Search Results - "Walker, Caitlin"
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Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis
Published in Frontiers in neuroscience (15-11-2021)“…Cognitive fatigability is an objective performance decrement that occurs over time during a task requiring sustained cognitive effort. Although cognitive…”
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The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A
Published in eLife (24-06-2024)“…Allosteric cooperativity between ATP and substrates is a prominent characteristic of the cAMP-dependent catalytic subunit of protein kinase A (PKA-C). This…”
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3
Probing Protein-Protein Interactions Using Asymmetric Labeling and Carbonyl-Carbon Selective Heteronuclear NMR Spectroscopy
Published in Molecules (Basel, Switzerland) (03-08-2018)“…Protein-protein interactions (PPIs) regulate a plethora of cellular processes and NMR spectroscopy has been a leading technique for characterizing them at the…”
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Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
Published in Communications biology (10-03-2021)“…An aberrant fusion of the DNAJB1 and PRKACA genes generates a chimeric protein kinase (PKA-C DNAJB1 ) in which the J-domain of the heat shock protein 40 is…”
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5
Unsettling the Classification of Nature, Culture and History
Published in Museum and society (17-07-2019)“…This paper examines the implications of the categorical separation between Nature, Culture and History that is common in Western museums. It focuses on the…”
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Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A
Published in Communications biology (06-04-2021)“…A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-02006-3…”
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A case series and literature review of blastomycosis during pregnancy amidst the COVID-19 crisis
Published in International journal of gynecology and obstetrics (01-11-2023)“…Blastomycosis dermatitidis is a rare fungus known for is classic mimicry of pneumonia, lung cancer, and mycobacterial infections. Whilst it is known best for…”
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A comparison of effort-based decision making for social and monetary rewards in older adults at risk for Alzheimer's disease
Published in Journal of the neurological sciences (01-12-2023)Get full text
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9
Holocene Eolian Sediment and Organic Matter from Terraces and Hillslopes Around Healy, Central Alaska
Published 01-01-2023“…As the most widespread surficial sediment in Alaska, eolian sediment plays an important role in burying organic matter, the aggradation of surficial sediment,…”
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Dissertation -
10
The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells
Published in Nature (London) (13-04-2023)“…Natural killer (NK) cells kill infected, transformed and stressed cells when an activating NK cell receptor is triggered 1 . Most NK cells and some innate…”
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An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP‐dependent protein kinase A
Published in FEBS letters (01-04-2023)“…The cAMP‐dependent protein kinase A (PKA) is the archetypical eukaryotic kinase. The catalytic subunit (PKA‐C) structure is highly conserved among the…”
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12
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D
Published in Nature (London) (13-06-2024)“…Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation and was previously shown to form large…”
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13
Using Clean Language Interviewing to Model Curriculum Design in Higher Education: Curriculum Design Is Like What?
Published 01-01-2021“…The design of the curriculum within Higher Education affects hundreds of thousands of students each year. Yet it is complex, messy and under-researched. Whilst…”
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Dissertation -
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Probing the Structural and Biochemical Basis for the Development of Cushing's Syndrome caused by a Somatic Mutant of Protein Kinase A
Published in The FASEB journal (01-04-2017)“…Abstract only Protein phosphorylation is a ubiquitously conserved signaling mechanism playing a crucial role in activating or deactivating vital cellular…”
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Journal Article -
15
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A
Published in eLife (24-06-2024)“…Allosteric cooperativity between ATP and substrates is a prominent characteristic of the cAMP-dependent catalytic subunit of protein kinase A (PKA-C). This…”
Get full text
Journal Article -
16
Publisher Correction: The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells
Published in Nature (London) (08-06-2023)Get full text
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17
Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?
Published in Journal of molecular biology (03-09-2021)“…[Display omitted] •A Cushing’s disease mutation of protein kinase A disrupts nucleotide-substrate binding cooperativity.•The E31V mutation attenuates the…”
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A Cushing Syndrome Mutation of Protein Kinase A C‐subunit Disrupts the Internal Allosteric Network Affecting Regulation and Substrate Specificity
Published in The FASEB journal (01-04-2019)“…Genetic alterations of the PRKACA gene coding for the catalytic subunit of the CAMP‐dependent protein kinase A (PKA‐C) are linked to cortisol‐secreting…”
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Neurobehavioral Mechanisms Influencing the Association Between Generativity, the Desire to Promote Well-Being of Younger Generations, and Purpose in Life in Older Adults at Risk for Alzheimer's Disease
Published in The journals of gerontology. Series B, Psychological sciences and social sciences (01-06-2024)“…Generativity, the desire and action to improve the well-being of younger generations, is associated with purpose in life among older adults. However, the…”
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Journal Article -
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On the Role of Allosteric Cooperativity in the Regulation of Protein Kinase A and Its Implications in Disease
Published 01-01-2021“…First articulated half a century ago, allostery has remained a universal phenomenon and is essential in understanding processes beyond the molecular level,…”
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Dissertation