Search Results - "Walesch, K"
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SIAH3 is frequently epigenetically silenced in cancer and regulates mitochondrial metabolism
Published in International journal of cancer (30-09-2024)“…Of the seven in absentia homologue (SIAH) family, three members have been identified in the human genome. In contrast to the E3 ubiquitin ligase encoding SIAH1…”
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RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice
Published in Oncogene (09-04-2020)“…Kidney cancer incidences are rising globally, thereby fueling the demand for targeted therapies and precision medicine. In our previous work, we have…”
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Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function
Published in Clinical epigenetics (04-12-2019)“…Cancer still is one of the leading causes of death and its death toll is predicted to rise further. We identified earlier the potential tumour suppressor…”
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Promoter Methylation Status of Ras-Association Domain Family Member in Pheochromocytoma
Published in Frontiers in endocrinology (Lausanne) (19-02-2015)“…Pheochromocytomas (PCCs) are rare neuroendocrine tumours that arise from the medulla of the adrenal gland or the sympathetic ganglia and are characterised by…”
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Aberrant Promoter Methylation of the Tumour Suppressor RASSF10 and Its Growth Inhibitory Function in Breast Cancer
Published in Cancers (25-02-2016)“…Breast cancer is the most common cancer in women, with 1.7 million new cases each year. As early diagnosis and prognosis are crucial factors in cancer…”
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RASSF10 Is a TGFβ-Target That Regulates ASPP2 and E-Cadherin Expression and Acts as Tumor Suppressor That Is Epigenetically Downregulated in Advanced Cancer
Published in Cancers (08-12-2019)“…The (RASSF) encodes members of tumor suppressor genes which are frequently inactivated in human cancers. Here, the function and the regulation of RASSF10, that…”
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The apoptosis associated tyrosine kinase gene is frequently hypermethylated in human cancer and is regulated by epigenetic mechanisms
Published in Genes & cancer (01-09-2014)“…Epigenetic gene inactivation through promoter hypermethylation is an important aberration involved in the silencing of tumor-associated genes in cancer. Here…”
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Claudin11 Promoter Hypermethylation Is Frequent in Malignant Melanoma of the Skin, but Uncommon in Nevus Cell Nevi
Published in Cancers (07-07-2015)“…Epigenetic inactivation of tumor-related genes is an important characteristic in the pathology of human cancers, including melanomagenesis. We analyzed the…”
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Promoter methylation status of Ras-association domain family members in pheochromocytoma
Published in Frontiers in endocrinology (Lausanne) (2015)“…Pheochromocytomas (PCCs) are rare neuroendocrine tumors that arise from the medulla of the adrenal gland or the sympathetic ganglia and are characterized by…”
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The tumor suppressor RASSF10 is upregulated upon contact inhibition and frequently epigenetically silenced in cancer
Published in Oncogenesis (New York, NY) (01-06-2012)“…The Ras association domain family (RASSF) comprises a group of tumor suppressors that are frequently epigenetically inactivated in various tumor entities and…”
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Self concept and parental images in patients with affective disorders--a clinical study with the Giessen Test
Published in Psychotherapie, Psychosomatik, medizinische Psychologie (01-03-2000)“…The relationship between self, ideal self and normative self was studied in a sample of 139 patients with affective disorders and 73 patients with orthopaedic…”
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