Search Results - "Walker, Alan"

Human microbiome myths and misconceptions by Walker, Alan W., Hoyles, Lesley

“…Over the past two decades, interest in human microbiome research has increased exponentially. Regrettably, this increased activity has brought with it a degree…”
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Shotgun metagenomics, from sampling to analysis by Quince, Christopher, Walker, Alan W, Simpson, Jared T, Loman, Nicholas J, Segata, Nicola

“…The promises and potential pitfalls of shotgun metagenomics, from experimental design to computational analyses, are reviewed. Diverse microbial communities of…”
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Intestinal colonization resistance by Lawley, Trevor D., Walker, Alan W.

“…Summary Dense, complex microbial communities, collectively termed the microbiota, occupy a diverse array of niches along the length of the mammalian intestinal…”
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Compendium of 4,941 rumen metagenome-assembled genomes for rumen microbiome biology and enzyme discovery by Stewart, Robert D., Auffret, Marc D., Warr, Amanda, Walker, Alan W., Roehe, Rainer, Watson, Mick

“…Ruminants provide essential nutrition for billions of people worldwide. The rumen is a specialized stomach that is adapted to the breakdown of plant-derived…”
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High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease by Walker, Alan W, Sanderson, Jeremy D, Churcher, Carol, Parkes, Gareth C, Hudspith, Barry N, Rayment, Neil, Brostoff, Jonathan, Parkhill, Julian, Dougan, Gordon, Petrovska, Liljana

“…The gut microbiota is thought to play a key role in the development of the inflammatory bowel diseases Crohn's disease (CD) and ulcerative colitis (UC). Shifts…”
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The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation by Zaiss, Mario M., Rapin, Alexis, Lebon, Luc, Dubey, Lalit Kumar, Mosconi, Ilaria, Sarter, Kerstin, Piersigilli, Alessandra, Menin, Laure, Walker, Alan W., Rougemont, Jacques, Paerewijck, Oonagh, Geldhof, Peter, McCoy, Kathleen D., Macpherson, Andrew J., Croese, John, Giacomin, Paul R., Loukas, Alex, Junt, Tobias, Marsland, Benjamin J., Harris, Nicola L.

“…Intestinal helminths are potent regulators of their host’s immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study…”
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The impact of different DNA extraction kits and laboratories upon the assessment of human gut microbiota composition by 16S rRNA gene sequencing by Kennedy, Nicholas A, Walker, Alan W, Berry, Susan H, Duncan, Sylvia H, Farquarson, Freda M, Louis, Petra, Thomson, John M, Satsangi, Jack, Flint, Harry J, Parkhill, Julian, Lees, Charlie W, Hold, Georgina L

“…Determining bacterial community structure in fecal samples through DNA sequencing is an important facet of intestinal health research. The impact of different…”
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Ticks of Australia. The species that infest domestic animals and humans by Barker, Stephen C, Walker, Alan R

“…The book Australian Ticks by F.H.S. Roberts (1970) is a land-mark in Australian tick biology. But it is time for a new and improved book on the ticks of…”
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The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives by d'Enfert, Christophe, Kaune, Ann-Kristin, Alaban, Leovigildo-Rey, Chakraborty, Sayoni, Cole, Nathaniel, Delavy, Margot, Kosmala, Daria, Marsaux, Benoît, Fróis-Martins, Ricardo, Morelli, Moran, Rosati, Diletta, Valentine, Marisa, Xie, Zixuan, Emritloll, Yoan, Warn, Peter A, Bequet, Frédéric, Bougnoux, Marie-Elisabeth, Bornes, Stephanie, Gresnigt, Mark S, Hube, Bernhard, Jacobsen, Ilse D, Legrand, Mélanie, Leibundgut-Landmann, Salomé, Manichanh, Chaysavanh, Munro, Carol A, Netea, Mihai G, Queiroz, Karla, Roget, Karine, Thomas, Vincent, Thoral, Claudia, Van den Abbeele, Pieter, Walker, Alan W, Brown, Alistair J P

“…ABSTRACT Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral cavity, gut or genital tract of most individuals,…”
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The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells by Powell, Nick, Walker, Alan W., Stolarczyk, Emilie, Canavan, James B., Gökmen, M. Refik, Marks, Ellen, Jackson, Ian, Hashim, Ahmed, Curtis, Michael A., Jenner, Richard G., Howard, Jane K., Parkhill, Julian, MacDonald, Thomas T., Lord, Graham M.

