Search Results - "Walikonis, Randall"

Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits by Ru, Wenjuan, Liu, Xin, Bae, Chilman, Shi, Yuqiang, Walikonis, Randall, Mo Chung, Jin, Tang, Shao-Jun

“…HIV-1 infection of the nervous system causes various neurological diseases, and synaptic degeneration is likely a critical step in the neuropathogenesis. Our…”
Get full text

The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment by Sanders, Shaun S, Hernandez, Luiselys M, Soh, Heun, Karnam, Santi, Walikonis, Randall S, Tzingounis, Anastasios V, Thomas, Gareth M

“…The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expressed in the hippocampus and is the only PAT predicted to bind Type-I PDZ domain-containing proteins…”
Get full text

Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression by Brown, Joshua C., Petersen, Amber, Zhong, Ling, Himelright, Miranda L., Murphy, Jessica A., Walikonis, Randall S., Gerges, Nashaat Z.

“…Dysfunction of the proteins regulating synaptic function can cause synaptic plasticity imbalance that underlies neurological disorders such as intellectual…”
Get full text

Tonic PKA Activity Regulates SK Channel Nanoclustering and Somatodendritic Distribution by Abiraman, Krithika, Sah, Megha, Walikonis, Randall S., Lykotrafitis, George, Tzingounis, Anastasios V.

“…Small-conductance calcium-activated potassium (SK) channels mediate a potassium conductance in the brain and are involved in synaptic plasticity, learning, and…”
Get full text

Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway by Lim, Chol Seung, Walikonis, Randall S.

“…During central nervous system development, growth factors and their associated receptor protein tyrosine kinases regulate many neuronal functions such as…”
Get full text

Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual disability by Proos, Anne, Gécz, Jozef, Hackett, Anna, Ramsden, Sarah L, Shoubridge, Cheryl, Gardner, Alison, Stratton, Michael R, Harvey, Robert J, Raymond, F Lucy, Field, Michael, Murphy, Jessica A, Puusepp, Helen, Schwartz, Charles E, Shaw, Marie, Turner, Gill, Abidi, Fatima, Walikonis, Randall S, Futreal, P Andrew, Tarpey, Patrick S, Stevenson, Roger E, Rujirabanjerd, Sinitdhorn, Boyle, Jackie

“…The first family identified as having a nonsyndromic intellectual disability was mapped in 1988. Here we show that a mutation of IQSEC2, encoding a guanine…”
Get full text

Daily Brief Heat Therapy Reduces Seizures in A350V IQSEC2 Mice and Is Associated with Correction of AMPA Receptor-Mediated Synaptic Dysfunction by Jada, Reem, Borisov, Veronika, Laury, Eliezer, Halpert, Shmuel, Levy, Nina S, Wagner, Shlomo, Netser, Shai, Walikonis, Randall, Carmi, Ido, Berlin, Shai, Levy, Andrew P

“…Purposeful induction of fever for healing, including the treatment of epilepsy, was used over 2000 years ago by Hippocrates. More recently, fever has been…”
Get full text

An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors by Rogers, Eli J, Jada, Reem, Schragenheim-Rozales, Kinneret, Sah, Megha, Cortes, Marisol, Florence, Matthew, Levy, Nina S, Moss, Rachel, Walikonis, Randall S, Palty, Raz, Shalgi, Reut, Lichtman, Daniela, Kavushansky, Alexandra, Gerges, Nashaat Z, Kahn, Itamar, Umanah, George K E, Levy, Andrew P

“…We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular…”
Get full text

Topography of native SK channels revealed by force nanoscopy in living neurons by Maciaszek, Jamie L, Soh, Heun, Walikonis, Randall S, Tzingounis, Anastasios V, Lykotrafitis, George

“…The spatial distribution of ion channels is an important determinant of neuronal excitability. However, there are currently no quantitative techniques to map…”
Get full text

Fusion of Microglia with Pyramidal Neurons after Retroviral Infection by Ackman, James B, Siddiqi, Faez, Walikonis, Randall S, LoTurco, Joseph J

“…The neurogenic potential of the postnatal neocortex has not been tested previously with a combination of both retroviral and bromodeoxyuridine (BrdU) labeling…”
Get full text

The Receptor Tyrosine Kinase Met and Its Ligand Hepatocyte Growth Factor are Clustered at Excitatory Synapses and Can Enhance Clustering of Synaptic Proteins by Tyndall, Stephanie J., Walikonis, Randall S.

