Search Results - "Walker, Alex J."

Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February by Grint, Daniel J, Wing, Kevin, Williamson, Elizabeth, McDonald, Helen I, Bhaskaran, Krishnan, Evans, David, Evans, Stephen Jw, Walker, Alex J, Hickman, George, Nightingale, Emily, Schultze, Anna, Rentsch, Christopher T, Bates, Chris, Cockburn, Jonathan, Curtis, Helen J, Morton, Caroline E, Bacon, Sebastian, Davy, Simon, Wong, Angel Ys, Mehrkar, Amir, Tomlinson, Laurie, Douglas, Ian J, Mathur, Rohini, Blomquist, Paula, MacKenna, Brian, Ingelsby, Peter, Croker, Richard, Parry, John, Hester, Frank, Harper, Sam, DeVito, Nicholas J, Hulme, Will, Tazare, John, Goldacre, Ben, Smeeth, Liam, Eggo, Rosalind M

“…The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is…”
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Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England by Grint, Daniel J, Wing, Kevin, Houlihan, Catherine, Gibbs, Hamish P, Evans, Stephen J W, Williamson, Elizabeth, McDonald, Helen I, Bhaskaran, Krishnan, Evans, David, Walker, Alex J, Hickman, George, Nightingale, Emily, Schultze, Anna, Rentsch, Christopher T, Bates, Chris, Cockburn, Jonathan, Curtis, Helen J, Morton, Caroline E, Bacon, Sebastian, Davy, Simon, Wong, Angel Y S, Mehrkar, Amir, Tomlinson, Laurie, Douglas, Ian J, Mathur, Rohini, MacKenna, Brian, Ingelsby, Peter, Croker, Richard, Parry, John, Hester, Frank, Harper, Sam, DeVito, Nicholas J, Hulme, Will, Tazare, John, Smeeth, Liam, Goldacre, Ben, Eggo, Rosalind M

“…Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) alpha variant (B.1.1.7) is associated with higher transmissibility than…”
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Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform by Bhaskaran, Krishnan, Rentsch, Christopher T, Hickman, George, Hulme, William J, Schultze, Anna, Curtis, Helen J, Wing, Kevin, Warren-Gash, Charlotte, Tomlinson, Laurie, Bates, Chris J, Mathur, Rohini, MacKenna, Brian, Mahalingasivam, Viyaasan, Wong, Angel, Walker, Alex J, Morton, Caroline E, Grint, Daniel, Mehrkar, Amir, Eggo, Rosalind M, Inglesby, Peter, Douglas, Ian J, McDonald, Helen I, Cockburn, Jonathan, Williamson, Elizabeth J, Evans, David, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen Jw, Bacon, Sebastian, Smeeth, Liam, Goldacre, Ben

“…There is concern about medium to long-term adverse outcomes following acute Coronavirus Disease 2019 (COVID-19), but little relevant evidence exists. We aimed…”
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Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform by Bhaskaran, Krishnan, Bacon, Sebastian, Evans, Stephen JW, Bates, Chris J, Rentsch, Christopher T, MacKenna, Brian, Tomlinson, Laurie, Walker, Alex J, Schultze, Anna, Morton, Caroline E, Grint, Daniel, Mehrkar, Amir, Eggo, Rosalind M, Inglesby, Peter, Douglas, Ian J, McDonald, Helen I, Cockburn, Jonathan, Williamson, Elizabeth J, Evans, David, Curtis, Helen J, Hulme, William J, Parry, John, Hester, Frank, Harper, Sam, Spiegelhalter, David, Smeeth, Liam, Goldacre, Ben

“…Mortality from COVID-19 shows a strong relationship with age and pre-existing medical conditions, as does mortality from other causes. We aimed to investigate…”
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Challenges in Estimating the Effectiveness of COVID-19 Vaccination Using Observational Data by Hulme, William J, Williamson, Elizabeth, Horne, Elsie M F, Green, Amelia, McDonald, Helen I, Walker, Alex J, Curtis, Helen J, Morton, Caroline E, MacKenna, Brian, Croker, Richard, Mehrkar, Amir, Bacon, Seb, Evans, David, Inglesby, Peter, Davy, Simon, Bhaskaran, Krishnan, Schultze, Anna, Rentsch, Christopher T, Tomlinson, Laurie, Douglas, Ian J, Evans, Stephen J W, Smeeth, Liam, Palmer, Tom, Goldacre, Ben, Hernán, Miguel A, Sterne, Jonathan A C

“…The COVID-19 vaccines were developed and rigorously evaluated in randomized trials during 2020. However, important questions, such as the magnitude and…”
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Prescription of suboptimal statin treatment regimens: a retrospective cohort study of trends and variation in English primary care by Curtis, Helen J, Walker, Alex J, MacKenna, Brian, Croker, Richard, Goldacre, Ben