“…Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent colitis. Here, we show that interleukin-17A…”
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Assembly of 913 microbial genomes from metagenomic sequencing of the cow rumen by Stewart, Robert D., Auffret, Marc D., Warr, Amanda, Wiser, Andrew H., Press, Maximilian O., Langford, Kyle W., Liachko, Ivan, Snelling, Timothy J., Dewhurst, Richard J., Walker, Alan W., Roehe, Rainer, Watson, Mick

“…The cow rumen is adapted for the breakdown of plant material into energy and nutrients, a task largely performed by enzymes encoded by the rumen microbiome…”
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Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in Mice by Dalby, Matthew J., Ross, Alexander W., Walker, Alan W., Morgan, Peter J.

“…Evidence suggests that altered gut microbiota composition may be involved in the development of obesity. Studies using mice made obese with refined high-fat…”
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Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice by Lawley, Trevor D, Clare, Simon, Walker, Alan W, Stares, Mark D, Connor, Thomas R, Raisen, Claire, Goulding, David, Rad, Roland, Schreiber, Fernanda, Brandt, Cordelia, Deakin, Laura J, Pickard, Derek J, Duncan, Sylvia H, Flint, Harry J, Clark, Taane G, Parkhill, Julian, Dougan, Gordon

“…Relapsing C. difficile disease in humans is linked to a pathological imbalance within the intestinal microbiota, termed dysbiosis, which remains poorly…”
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Patent human infections with the whipworm, Trichuris trichiura, are not associated with alterations in the faecal microbiota by Cooper, Philip, Walker, Alan W, Reyes, Jorge, Chico, Martha, Salter, Susannah J, Vaca, Maritza, Parkhill, Julian

“…The soil-transmitted helminth (STH), Trichuris trichiura colonises the human large intestine where it may modify inflammatory responses, an effect possibly…”
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Bacterial microbiota of the upper respiratory tract and childhood asthma by Depner, Martin, PhD, Ege, Markus J., MD, Cox, Michael J., PhD, Dwyer, Sarah, PhD, Walker, Alan W., PhD, Birzele, Lena T, Genuneit, Jon, MD, Horak, Elisabeth, MD, Braun-Fahrländer, Charlotte, MD, Danielewicz, Hanna, MD, PhD, Maier, Raina M., PhD, Moffatt, Miriam F., PhD, Cookson, William O., MD, Heederik, Dick, PhD, von Mutius, Erika, MD, Legatzki, Antje, PhD

“…Background Patients with asthma and healthy controls differ in bacterial colonization of the respiratory tract. The upper airways have been shown to reflect…”
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Fighting Obesity with Bacteria by Walker, Alan W., Parkhill, Julian

“…Intestinal bacteria from lean humans can confer protection against fat gain in experimental mice. [Also see Research Article by Ridaura et al. ] The human…”
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The New Ageism by WALKER, ALAN

“…This article takes issue with the apparently entrenched political narrative about ageing and older people which is routinely expressed in both ministerial…”
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Phylogeny, culturing, and metagenomics of the human gut microbiota by Walker, Alan W, Duncan, Sylvia H, Louis, Petra, Flint, Harry J

“…Highlights • Metagenomics has revolutionised research into human intestinal microbes. • Limitations of metagenomics mean that culturing and phylogeny remain…”
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Reagent and laboratory contamination can critically impact sequence-based microbiome analyses by Salter, Susannah J, Cox, Michael J, Turek, Elena M, Calus, Szymon T, Cookson, William O, Moffatt, Miriam F, Turner, Paul, Parkhill, Julian, Loman, Nicholas J, Walker, Alan W

“…The study of microbial communities has been revolutionised in recent years by the widespread adoption of culture independent analytical techniques such as 16S…”
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Therapeutic modulation of intestinal dysbiosis by Walker, Alan W., Lawley, Trevor D.

“…The human gastrointestinal tract is home to an extremely numerous and diverse collection of microbes, collectively termed the “intestinal microbiota”. This…”
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