Search Results - "Walker, Bruce D"

HIV and HLA Class I: An Evolving Relationship by Goulder, Philip J.R., Walker, Bruce D.

“…Successful vaccine development for infectious diseases has largely been achieved in settings where natural immunity to the pathogen results in clearance in at…”
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Cervicovaginal Bacteria Are a Major Modulator of Host Inflammatory Responses in the Female Genital Tract by Anahtar, Melis N., Byrne, Elizabeth H., Doherty, Kathleen E., Bowman, Brittany A., Yamamoto, Hidemi S., Soumillon, Magali, Padavattan, Nikita, Ismail, Nasreen, Moodley, Amber, Sabatini, Mary E., Ghebremichael, Musie S., Nusbaum, Chad, Huttenhower, Curtis, Virgin, Herbert W., Ndung’u, Thumbi, Dong, Krista L., Walker, Bruce D., Fichorova, Raina N., Kwon, Douglas S.

“…Colonization by Lactobacillus in the female genital tract is thought to be critical for maintaining genital health. However, little is known about how genital…”
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Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design by Ferguson, Andrew L., Mann, Jaclyn K., Omarjee, Saleha, Ndung’u, Thumbi, Walker, Bruce D., Chakraborty, Arup K.

“…A prophylactic or therapeutic vaccine offers the best hope to curb the HIV-AIDS epidemic gripping sub-Saharan Africa, but it remains elusive. A major challenge…”
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Toward an AIDS Vaccine by Walker, Bruce D, Burton, Dennis R

“…A quarter century of scientific discovery has been applied to developing an AIDS vaccine, yet this goal remains elusive. Specific characteristics of the virus,…”
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PD-1 and CTLA-4 Inhibitory Cosignaling Pathways in HIV Infection and the Potential for Therapeutic Intervention by Kaufmann, Daniel E, Walker, Bruce D

“…The balance between proinflammatory mechanisms and the dampening of excessive immune activation is critical for successful clearance of a pathogen without harm…”
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Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control by Ackerman, Margaret E, Mikhailova, Anastassia, Brown, Eric P, Dowell, Karen G, Walker, Bruce D, Bailey-Kellogg, Chris, Suscovich, Todd J, Alter, Galit

“…Elite controllers (ECs) represent a unique model of a functional cure for HIV-1 infection as these individuals develop HIV-specific immunity able to…”
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Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point by Ndhlovu, Zaza M., Kamya, Philomena, Mewalal, Nikoshia, Kløverpris, Henrik N., Nkosi, Thandeka, Pretorius, Karyn, Laher, Faatima, Ogunshola, Funsho, Chopera, Denis, Shekhar, Karthik, Ghebremichael, Musie, Ismail, Nasreen, Moodley, Amber, Malik, Amna, Leslie, Alasdair, Goulder, Philip J.R., Buus, Søren, Chakraborty, Arup, Dong, Krista, Ndung’u, Thumbi, Walker, Bruce D.

“…CD8+ T cells contribute to the control of HIV, but it is not clear whether initial immune responses modulate the viral set point. We screened high-risk…”
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HIV-1 Integration Landscape during Latent and Active Infection by Cohn, Lillian B., Silva, Israel T., Oliveira, Thiago Y., Rosales, Rafael A., Parrish, Erica H., Learn, Gerald H., Hahn, Beatrice H., Czartoski, Julie L., McElrath, M. Juliana, Lehmann, Clara, Klein, Florian, Caskey, Marina, Walker, Bruce D., Siliciano, Janet D., Siliciano, Robert F., Jankovic, Mila, Nussenzweig, Michel C.

“…The barrier to curing HIV-1 is thought to reside primarily in CD4+ T cells containing silent proviruses. To characterize these latently infected cells, we…”
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The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing by Mann, Jaclyn K, Barton, John P, Ferguson, Andrew L, Omarjee, Saleha, Walker, Bruce D, Chakraborty, Arup, Ndung'u, Thumbi

“…Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational…”
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Immunogenetics of Spontaneous Control of HIV by Carrington, Mary, Walker, Bruce D

“…Host genetic variation is presently estimated to account for about one-fourth of the observed differences in control of HIV across infected individuals…”
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Accelerating Next-Generation Vaccine Development for Global Disease Prevention by Koff, Wayne C., Burton, Dennis R., Johnson, Philip R., Walker, Bruce D., King, Charles R., Nabel, Gary J., Ahmed, Rafi, Bhan, Maharaj K., Plotkin, Stanley A.

