Search Results - "Waleed Gaber, M."
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Asprosin, a Fasting-Induced Glucogenic Protein Hormone
Published in Cell (21-04-2016)“…Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that…”
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2
Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model
Published in International journal of radiation oncology, biology, physics (01-02-2022)“…Compared with photon cranial radiation therapy (X-CRT), proton cranial radiation therapy (P-CRT) offers potential advantages in limiting radiation-induced…”
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3
Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
Published in Nature communications (09-10-2020)“…Mutations in the skeletal muscle Ca 2+ release channel, the type 1 ryanodine receptor (RYR1), cause malignant hyperthermia susceptibility (MHS) and a…”
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4
Improved Intratumoral Oxygenation Through Vascular Normalization Increases Glioma Sensitivity to Ionizing Radiation
Published in International journal of radiation oncology, biology, physics (01-04-2010)“…Purpose Ionizing radiation, an important component of glioma therapy, is critically dependent on tumor oxygenation. However, gliomas are notable for areas of…”
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5
Exercise ameliorates neurocognitive impairments in a translational model of pediatric radiotherapy
Published in Neuro-oncology (Charlottesville, Va.) (09-04-2018)“…While cranial radiation therapy (CRT) is an effective treatment, healthy areas surrounding irradiation sites are negatively affected. Frontal lobe functions…”
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6
Cross-Sectional Characterization of Local Brain Network Connectivity Pre and Post Breast Cancer Treatment and Distinct Association With Subjective Cognitive and Psychological Function
Published in Frontiers in neurology (29-10-2021)“…We aimed to characterize local brain network connectivity in long-term breast cancer survivors compared to newly diagnosed patients. Functional magnetic…”
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Radiation-Induced Astrogliosis and Blood-Brain Barrier Damage Can Be Abrogated Using Anti-TNF Treatment
Published in International journal of radiation oncology, biology, physics (01-07-2009)“…Purpose In this article, we investigate the role of tumor necrosis factor-alpha (TNF) in the initiation of acute damage to the blood-brain barrier (BBB) and…”
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8
LOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma
Published in Genes & diseases (01-01-2023)“…Osteosarcoma is a malignant bone tumor that commonly occurs in the pediatric population. Despite the use of chemotherapy and surgery, metastasis remains to be…”
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Hyperoxia Disrupts Lung Lymphatic Homeostasis in Neonatal Mice
Published in Antioxidants (01-03-2023)“…Inflammation causes bronchopulmonary dysplasia (BPD), a common lung disease of preterm infants. One reason this disease lacks specific therapies is the paucity…”
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Effects of fractionated radiation on the brain vasculature in a murine model: blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes
Published in International journal of radiation oncology, biology, physics (01-11-2006)“…Radiation therapy of CNS tumors damages the blood-brain barrier (BBB) and normal brain tissue. Our aims were to characterize the short- and long-term effects…”
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11
Olfactory Memory Impairment Differs by Sex in a Rodent Model of Pediatric Radiotherapy
Published in Frontiers in behavioral neuroscience (02-08-2018)“…Although an effective treatment for pediatric brain tumors, cranial radiation therapy (CRT) damages surrounding healthy tissue, thereby disrupting brain…”
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Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy
Published in Neural plasticity (01-01-2013)“…Brain cancer is a common type of childhood malignancy, and radiotherapy (RT) is a mainstay of treatment. RT is effective for tumor eradication, and survival…”
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13
Radiation-Induced Growth Retardation and Microstructural and Metabolite Abnormalities in the Hippocampus
Published in Neural plasticity (01-01-2016)“…Cranial radiotherapy (CRT) increases survival in pediatric brain-tumor patients but can cause deleterious effects. This study evaluates the acute and long-term…”
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Imaging Radiation-Induced Gastrointestinal, Bone Marrow Injury and Recovery Kinetics Using 18F-FDG PET
Published in PloS one (2017)“…Positron emission tomography using 18F-Fluro-deoxy-glucose (18F-FDG) is a useful tool to detect regions of inflammation in patients. We utilized this imaging…”
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15
Radiation Combined Injury Models to Study the Effects of Interventions and Wound Biomechanics
Published in Radiation research (01-12-2014)“…In the event of a nuclear detonation, a considerable number of projected casualties will suffer from combined radiation exposure and burn and/or wound injury…”
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16
Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models
Published in Journal of immunology research (01-01-2017)“…One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The…”
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Effects of Irradiation on Brain Vasculature Using an In Situ Tumor Model
Published in International journal of radiation oncology, biology, physics (01-03-2012)“…Purpose Damage to normal tissue is a limiting factor in clinical radiotherapy (RT). We tested the hypothesis that the presence of tumor alters the response of…”
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A chitosan/β-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer
Published in Biomaterials (01-05-2010)“…Abstract We report here the development of a chitosan/β-glycerophosphate(Ch/β-GP) thermo-sensitive gel to deliver ellagic acid (EA) for cancer treatment. The…”
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19
Echocardiography Differentiates Lethally Irradiated Whole-Body From Partial-Body Exposed Rats
Published in Frontiers in cardiovascular medicine (16-10-2018)“…Acute radiation syndrome (ARS) affects morbidity and mortality dependent on the amount of body exposed. We propose the use of echocardiography (EC) to…”
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Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid
Published in Cancer chemotherapy and pharmacology (01-09-2011)“…Purpose Anticancer agents are useful for treating brain tumors, but sub therapeutic concentrations due to decreased blood–brain barrier (BBB) penetration limit…”
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