Search Results - "Walejko, Jacquelyn M."

Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats by McGarrah, Robert W, Zhang, Guo-Fang, Christopher, Bridgette A, Deleye, Yann, Walejko, Jacquelyn M, Page, Stephani, Ilkayeva, Olga, White, Phillip J, Newgard, Christopher B

“…Elevations in circulating levels of branched-chain amino acids (BCAAs) are associated with a variety of cardiometabolic diseases and conditions. Restriction of…”
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Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart by Walejko, Jacquelyn M., Christopher, Bridgette A., Crown, Scott B., Zhang, Guo-Fang, Pickar-Oliver, Adrian, Yoneshiro, Takeshi, Foster, Matthew W., Page, Stephani, van Vliet, Stephan, Ilkayeva, Olga, Muehlbauer, Michael J., Carson, Matthew W., Brozinick, Joseph T., Hammond, Craig D., Gimeno, Ruth E., Moseley, M. Arthur, Kajimura, Shingo, Gersbach, Charles A., Newgard, Christopher B., White, Phillip J., McGarrah, Robert W.

“…Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major…”
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Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever by Yoneshiro, Takeshi, Kataoka, Naoya, Walejko, Jacquelyn M, Ikeda, Kenji, Brown, Zachary, Yoneshiro, Momoko, Crown, Scott B, Osawa, Tsuyoshi, Sakai, Juro, McGarrah, Robert W, White, Phillip J, Nakamura, Kazuhiro, Kajimura, Shingo

“…Importing necessary metabolites into the mitochondrial matrix is a crucial step of fuel choice during stress adaptation. Branched chain-amino acids (BCAAs) are…”
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Diabetes Leads to Alterations in Normal Metabolic Transitions of Pregnancy as Revealed by Time-Course Metabolomics by Walejko, Jacquelyn M., Chelliah, Anushka, Keller-Wood, Maureen, Wasserfall, Clive, Atkinson, Mark, Gregg, Anthony, Edison, Arthur S.

“…Women with diabetes during pregnancy are at increased risk of poor maternal and neonatal outcomes. Despite this, the effects of pre-gestational (PGDM) or…”
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Global Metabolomics of the Placenta Reveals Distinct Metabolic Profiles between Maternal and Fetal Placental Tissues Following Delivery in Non-Labored Women by Walejko, Jacquelyn M, Chelliah, Anushka, Keller-Wood, Maureen, Gregg, Anthony, Edison, Arthur S

“…We evaluated the metabolic alterations in maternal and fetal placental tissues from non-labored women undergoing cesarean section using samples collected from…”
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Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity by Grenier-Larouche, Thomas, Coulter Kwee, Lydia, Deleye, Yann, Leon-Mimila, Paola, Walejko, Jacquelyn M., McGarrah, Robert W., Marceau, Simon, Trahan, Sylvain, Racine, Christine, Carpentier, André C., Lusis, Aldons J., Ilkayeva, Olga, Vohl, Marie-Claude, Huertas-Vazquez, Adriana, Tchernof, André, Shah, Svati H., Newgard, Christopher B., White, Phillip J.

“…Hepatic de novo lipogenesis is influenced by the branched-chain α-keto acid dehydrogenase (BCKDH) kinase (BCKDK). Here, we aimed to determine whether…”
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Integrated Metabolomics and Transcriptomics Suggest the Global Metabolic Response to 2-Aminoacrylate Stress in Salmonella enterica by Borchert, Andrew J, Walejko, Jacquelyn M, Guennec, Adrien Le, Ernst, Dustin C, Edison, Arthur S, Downs, Diana M

“…In , 2-aminoacrylate (2AA) is a reactive enamine intermediate generated during a number of biochemical reactions. When the 2-iminobutanoate/2-iminopropanoate…”
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Maternal hypercortisolemia alters placental metabolism: a multiomics view by Joseph, Serene, Walejko, Jacquelyn M, Zhang, Sicong, Edison, Arthur S, Keller-Wood, Maureen

“…Previous studies have suggested that increases in maternal cortisol or maternal stress in late pregnancy increase the risk of stillbirth at term. In an ovine…”
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Gut microbiota and serum metabolite differences in African Americans and White Americans with high blood pressure by Walejko, Jacquelyn M., Kim, Seungbum, Goel, Ruby, Handberg, Eileen M., Richards, Elaine M., Pepine, Carl J., Raizada, Mohan K.

“…Black Americans have greater rates, severity and resistance to treatment of hypertension than White Americans. The gut microbiota and its metabolites may…”
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Multiomics approach reveals metabolic changes in the heart at birth by Walejko, Jacquelyn M, Koelmel, Jeremy P, Garrett, Timothy J, Edison, Arthur S, Keller-Wood, Maureen

“…During late gestation, the fetal heart primarily relies on glucose and lactate to support rapid growth and development. Although numerous studies describe…”
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Chronic maternal cortisol excess during late gestation leads to metabolic alterations in the newborn heart by Walejko, Jacquelyn M, Antolic, Andrew, Koelmel, Jeremy P, Garrett, Timothy J, Edison, Arthur S, Keller-Wood, Maureen

“…Our laboratory has previously shown in an ovine model of pregnancy that abnormal elevations in maternal cortisol during late gestation lead to increased fetal…”
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Abstract P167: Altered Gut Microbiome Contributes to Metabolite Biomarkers in Patients With Pulmonary Hypertension by Kim, Seungbum, Walejko, Jacquelyn M, Rigatto, Katya, Jordan, Ray, Shapiro, Brian, Pepine, Carl J, Richards, Elaine M, Raizada, Mohan K

“…Abstract only Objectives: Pulmonary arterial hypertension (PAH) is a cardiopulmonary disease without effective cure. The objective of this study is to test the…”
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Abstract P143: Multifaceted Roles of Gut Microbiome and Bacterial Metabolites in Pulmonary Arterial Hypertension by Kim, Seungbum S, Walejko, Jacquelyn M, Rigatto, Katya, Ray, Jordan, Gazzana, Marcelo B, Knorst, Marli M, Richards, Elaine M, Shapiro, Brian, Pepine, Carl J, Raizada, Mohan K

“…Abstract only Objectives: Pulmonary arterial hypertension (PAH) is a deadly disease without any effective cure. Identification of the PAH-associated gut…”
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