., Laverty, Miranda S., Manske, Michelle K., Wu, Xiaosheng, Wenzl, Kerstin, Krull, Jordan E., Sarangi, Vivekananda, Maurer, Matthew J., Yang, Zhi-Zhang, Del Busso, Miles D., Habermann, Thomas M., Link, Brian K., Rimsza, Lisa M., Witzig, Thomas E., Ansell, Stephen M., Cerhan, James R., Jevremovic, Dragan, Novak, Anne J.

“…This study sheds light on the pivotal role of the oncoprotein DEK in B-cell lymphoma. We reveal DEK expression correlates with increased tumor proliferation…”
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Selinexor for advanced hematologic malignancies by Walker, Janek S., Garzon, Ramiro, Lapalombella, Rosa

“…Recent measures to classify novel molecular targets with therapeutic potential across multiple hematologic tumors have identified the eukaryotic nuclear…”
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Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation by Baumhardt, Jordan M, Walker, Janek S, Lee, Yoonji, Shakya, Binita, Brautigam, Chad A, Lapalombella, Rosa, Grishin, Nick, Chook, Yuh Min

“…The E571K mutation of CRM1 is highly prevalent in some cancers, but its mechanism of tumorigenesis is unclear. Glu571 of CRM1 is located in its nuclear export…”
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Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study by Stephens, Deborah M, Huang, Ying, Ruppert, Amy S, Walker, Janek S, Canfield, Daniel, Cempre, Casey B, Fu, Qiang, Baker, Sharyn, Hu, Boyu, Shah, Harsh, Vadeboncoeur, Renee, Rogers, Kerry A, Bhat, Seema, Jaglowski, Samantha M, Lockman, Hank, Lapalombella, Rosa, Byrd, John C, Woyach, Jennifer A

“…Dual blockade of Bruton's tyrosine kinase with ibrutinib and selinexor has potential to deepen responses for patients with chronic lymphocytic leukemia (CLL)…”
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Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor–mediated synergistic antileukemic actions by Zhang, Pu, Brinton, Lindsey T., Gharghabi, Mehdi, Sher, Steven, Williams, Katie, Cannon, Matthew, Walker, Janek S., Canfield, Daniel, Beaver, Larry, Cempre, Casey B., Phillips, Hannah, Chen, Xuyong, Yan, Pearlly, Lehman, Amy, Scherle, Peggy, Wang, Min, Vaddi, Kris, Baiocchi, Robert, Wang, Ruoning, Sampath, Deepa, Alinari, Lapo, Blachly, James S., Lapalombella, Rosa

“…Using a genome-wide CRISPR screen, we identified CDK9 , DHODH , and PRMT5 as synthetic lethal partners with gilteritinib treatment in fms-like tyrosine kinase…”
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Cooperative Somatic Alterations in XPO1 and TNFAIP3 (A20) Promote Immune Modulation and Tissue Infiltration in Primary Mediastinal B Cell Lymphoma by Whipp, Ethan C., Walker, Janek S., Gharghabi, Mehdi, Cempre, Casey, Walker, Brandi, Lapalombella, Rosa

“…Background: Primary Mediastinal B cell lymphoma (PMBCL) is an aggressive large B cell non-Hodgkin lymphoma typically presenting as a mass in the anterior…”
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Simultaneous Disruption of XPO1 and A20 in Murine B Cells Influences Both B and T Cell Repertoire by Walker, Janek S., Cempre, Casey B., Skinner, Jordan N., Walker, Brandi R., Byrd, John C., Lapalombella, Rosa

“…Introduction & Objectives: Efforts to characterize the heterogeneity of advanced hematologic malignancies using large-scale genomic studies have identified…”
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Truncating SPEN Mutations Highlight BN2-Subtype DLBCL with Aggressive Biology and Features of Immune Evasion by Walker, Janek S., Wenzl, Kerstin, Novak, Joseph P., Manske, Michelle, Serres, Makayla, Bock, Allison M., Hopper, Melissa A., Krull, Jordan Edward, Dropik, Abigail R., Laverty, Miranda S., Sarangi, Vivekananda, Maurer, Matthew J., Rimsza, Lisa M., Link, Brian K., Habermann, Thomas M., King, Rebecca L., Ansell, Stephen M, Witzig, Thomas E., Nowakowski, Grzegorz S., Cerhan, James R., Novak, Anne J.