“…Background Since 2014 English national guidance recommends ‘high-intensity’ statins, reducing low-density lipoprotein (LDL) cholesterol by ≥40%. Aim To…”
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Trends and variation in antidepressant prescribing in English primary care: a retrospective longitudinal study by Bogowicz, Paul, Curtis, Helen J, Walker, Alex J, Cowen, Philip, Geddes, John, Goldacre, Ben

“…Background Antidepressants are commonly prescribed. There are clear national guidelines in relation to treatment sequencing. This study examines trends and…”
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Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis by Khan, Umair T, Walker, Alex J, Baig, Sadaf, Card, Tim R, Kirwan, Cliona C, Grainge, Matthew J

“…Breast cancer patients are at an increased risk of venous thromboembolism (VTE). However, current evidence as to whether VTE increases the risk of mortality in…”
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Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients' records at source using OpenSAFELY by Andrews, Colm D, Mathur, Rohini, Massey, Jon, Park, Robin, Curtis, Helen J, Hopcroft, Lisa, Mehrkar, Amir, Bacon, Seb, Hickman, George, Smith, Rebecca, Evans, David, Ward, Tom, Davy, Simon, Inglesby, Peter, Dillingham, Iain, Maude, Steven, O'Dwyer, Thomas, Butler-Cole, Ben F C, Bridges, Lucy, Bates, Chris, Parry, John, Hester, Frank, Harper, Sam, Cockburn, Jonathan, Goldacre, Ben, MacKenna, Brian, Tomlinson, Laurie A, Walker, Alex J, Hulme, William J

“…Ethnicity is known to be an important correlate of health outcomes, particularly during the COVID-19 pandemic, where some ethnic groups were shown to be at…”
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Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study by Henry, Mei-Ling, Abdul-Sultan, Alyshah, Walker, Alex J, West, Joe, Humes, David J

“…This study aimed to identify the burden and risk of venous thromboembolism (VTE) associated with cholecystectomy in England. An historical cohort study of…”
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Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP by Lemanska, Agnieszka, Andrews, Colm, Fisher, Louis, Bacon, Seb, Frampton, Adam E, Mehrkar, Amir, Inglesby, Peter, Davy, Simon, Roberts, Keith, Patalay, Praveetha, Goldacre, Ben, MacKenna, Brian, Walker, Alex J

“…Healthcare across all sectors, in the UK and globally, was negatively affected by the COVID-19 pandemic. We analysed healthcare services delivered to people…”
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Detecting change in comparison to peers in NHS prescribing data: a novel application of cumulative sum methodology by Walker, Alex J, Bacon, Seb, Croker, Richard, Goldacre, Ben

“…The widely used OpenPrescribing.net service provides standard measures which compare prescribing of Clinical Commissioning Groups (CCGs) and English General…”
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Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants: population-based cohort study by Wong, Angel Y S, Tomlinson, Laurie A, Brown, Jeremy P, Elson, William, Walker, Alex J, Schultze, Anna, Morton, Caroline E, Evans, David, Inglesby, Peter, MacKenna, Brian, Bhaskaran, Krishnan, Rentsch, Christopher T, Powell, Emma, Williamson, Elizabeth, Croker, Richard, Bacon, Seb, Hulme, William, Bates, Chris, Curtis, Helen J, Mehrkar, Amir, Cockburn, Jonathan, McDonald, Helen I, Mathur, Rohini, Wing, Kevin, Forbes, Harriet, Eggo, Rosalind M, Evans, Stephen J W, Smeeth, Liam, Goldacre, Ben, Douglas, Ian J

“…Thromboembolism has been reported as a consequence of severe COVID-19. Although warfarin is a commonly used anticoagulant, it acts by antagonising vitamin K,…”
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Risk of venous thromboembolism in hospitalised cancer patients in England-a cohort study by Ratib, Sonia, Walker, Alex J, Card, Tim R, Grainge, Matthew J

“…Venous thromboembolism (VTE) is a well-recognised and life-threatening complication in patients with cancer. However, the precise risk of VTE in hospitalised…”
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Factors associated with COVID-19 vaccine uptake in people with kidney disease: an OpenSAFELY cohort study by Parker, Edward PK, Tazare, John, Hulme, William J, Bates, Christopher, Carr, Edward J, Cockburn, Jonathan, Curtis, Helen J, Fisher, Louis, Green, Amelia CA, Harper, Sam, Hester, Frank, Horne, Elsie MF, Loud, Fiona, Lyon, Susan, Mahalingasivam, Viyaasan, Mehrkar, Amir, Nab, Linda, Parry, John, Santhakumaran, Shalini, Steenkamp, Retha, Sterne, Jonathan AC, Walker, Alex J, Williamson, Elizabeth J, Willicombe, Michelle, Zheng, Bang, Goldacre, Ben, Nitsch, Dorothea, Tomlinson, Laurie A