“…Vaccines are among the greatest successes in the history of public health. However, past strategies for vaccine development are unlikely to succeed in the…”
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Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals by Baxter, Amy E., Niessl, Julia, Fromentin, Rémi, Richard, Jonathan, Porichis, Filippos, Charlebois, Roxanne, Massanella, Marta, Brassard, Nathalie, Alsahafi, Nirmin, Delgado, Gloria-Gabrielle, Routy, Jean-Pierre, Walker, Bruce D., Finzi, Andrés, Chomont, Nicolas, Kaufmann, Daniel E.

“…HIV cure efforts are hampered by limited characterization of the cells supporting HIV replication in vivo and inadequate methods for quantifying the latent…”
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Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable by Barton, John P., Goonetilleke, Nilu, Butler, Thomas C., Walker, Bruce D., McMichael, Andrew J., Chakraborty, Arup K.

“…Human immunodeficiency virus (HIV) evolves within infected persons to escape being destroyed by the host immune system, thereby preventing effective immune…”
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Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes by Jones, Richard Brad, O'Connor, Rachel, Mueller, Stefanie, Foley, Maria, Szeto, Gregory L, Karel, Dan, Lichterfeld, Mathias, Kovacs, Colin, Ostrowski, Mario A, Trocha, Alicja, Irvine, Darrell J, Walker, Bruce D

“…Resting memory CD4+ T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as…”
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Genetic and Immunologic Heterogeneity among Persons Who Control HIV Infection in the Absence of Therapy by Pereyra, Florencia, Addo, Marylyn M., Kaufmann, Daniel E., Liu, Yang, Miura, Toshiyuki, Rathod, Almas, Baker, Brett, Trocha, Alicja, Rosenberg, Rachel, Mackey, Elizabeth, Ueda, Peggy, Lu, Zhigang, Cohen, Daniel, Wrin, Terri, Petropoulos, Christos J., Rosenberg, Eric S., Walker, Bruce D.

“…Background. Spontaneous control of human immunodeficiency virus (HIV) infection has been documented in a minority of HIV-infected individuals. The mechanisms…”
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HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses by Clayton, Kiera L., Mylvaganam, Geetha, Villasmil-Ocando, Alonso, Stuart, Heather, Maus, Marcela V., Rashidian, Mohammad, Ploegh, Hidde L., Walker, Bruce D.

“…Natural killer (NK) cells are innate cytolytic effectors that target HIV-infected CD4+ T cells. In conjunction with antibodies recognizing the HIV envelope, NK…”
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Reactivation of Latent HIV-1 by Inhibition of BRD4 by Zhu, Jian, Gaiha, Gaurav D., John, Sinu P., Pertel, Thomas, Chin, Christopher R., Gao, Geng, Qu, Hongjing, Walker, Bruce D., Elledge, Stephen J., Brass, Abraham L.

“…HIV-1 depends on many host factors for propagation. Other host factors, however, antagonize HIV-1 and may have profound effects on viral activation. Curing…”
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HIV-1 DNA sequence diversity and evolution during acute subtype C infection by Lee, Guinevere Q., Reddy, Kavidha, Einkauf, Kevin B., Gounder, Kamini, Chevalier, Joshua M., Dong, Krista L., Walker, Bruce D., Yu, Xu G., Ndung’u, Thumbi, Lichterfeld, Mathias

“…Little is known about the genotypic make-up of HIV-1 DNA genomes during the earliest stages of HIV-1 infection. Here, we use near-full-length, single genome…”
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Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination by Mahan, Alison E, Jennewein, Madeleine F, Suscovich, Todd, Dionne, Kendall, Tedesco, Jacquelynne, Chung, Amy W, Streeck, Hendrik, Pau, Maria, Schuitemaker, Hanneke, Francis, Don, Fast, Patricia, Laufer, Dagna, Walker, Bruce D, Baden, Lindsey, Barouch, Dan H, Alter, Galit

“…Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role…”
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Toward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology by Mylvaganam, Geetha, Yanez, Adrienne G, Maus, Marcela, Walker, Bruce D

“…As the AIDS epidemic unfolded, the appearance of opportunistic infections in at-risk persons provided clues to the underlying problem: a dramatic defect in…”
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