“…Introduction: Molecular classifications have been developed to characterize the heterogeneity of diffuse large B cell lymphoma (DLBCL), with activation of BCL6…”
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DEK Regulates B-Cell Proliferative Capacity and Is Associated with Aggressive Disease in Low-Grade B-Cell Lymphoma by Hopper, Melissa A., Dropik, Abigail R., Walker, Janek S., Novak, Joseph P., Laverty, Miranda S., Manske, Michelle, Wu, Xiaosheng, Wenzl, Kerstin, Krull, Jordan Edward, Sarangi, Vivekananda, Maurer, Matthew J., Habermann, Thomas M., Link, Brian K., Rimsza, Lisa M., Witzig, Thomas E., Ansell, Stephen M, Cerhan, James R., Jevremovic, Dragan, Novak, Anne J.

“…Introduction: Non-Follicular Low-Grade B-Cell Lymphomas (LGBCL) are a subset of lymphomas that share overlapping clinical and histologic features. While most…”
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Molecular Classification of Relapsed DLBCL Reveals Novel Biologic Subgroups by Wenzl, Kerstin, Stokes, Matthew E, Novak, Joseph P., Bock, Allison M., Hopper, Melissa A., Krull, Jordan, Dropik, Abigail R., Walker, Janek S., Laverty, Miranda S., Sarangi, Vivekananda, Mwangi, Raphael, Ortiz, Maria, Stong, Nicholas, Huang, C. Chris, Maurer, Matthew J., Rimsza, Lisa M., Link, Brian K., King, Rebecca, Ansell, Stephen M, Habermann, Thomas M., Witzig, Thomas E., Nowakowski, Grzegorz S., Cerhan, James R., Gandhi, Anita K., Novak, Anne J.

“…Background Diffuse large B cell lymphoma (DLBCL) is the most common aggressive lymphoid malignancy in adults. Though standard immunochemotherapy regimens can…”
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Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel Gilteritinib Combinations Targeting Oxidative Phosphorylation and De-Novo Purine Biosynthesis Pathways for FLT3-ITD+ Acute Myeloid Leukemia by Sher, Steven, Zhang, Pu, Brinton, Lindsey, Gharghabi, Mehdi, Williams, Katie, Cannon, Matthew, Walker, Janek S., Canfield, Daniel, Beaver, Larry, Cempre, Casey B., Phillips, Hannah, Chen, Xuyong, Yan, Pearlly S., Lehman, Amy M., Scherle, Peggy, Wang, Min, Vaddi, Kris, Baiocchi, Robert A., Wang, Ruoning, Sampath, Deepa, Alinari, Lapo, Blachly, James S., Lapalombella, Rosa

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Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Supports Transformation to Diffuse Large B-Cell Lymphoma by Whipp, Ethan, Hing, Zachary A, Walker, Janek S., Sher, Steven, Cempre, Casey B., Brown, Fiona, Agostinelli, Claudio, Pileri, Stefano A, Williams, Katie, Beaver, Larry, Pan, Alexander, Gregory, Charles T., Yan, Pearlly S., Scherle, Peggy, Wang, Min, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer A., Blachly, James S., Alinari, Lapo, Yang, Yiping, Baiocchi, Robert A., Blaser, Bradley W, Lapalombella, Rosa

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Abstract 2260: Evaluating a rare t(X;14)(q28;q32) translocation reveals MTCP1 as a driving factor in chronic lymphocytic leukemia by Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrozek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Byrd, John C., Blachly, James S., Lapalombella, Rosa

“…Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in Western countries and is spelled by substantial genetic and clinical heterogeneity…”
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