Search Results - "Walia, Yashna"

S-Nitrosylation: An Emerging Paradigm of Redox Signaling by Fernando, Veani, Zheng, Xunzhen, Walia, Yashna, Sharma, Vandana, Letson, Joshua, Furuta, Saori

“…Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine by NO synthase (NOS). Abnormal NO levels in mammalian cells are…”
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S-Nitrosylation in Tumor Microenvironment by Sharma, Vandana, Fernando, Veani, Letson, Joshua, Walia, Yashna, Zheng, Xunzhen, Fackelman, Daniel, Furuta, Saori

“…S-nitrosylation is a selective and reversible post-translational modification of protein thiols by nitric oxide (NO), which is a bioactive signaling molecule,…”
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PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia by Beck, Dominik, Cao, Honghui, Tian, Feng, Huang, Yizhou, Jiang, Miao, Zhao, Han, Tai, Xiaolu, Xu, Wenqian, Kosasih, Hansen J., Kealy, David J., Zhao, Weiye, Taylor, Samuel J., Couttas, Timothy A., Song, Gaoxian, Chacon-Fajardo, Diego, Walia, Yashna, Wang, Meng, Dowle, Adam A., Holding, Andrew N., Bridge, Katherine S., Zhang, Chao, Wang, Jin, Mi, Jian-Qing, Lock, Richard B., de Bock, Charles E., Jing, Duohui

“…The epigenetic landscape plays a critical role in cancer progression, yet its therapeutic potential remains underexplored. Glucocorticoids are essential…”
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Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ by Ren, Gang, Zheng, Xunzhen, Bommarito, Matthew, Metzger, Samantha, Walia, Yashna, Letson, Joshua, Schroering, Allen, Kalinoski, Andrea, Weaver, David, Figy, Christopher, Yeung, Kam, Furuta, Saori

“…One third of newly diagnosed breast cancers in the US are early-stage lesions. The etiological understanding and treatment of these lesions have become major…”
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Reconstituting Breast Tissue with Organotypic Three-dimensional Co-culture of Epithelial and Stromal Cells in Discontinuous Extracellular Matrices by Ren, Gang, Sharma, Vandana, Letson, Joshua, Walia, Yashna, Fernando, Veani, Furuta, Saori

“…Co-culture systems utilizing reconstituted or synthetic extracellular matrix (ECM) and micropatterning techniques have enabled the reconstruction of surface…”
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Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish by LeCorgne, Hunter, Tudosie, Andrew M, Lavik, Kari, Su, Robin, Becker, Kathryn N, Moore, Sara, Walia, Yashna, Wisner, Alexander, Koehler, Daniel, Alberts, Arthur S, Williams, Frederick E, Eisenmann, Kathryn M

“…The mammalian Diaphanous-related (mDia) formins are cytoskeletal regulators that assemble and, in some cases, bundle filamentous actin (F-actin), as well as…”
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The landscape of alterations affecting epigenetic regulators in T‐cell acute lymphoblastic leukemia: Roles in leukemogenesis and therapeutic opportunities by Walia, Yashna, Bock, Charles E., Huang, Yizhou

“…T‐cell acute lymphoblastic leukemia (T‐ALL) is an aggressive malignancy accounting for 10%–15% of pediatric and 20%–25% of adult ALL cases. Epigenetic…”
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Correction of arginine metabolism with sepiapterin—the precursor of nitric oxide synthase cofactor BH4—induces immunostimulatory-shift of breast cancer by Zheng, Xunzhen, Fernando, Veani, Sharma, Vandana, Walia, Yashna, Letson, Joshua, Furuta, Saori

“…[Display omitted] Immunotherapy is a first-line treatment for many tumor types. However, most breast tumors are immuno-suppressive and only modestly respond to…”
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Effect of S-Nitrosylation on HER2 Protein Expression and Activity by Walia, Yashna

“…Among women in the US, breast cancer is the second leading cause of cancer related death, only preceded by lung cancer. This study primarily focuses on HER2,…”
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Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH 4 -induces immunostimulatory-shift of breast cancer by Zheng, Xunzhen, Fernando, Veani, Sharma, Vandana, Walia, Yashna, Letson, Joshua, Furuta, Saori

“…Immunotherapy is a first-line treatment for many tumor types. However, most breast tumors are immuno-suppressive and only modestly respond to immunotherapy. We…”
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