“…The receptor protein tyrosine kinase Met and its ligand, hepatocyte growth factor, regulate cellular morphology, intercellular adhesion, and interactions among…”
Get full text

Septin 6 Regulates the Cytoarchitecture of Neurons through Localization at Dendritic Branch Points and Bases of Protrusions by Cho, S.J., Dongguk University, Gyeongju, Republic of Korea, Lee, H.S., Dongguk University, Gyeongju, Republic of Korea, Dutta, Samikshan, Dongguk University, Gyeongju, Republic of Korea, Song, J.Y., Dongguk University, Gyeongju, Republic of Korea, Walikonis, Randall, University of Connecticut, CT, USA, Moon, I.S., Dongguk University, Gyeongju, Republic of Korea

“…Septins, a conserved family of GTP-binding proteins with a conserved role in cytokinesis, are present in eukaryotes ranging from yeast to mammals. Septins are…”
Get full text

Identification of Proteins in the Postsynaptic Density Fraction by Mass Spectrometry by Walikonis, Randall S, Jensen, Ole N, Mann, Matthias, Provance, D. William, Jr, Mercer, John A, Kennedy, Mary B

“…Our understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the…”
Get full text

BRAG1, a Sec7 domain-containing protein, is a component of the postsynaptic density of excitatory synapses by Murphy, Jessica A., Jensen, Ole N., Walikonis, Randall S.

“…The postsynaptic density (PSD) at excitatory synapses is a dynamic complex of glutamatergic receptors and associated proteins that governs synaptic structure…”
Get full text

Hepatocyte growth factor-induced enhancement of dendritic branching is blocked by inhibitors of N-methyl-D-aspartate receptors and calcium/calmodulin-dependent kinases by Tyndall, Stephanie J., Patel, Sandip J., Walikonis, Randall S.

“…Hepatocyte growth factor (HGF) and its receptor, Met, are clustered at excitatory synapses and can enhance N‐methyl‐D‐aspartate (NMDA) receptor current and…”
Get full text

Discs large 5 is required for polarization of citron kinase in mitotic neural precursors by Chang, YoonJeung, Klezovitch, Olga, Walikonis, Randall S., Vasioukhin, Valera, LoTurco, Joseph J.

“…Citron kinase (CitK), a protein essential to neurogenic cell division in the central nervous system, is highly polarized in neural progenitors. The mechanisms…”
Get full text

RanBPM regulates the progression of neuronal precursors through M‐phase at the surface of the neocortical ventricular zone by Chang, YoonJeung, Paramasivam, Murugan, Girgenti, Matthew J., Walikonis, Randall S., Bianchi, Elisabetta, LoTurco, Joseph J.

“…Many of the mitoses that produce pyramidal neurons in neocortex occur at the dorsolateral surface of the lateral ventricles in the embryo. RanBPM was found in…”
Get full text

Septin 6 localizes to microtubules in neuronal dendrites by Moon, Il Soo, Lee, HyunSook, Walikonis, Randall S.

“…In neuronal dendrites, septins localize to the base of the spine, a unique position which is sandwiched between the microtubule (MT)-rich dendritic shaft and…”
Get full text

Novel Missense Mutation A789V in IQSEC2 Underlies X-Linked Intellectual Disability in the MRX78 Family by Kalscheuer, Vera M, James, Victoria M, Himelright, Miranda L, Long, Philip, Oegema, Renske, Jensen, Corinna, Bienek, Melanie, Hu, Hao, Haas, Stefan A, Topf, Maya, Hoogeboom, A Jeannette M, Harvey, Kirsten, Walikonis, Randall, Harvey, Robert J

“…Disease gene discovery in neurodevelopmental disorders, including X-linked intellectual disability (XLID) has recently been accelerated by next-generation DNA…”
Get full text

A simple method for combined fluorescence in situ hybridization and immunocytochemistry by Moon, Il Soo, Cho, Sun-Jung, Jin, Ingnyol, Walikonis, Randall

“…By combining in situ hybridization (ISH) and immunocytochemistry (IC), microscopic topological localization of mRNAs and proteins can be determined. Although…”
Get more information