Search Results - "Walker, Bruce"

Pilon: an integrated tool for comprehensive microbial variant detection and genome assembly improvement by Walker, Bruce J, Abeel, Thomas, Shea, Terrance, Priest, Margaret, Abouelliel, Amr, Sakthikumar, Sharadha, Cuomo, Christina A, Zeng, Qiandong, Wortman, Jennifer, Young, Sarah K, Earl, Ashlee M

“…Advances in modern sequencing technologies allow us to generate sufficient data to analyze hundreds of bacterial genomes from a single machine in a single day…”
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HIV and HLA Class I: An Evolving Relationship by Goulder, Philip J.R., Walker, Bruce D.

“…Successful vaccine development for infectious diseases has largely been achieved in settings where natural immunity to the pathogen results in clearance in at…”
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CD8+ T cells in HIV control, cure and prevention by Collins, David R., Gaiha, Gaurav D., Walker, Bruce D.

“…HIV infection can be effectively treated by lifelong administration of combination antiretroviral therapy, but an effective vaccine will likely be required to…”
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The AMP Trials — A Glass Half Full by Walker, Bruce D

“…Induction of broadly neutralizing antibodies (bnAbs) is considered the holy grail for a preventive human immunodeficiency virus (HIV) vaccine, but four decades…”
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Cervicovaginal Bacteria Are a Major Modulator of Host Inflammatory Responses in the Female Genital Tract by Anahtar, Melis N., Byrne, Elizabeth H., Doherty, Kathleen E., Bowman, Brittany A., Yamamoto, Hidemi S., Soumillon, Magali, Padavattan, Nikita, Ismail, Nasreen, Moodley, Amber, Sabatini, Mary E., Ghebremichael, Musie S., Nusbaum, Chad, Huttenhower, Curtis, Virgin, Herbert W., Ndung’u, Thumbi, Dong, Krista L., Walker, Bruce D., Fichorova, Raina N., Kwon, Douglas S.

“…Colonization by Lactobacillus in the female genital tract is thought to be critical for maintaining genital health. However, little is known about how genital…”
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Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design by Ferguson, Andrew L., Mann, Jaclyn K., Omarjee, Saleha, Ndung’u, Thumbi, Walker, Bruce D., Chakraborty, Arup K.

“…A prophylactic or therapeutic vaccine offers the best hope to curb the HIV-AIDS epidemic gripping sub-Saharan Africa, but it remains elusive. A major challenge…”
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Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control by Ackerman, Margaret E, Mikhailova, Anastassia, Brown, Eric P, Dowell, Karen G, Walker, Bruce D, Bailey-Kellogg, Chris, Suscovich, Todd J, Alter, Galit

“…Elite controllers (ECs) represent a unique model of a functional cure for HIV-1 infection as these individuals develop HIV-specific immunity able to…”
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Unravelling the mechanisms of durable control of HIV-1 by Walker, Bruce D., Yu, Xu G.

“…Key Points HIV controllers are a small group of HIV-1-infected patients who maintain undetectable or minimal levels of HIV-1 replication in the absence of…”
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InfoSPOT: A mobile Augmented Reality method for accessing building information through a situation awareness approach by Irizarry, Javier, Gheisari, Masoud, Williams, Graceline, Walker, Bruce N.

“…The Architecture, Engineering, Construction, and Owner/Operator (AECO) industry is constantly searching for new methods for increasing efficiency and…”
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HIV-specific CD8⁺ T cells and HIV eradication by Jones, R Brad, Walker, Bruce D

“…After the success of combination antiretroviral therapy (cART) to treat HIV infection, the next great frontier is to cure infected persons, a formidable…”
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The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing by Mann, Jaclyn K, Barton, John P, Ferguson, Andrew L, Omarjee, Saleha, Walker, Bruce D, Chakraborty, Arup, Ndung'u, Thumbi

“…Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational…”
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The evaluation of lumbar multifidus muscle function via palpation: reliability and validity of a new clinical test by Hebert, Jeffrey J., DC, PhD, Koppenhaver, Shane L., PhD, PT, Teyhen, Deydre S., PhD, PT, Walker, Bruce F., DC, MPH, DrPH, Fritz, Julie M., PhD, PT

