Exposures of male rats to environmental chemicals [bisphenol A and di (2‐ethylhexyl) phthalate] affected expression of several proteins in the developing epididymis

Summary Hormonally active agents are released into the environment from industrial and manufacturing activity. Evidence in the literature indicates that impaired reproductive capacity in wildlife and laboratory species is associated with chemical exposures. In particular, bisphenol A (BPA) and di (2...

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Published in:	Andrology (Oxford) Vol. 6; no. 1; pp. 214 - 222
Main Authors:	Abdel‐Maksoud, F. M., Knight, R., Waler, K., Yaghoubi‐Yeganeh, N., Olukunle, J. O., Thompson, H., Panizzi, J. R., Akingbemi, B. T.
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-01-2018
Subjects:	Air Pollutants, Occupational - toxicity androgen Androgens Animals Benzhydryl Compounds - toxicity Bisphenol A chemicals Diethylhexyl Phthalate - toxicity endocrine disruptors Environmental Exposure - adverse effects epididymis Epididymis - drug effects estrogen Female Gene Expression Regulation, Developmental - drug effects Male Maternal Exposure - adverse effects Phenols - toxicity Plasticizers - toxicity Pregnancy Prenatal Exposure Delayed Effects - pathology Rats Rats, Long-Evans sexual differentiation androgen estrogen epididymis chemicals sexual differentiation endocrine disruptors
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Summary:	Summary Hormonally active agents are released into the environment from industrial and manufacturing activity. Evidence in the literature indicates that impaired reproductive capacity in wildlife and laboratory species is associated with chemical exposures. In particular, bisphenol A (BPA) and di (2‐ethylhexyl) phthalate (DEHP) have generated public interest due to their presence in several consumer products. In this study, we determined that expression of steroid hormone receptors (estrogen and androgen receptors), Wnt4, and β‐catenin was greater (p < 0.05) in the rat epididymis at 35 days of age compared to 21 and 90 days. Second, timed‐pregnant Long‐Evans dams were exposed to the chemicals BPA and DEHP by gavage from gestational days 12–21. The caput epididymis was collected from cohorts of male offspring at 35 and 90 days of age and processed for Western blot analysis. Results showed that prenatal BPA and DEHP exposures affected (p < 0.05) expression of estrogen and androgen receptor, Wnt4, β‐catenin, MAPK, and HOXD4 protein in the epididymis. Data have implications for morphological development of the epididymis, a possibility that would be explored in future studies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2047-2919 2047-2927
DOI:	10.1111/andr.12451