Search Results - "Walker, Amy K"

WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data by Holdorf, Amy D, Higgins, Daniel P, Hart, Anne C, Boag, Peter R, Pazour, Gregory J, Walhout, Albertha J M, Walker, Amy K

“…Abstract The emergence of large gene expression datasets has revealed the need for improved tools to identify enriched gene categories and visualize enrichment…”
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A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans by Walker, Amy K., Jacobs, René L., Watts, Jennifer L., Rottiers, Veerle, Jiang, Karen, Finnegan, Deirdre M., Shioda, Toshi, Hansen, Malene, Yang, Fajun, Niebergall, Lorissa J., Vance, Dennis E., Tzoneva, Monika, Hart, Anne C., Näär, Anders M.

“…Sterol regulatory element-binding proteins (SREBPs) activate genes involved in the synthesis and trafficking of cholesterol and other lipids and are critical…”
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s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways by Ding, Wei, Smulan, Lorissa J., Hou, Nicole S., Taubert, Stefan, Watts, Jennifer L., Walker, Amy K.

“…s-adenosylmethionine (SAM) is the sole methyl donor modifying histones, nucleic acids, and phospholipids. Its fluctuation affects hepatic phosphatidylcholine…”
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Germ Cells Need Folate to Proliferate by Walker, Amy K.

“…In this issue of Developmental Cell, Chaudhari and colleagues (2016) use a novel method to create an in vitro proliferative cell line from tumorous C. elegans…”
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The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling by Alexander, Kellianne D., Ramachandran, Shankar, Biswas, Kasturi, Lambert, Christopher M., Russell, Julia, Oliver, Devyn B., Armstrong, William, Rettler, Monika, Liu, Samuel, Doitsidou, Maria, Bénard, Claire, Walker, Amy K., Francis, Michael M.

“…The elimination of synapses during circuit remodeling is critical for brain maturation; however, the molecular mechanisms directing synapse elimination and its…”
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Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine by Ding, Wei, Higgins, Daniel P, Yadav, Dilip K, Godbole, Adwait A, Pukkila-Worley, Read, Walker, Amy K

“…S-adenosylmethionine (SAM) is a donor which provides the methyl groups for histone or nucleic acid modification and phosphatidylcholine production. SAM is…”
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Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation by Smulan, Lorissa J., Ding, Wei, Freinkman, Elizaveta, Gujja, Sharvari, Edwards, Yvonne J.K., Walker, Amy K.

“…Lipogenesis requires coordinated expression of genes for fatty acid, phospholipid, and triglyceride synthesis. Transcription factors, such as SREBP-1 (Sterol…”
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S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress by Godbole, Adwait A, Gopalan, Sneha, Nguyen, Thien-Kim, Munden, Alexander L, Lui, Dominique S, Fanelli, Matthew J, Vo, Paula, Lewis, Caroline A, Spinelli, Jessica B, Fazzio, Thomas G, Walker, Amy K

“…Methylation is a widely occurring modification that requires the methyl donor S-adenosylmethionine (SAM) and acts in regulation of gene expression and other…”
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An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis by Näär, Anders M, Yang, Fajun, Vought, Bryan W, Satterlee, John S, Walker, Amy K, Jim Sun, Z.-Y, Watts, Jennifer L, DeBeaumont, Rosalie, Mako Saito, R, Hyberts, Sven G, Yang, Shaosong, Macol, Christine, Iyer, Lakshmanan, Tjian, Robert, van den Heuvel, Sander, Hart, Anne C, Wagner, Gerhard

“…The sterol regulatory element binding protein (SREBP) family of transcription activators are critical regulators of cholesterol and fatty acid homeostasis. We…”
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Defining characteristics and conservation of poorly annotated genes in Caenorhabditis elegans using WormCat 2.0 by Higgins, Daniel P, Weisman, Caroline M, Lui, Dominique S, D’Agostino, Frank A, Walker, Amy K

“…Abstract Omics tools provide broad datasets for biological discovery. However, the computational tools for identifying important genes or pathways in RNA-seq,…”
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Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP by Walker, Amy K, Yang, Fajun, Jiang, Karen, Ji, Jun-Yuan, Watts, Jennifer L, Purushotham, Aparna, Boss, Olivier, Hirsch, Michael L, Ribich, Scott, Smith, Jesse J, Israelian, Kristine, Westphal, Christoph H, Rodgers, Joseph T, Shioda, Toshi, Elson, Sarah L, Mulligan, Peter, Najafi-Shoushtari, Hani, Black, Josh C, Thakur, Jitendra K, Kadyk, Lisa C, Whetstine, Johnathan R, Mostoslavsky, Raul, Puigserver, Pere, Li, Xiaoling, Dyson, Nicholas J, Hart, Anne C, Näär, Anders M

“…The sterol regulatory element-binding protein (SREBP) transcription factor family is a critical regulator of lipid and sterol homeostasis in eukaryotes. In…”
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Immunity-linked genes are stimulated by a membrane stress pathway linked to Golgi function and the ARF-1 GTPase by Fanelli, Matthew J, Welsh, Christofer M, Lui, Dominique S, Smulan, Lorissa J, Walker, Amy K

“…Infection response and other immunity-linked genes (ILGs) were first named in -based expression after pathogen challenge, but many are also up-regulated when…”
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An Extensive Requirement for Transcription Factor IID-specific TAF-1 in Caenorhabditis elegans Embryonic Transcription by Walker, Amy K., Shi, Yang, Blackwell, T. Keith

“…The general transcription factor TFIID sets the mRNA start site and consists of TATA-binding protein and associated factors (TAFIIs), some of which are also…”
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CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo by Shim, Eun Yong, Walker, Amy K, Shi, Yang, Blackwell, T Keith

“…The metazoan transcription elongation factor P-TEFb (CDK-9/cyclin T) is essential for HIV transcription, and is recruited by some cellular activators. P-TEFb…”
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Broad Requirement for the Mediator Subunit RGR-1 for Transcription in the Caenorhabditis elegans Embryo by Shim, Eun Yong, Walker, Amy K, Blackwell, T Keith

“…The Mediator-related transcription co-factors integrate positive and negative inputs and recruit and activate the RNA polymerase II complex. To understand the…”
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Transcription reactivation steps stimulated by oocyte maturation in C. elegans by Walker, Amy K., Boag, Peter R., Blackwell, T. Keith

“…Developing oocytes produce materials that will support early embryonic development then cease transcription before fertilization. Later, a distinct…”
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OMA-Gosh, Where's that TAF? by Blackwell, T. Keith, Walker, Amy K.

“…How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during…”
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Distinct requirements for C.elegans TAFIIs in early embryonic transcription by Walker, Amy K., Rothman, Joel H., Shi, Yang, Blackwell, T.Keith

“…TAFIIs are conserved components of the TFIID, TFTC and SAGA‐related mRNA transcription complexes. In yeast (y), yTAFII17 is required broadly for transcription,…”
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A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans by Walker, Amy K, Blackwell, T Keith

“…As conserved components of the transcription factor (TF) IID- and TFTC/SAGA-related complexes, TATA-binding protein-associated factors (TAF(II)s) are important…”
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A Conserved Transcription Motif Suggesting Functional Parallels between Caenorhabditis elegans SKN-1 and Cap'n'Collar-related Basic Leucine Zipper Proteins by Walker, Amy K., See, Raymond, Batchelder, Ceri, Kophengnavong, Thip, Gronniger, J.Timothy, Shi, Yang, Blackwell, T.Keith

“…In Caenorhabditis elegans, the predicted transcription factor SKN-1 is required for embryonic endodermal and mesodermal specification and for maintaining…”
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