Search Results - "Walker, Benjimen R"

Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels by Naik, Jay S, Osmond, Jessica M, Walker, Benjimen R, Kanagy, Nancy L

“…Hydrogen sulfide (H S) is a recently described gaseous vasodilator produced within the vasculature by the enzymes cystathionine γ-lyase and 3-mercaptopyruvate…”
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Endothelial-dependent dilation following chronic hypoxia involves TRPV4-mediated activation of endothelial BK channels by Naik, Jay S., Walker, Benjimen R.

“…Following chronic hypoxia (CH), the systemic vasculature exhibits blunted vasoconstriction due to endothelial-dependent hyperpolarization (EDH). Previous data…”
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Augmented Pulmonary Vasoconstrictor Reactivity after Chronic Hypoxia Requires Src Kinase and Epidermal Growth Factor Receptor Signaling by Norton, Charles E, Sheak, Joshua R, Yan, Simin, Weise-Cross, Laura, Jernigan, Nikki L, Walker, Benjimen R, Resta, Thomas C

“…Chronic hypoxia augments pressure- and agonist-induced pulmonary vasoconstriction through myofilament calcium sensitization. NADPH oxidases contribute to the…”
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Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia by Jernigan, Nikki L, Walker, Benjimen R, Resta, Thomas C

“…Recent evidence supports a prominent role for Rho kinase (ROK)-mediated pulmonary vasoconstriction in the development and maintenance of chronic hypoxia…”
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Coupling of store-operated calcium entry to vasoconstriction is acid-sensing ion channel 1a dependent in pulmonary but not mesenteric arteries by Garcia, Selina M, Herbert, Lindsay M, Walker, Benjimen R, Resta, Thomas C, Jernigan, Nikki L

“…Although voltage-gated Ca2+ channels (VGCC) are a major Ca2+ entry pathway in vascular smooth muscle cells (VSMCs), several other Ca2+-influx mechanisms exist…”
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Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses by Detweiler, Neil D, Vigil, Kenneth G, Resta, Thomas C, Walker, Benjimen R, Jernigan, Nikki L

“…Previous reports indicate roles for acid-sensing ion channels (ASICs) in both peripheral and central chemoreception, but the contributions of ASICs to…”
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Intermittent Hypoxia in Rats Increases Myogenic Tone Through Loss of Hydrogen Sulfide Activation of Large-Conductance Ca2+-Activated Potassium Channels by Jackson-Weaver, Olan, Paredes, Daniel A, Bosc, Laura V Gonzalez, Walker, Benjimen R, Kanagy, Nancy L

“…RATIONALE:Myogenic tone, an important regulator of vascular resistance, is dependent on vascular smooth muscle (VSM) depolarization, can be modulated by…”
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Contribution of Mitochondrial Reactive Oxygen Species to Chronic Hypoxia-Induced Pulmonary Hypertension by Yan, Simin, Sheak, Joshua R, Walker, Benjimen R, Jernigan, Nikki L, Resta, Thomas C

“…Pulmonary hypertension (PH) resulting from chronic hypoxia (CH) occurs in patients with chronic obstructive pulmonary diseases, sleep apnea, and restrictive…”
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Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension by Nitta, Carlos H, Osmond, David A, Herbert, Lindsay M, Beasley, Britta F, Resta, Thomas C, Walker, Benjimen R, Jernigan, Nikki L

“…Chronic hypoxia (CH) associated with respiratory disease results in elevated pulmonary vascular intracellular Ca(2+) concentration, which elicits enhanced…”
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Short-term high fat diet alters genes associated with metabolic and vascular dysfunction during adolescence in rats: a pilot study by Mohr, Alex E, Reiss, Rebecca A, Beaudet, Monique, Sena, Johnny, Naik, Jay S, Walker, Benjimen R, Sweazea, Karen L

“…Background Diet-induced metabolic dysfunction precedes multiple disease states including diabetes, heart disease, and vascular dysfunction. The critical role…”
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Augmented Endothelin Vasoconstriction in Intermittent Hypoxia-Induced Hypertension by Allahdadi, Kyan J, Walker, Benjimen R, Kanagy, Nancy L

“…We reported previously that simulating sleep apnea in rats by exposing them 7 hours per day to intermittent hypoxia/hypercapnia (IH) elevates plasma…”
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Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA by Broughton, Brad R S, Jernigan, Nikki L, Norton, Charles E, Walker, Benjimen R, Resta, Thomas C

“…Rho kinase (ROCK)-dependent vasoconstriction has been implicated as a major factor in chronic hypoxia (CH)-induced pulmonary hypertension. This component of…”
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Membrane depolarization is required for pressure-dependent pulmonary arterial tone but not enhanced vasoconstriction to endothelin-1 following chronic hypoxia by Norton, Charles E, Jernigan, Nikki L, Walker, Benjimen R, Resta, Thomas C

“…Enhanced vasoconstriction is increasingly identified as an important contributor to the development of pulmonary hypertension. Chronic hypoxia results in…”
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Comparison of mechanisms involved in impaired vascular reactivity between high sucrose and high fat diets in rats by Sweazea, Karen L, Lekic, Mateja, Walker, Benjimen R

“…To determine the effects of high sucrose diets on vascular reactivity. We hypothesized that similar to high fat diets (HFD), HSD feeding would lead to…”
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Differential effects of chronic hypoxia and intermittent hypocapnic and eucapnic hypoxia on pulmonary vasoreactivity by Snow, Jessica B, Kitzis, Vanessa, Norton, Charles E, Torres, Samantha N, Johnson, Kimberly D, Kanagy, Nancy L, Walker, Benjimen R, Resta, Thomas C

“…Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico Submitted 13…”
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Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia by Earley, Scott, Pastuszyn, Andrzej, Walker, Benjimen R

“…The systemic vasculature exhibits attenuated vasoconstriction following chronic hypoxia (CH) that is associated with endothelium-dependent vascular smooth…”
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Role of Endothelin in Intermittent Hypoxia-Induced Hypertension by Kanagy, Nancy L, Walker, Benjimen R, Nelin, Leif D

“…Clinical studies suggest that sleep apnea causes systemic hypertension. In addition, patients with sleep apnea have elevated plasma levels of endothelin-1…”
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Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries by Earley, Scott, Resta, Thomas C, Walker, Benjimen R

“…Communication between vascular smooth muscle (VSM) cells via low-resistance gap junctions may facilitate vascular function by synchronizing the contractile…”
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Impaired myogenic tone in mesenteric arteries from overweight rats by Sweazea, Karen L, Walker, Benjimen R

“…Rats fed high fat (HFD) or high sucrose (HSD) diets develop increased adiposity as well as impaired vasodilatory responsiveness stemming from oxidative stress…”
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EC Membrane Cholesterol Content Regulates the Contribution of TRPV4 Channels in ACh‐induced vasodilation in Rat Gracilis Arteries by Salbato, Sophia, Morin, Emily E., Walker, Benjimen R., Naik, Jay S.

“…Numerous studies show that ion channel activity is sensitive to the level of membrane cholesterol, with cholesterol most often suppressing channel activity…”
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