“…ObjectiveTo characterise factors associated with COVID-19 vaccine uptake among people with kidney disease in England.DesignRetrospective cohort study using the…”
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OpenSAFELY: impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic by Curtis, Helen J, MacKenna, Brian, Walker, Alex J, Croker, Richard, Mehrkar, Amir, Morton, Caroline, Bacon, Seb, Hickman, George, Inglesby, Peter, Bates, Chris, Evans, David, Ward, Tom, Cockburn, Jonathan, Davy, Simon, Bhaskaran, Krishnan, Schultze, Anna, Rentsch, Christopher T, Williamson, Elizabeth, Hulme, William, Tomlinson, Laurie, Mathur, Rohini, Drysdale, Henry, Eggo, Rosalind M, Wong, Angel Yun, Forbes, Harriet, Parry, John, Hester, Frank, Harper, Sam, Douglas, Ian, Smeeth, Liam, Goldacre, Ben

“…BackgroundEarly in the COVID-19 pandemic, the National Health Service (NHS) recommended that appropriate patients anticoagulated with warfarin should be…”
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Impact of COVID-19 on recorded blood pressure screening and hypertension management in England: an analysis of monthly changes in the quality and outcomes framework indicators in OpenSAFELY by Wiedemann, Milan, Speed, Victoria, Cunningham, Christine, Higgins, Rose, Curtis, Helen J, Andrews, Colm, Fisher, Louis, Hopcroft, Lisa, Rentsch, Christopher T, Mahalingasivam, Viyaasan, Tomlinson, Laurie, Morton, Caroline, Samuel, Miriam, Green, Amelia, Wood, Christopher, Brown, Andrew D, Massey, Jon, Walters, Caroline, Smith, Rebecca M, Inglesby, Peter, Evans, David, Maude, Steven, Dillingham, Iain, Walker, Alex J, Morley, Jessica, Mehrkar, Amir, Bacon, Seb, Bates, Chris, Cockburn, Jonathan, Parry, John, Hester, Frank, McManus, Richard J, Goldacre, Ben, MacKenna, Brian

“…BackgroundThe COVID-19 pandemic disrupted cardiovascular disease management in primary care in England.ObjectiveTo describe the impact of the pandemic on blood…”
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Studying the Long-term Impact of COVID-19 in Kids (SLICK). Healthcare use and costs in children and young people following community-acquired SARS-CoV-2 infection: protocol for an observational study using linked primary and secondary routinely collected healthcare data from England, Scotland and Wales by Swann, Olivia V, Lone, Nazir I, Harrison, Ewen M, Tomlinson, Laurie A, Walker, Alex J, Seaborne, Michael J, Pollock, Louisa, Farrell, James, Hall, Peter S, Seth, Sohan, Williams, Thomas C, Preston, Jennifer, Ainsworth, J. Samantha, Semple, Freya F, Baillie, J Kenneth, Katikireddi, Srinivasa V, Akbari, Ashley, Lyons, Ronan, Simpson, Colin R, Semple, Malcolm G, Goldacre, Ben, Brophy, Sinead, Sheikh, Aziz, Docherty, Annemarie B

“…IntroductionSARS-CoV-2 infection rarely causes hospitalisation in children and young people (CYP), but mild or asymptomatic infections are common. Persistent…”
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Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England by Hopcroft, Lisa Em, Massey, Jon, Curtis, Helen J, Mackenna, Brian, Croker, Richard, Brown, Andrew D, O'Dwyer, Thomas, Macdonald, Orla, Evans, David, Inglesby, Peter, Bacon, Sebastian Cj, Goldacre, Ben, Walker, Alex J

“…Approaches to addressing unwarranted variation in health care service delivery have traditionally relied on the prospective identification of activities and…”
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Factors associated with COVID-19-related death using OpenSAFELY by Williamson, Elizabeth J., Walker, Alex J., Bhaskaran, Krishnan, Bacon, Seb, Bates, Chris, Morton, Caroline E., Curtis, Helen J., Mehrkar, Amir, Evans, David, Inglesby, Peter, Cockburn, Jonathan, McDonald, Helen I., MacKenna, Brian, Tomlinson, Laurie, Douglas, Ian J., Rentsch, Christopher T., Mathur, Rohini, Wong, Angel Y. S., Grieve, Richard, Harrison, David, Forbes, Harriet, Schultze, Anna, Croker, Richard, Parry, John, Hester, Frank, Harper, Sam, Perera, Rafael, Evans, Stephen J. W., Smeeth, Liam, Goldacre, Ben

“…Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide 1 . There is unprecedented urgency to understand who is most at risk of severe…”
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