“…Abstract Background context The lumbar multifidus muscle provides an important contribution to lumbar spine stability, and the restoration of lumbar multifidus…”
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Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes by Jones, Richard Brad, O'Connor, Rachel, Mueller, Stefanie, Foley, Maria, Szeto, Gregory L, Karel, Dan, Lichterfeld, Mathias, Kovacs, Colin, Ostrowski, Mario A, Trocha, Alicja, Irvine, Darrell J, Walker, Bruce D

“…Resting memory CD4+ T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as…”
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Human Immunodeficiency Virus Controllers: Mechanisms of Durable Virus Control in the Absence of Antiretroviral Therapy by Deeks, Steven G., Walker, Bruce D.

“…Chronic viral infections can appear in two very different forms: those that are typically immunologically contained after acute symptomatic infection, such as…”
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Evolution and Diversity of Immune Responses during Acute HIV Infection by Kazer, Samuel W., Walker, Bruce D., Shalek, Alex K.

“…Understanding the earliest immune responses following HIV infection is critical to inform future vaccines and therapeutics. Here, we review recent prospective…”
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Toward an AIDS Vaccine by Walker, Bruce D, Burton, Dennis R

“…A quarter century of scientific discovery has been applied to developing an AIDS vaccine, yet this goal remains elusive. Specific characteristics of the virus,…”
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T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals by Naranbhai, Vivek, Nathan, Anusha, Kaseke, Clarety, Berrios, Cristhian, Khatri, Ashok, Choi, Shawn, Getz, Matthew A., Tano-Menka, Rhoda, Ofoman, Onosereme, Gayton, Alton, Senjobe, Fernando, Zhao, Zezhou, St Denis, Kerri J., Lam, Evan C., Carrington, Mary, Garcia-Beltran, Wilfredo F., Balazs, Alejandro B., Walker, Bruce D., Iafrate, A. John, Gaiha, Gaurav D.

“…The SARS-CoV-2 Omicron variant (B.1.1.529) contains mutations that mediate escape from antibody responses, although the extent to which these substitutions in…”
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Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination by Mahan, Alison E, Jennewein, Madeleine F, Suscovich, Todd, Dionne, Kendall, Tedesco, Jacquelynne, Chung, Amy W, Streeck, Hendrik, Pau, Maria, Schuitemaker, Hanneke, Francis, Don, Fast, Patricia, Laufer, Dagna, Walker, Bruce D, Baden, Lindsey, Barouch, Dan H, Alter, Galit

“…Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role…”
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Resistance of HIV-infected macrophages to CD8+ T lymphocyte–mediated killing drives activation of the immune system by Clayton, Kiera L., Collins, David R., Lengieza, Josh, Ghebremichael, Musie, Dotiwala, Farokh, Lieberman, Judy, Walker, Bruce D.

“…CD4 + T lymphocytes are the principal target of human immunodeficiency virus (HIV), but infected macrophages also contribute to viral pathogenesis. The killing…”
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Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal by Cohen, Keira A, Abeel, Thomas, Manson McGuire, Abigail, Desjardins, Christopher A, Munsamy, Vanisha, Shea, Terrance P, Walker, Bruce J, Bantubani, Nonkqubela, Almeida, Deepak V, Alvarado, Lucia, Chapman, Sinéad B, Mvelase, Nomonde R, Duffy, Eamon Y, Fitzgerald, Michael G, Govender, Pamla, Gujja, Sharvari, Hamilton, Susanna, Howarth, Clinton, Larimer, Jeffrey D, Maharaj, Kashmeel, Pearson, Matthew D, Priest, Margaret E, Zeng, Qiandong, Padayatchi, Nesri, Grosset, Jacques, Young, Sarah K, Wortman, Jennifer, Mlisana, Koleka P, O'Donnell, Max R, Birren, Bruce W, Bishai, William R, Pym, Alexander S, Earl, Ashlee M

“…The continued advance of antibiotic resistance threatens the treatment and control of many infectious diseases. This is exemplified by the largest global…”
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