Search Results - "Waldon, Daniel J."

Localization and Quantification of Drugs in Animal Tissues by Use of Desorption Electrospray Ionization Mass Spectrometry Imaging by Vismeh, Ramin, Waldon, Daniel J, Teffera, Yohannes, Zhao, Zhiyang

“…Mass spectrometric imaging (MSI) has emerged as a powerful technique to obtain spatial arrangement of individual molecular ions in animal tissues. Ambient…”
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Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe by Colca, Jerry R, McDonald, William G, Waldon, Daniel J, Leone, Joseph W, Lull, June M, Bannow, Carol A, Lund, Eric T, Mathews, W Rodney

“…Thiazolidinediones address underlying causes of type 2 diabetes, although their mechanism of action is not clearly understood. The compounds are thought to…”
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A Novel Bioactivation Pathway for 2-[2-(2,6-Dichlorophenyl)aminophenyl]ethanoic Acid (Diclofenac) Initiated by Cytochrome P450-Mediated Oxidative Decarboxylation by GRILLO, Mark P, JI MA, TEFFERA, Yohannes, WALDON, Daniel J

“…Diclofenac (2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid), a nonsteroidal antiinflammatory drug, undergoes bioactivation by cytochrome P450 oxidation to…”
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STUDIES ON THE CHEMICAL REACTIVITY OF DICLOFENAC ACYL GLUCURONIDE WITH GLUTATHIONE: IDENTIFICATION OF DICLOFENAC-S-ACYL-GLUTATHIONE IN RAT BILE by GRILLO, Mark P, KNUTSON, Charles G, SANDERS, Phillip E, WALDON, Daniel J, FENGMEI HUA, WARE, Joseph A

“…Diclofenac, a nonsteroidal anti-inflammatory drug, is metabolized to a reactive acyl glucuronide that has been proposed to mediate toxic adverse drug reactions…”
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Identification of Quinone Imine Containing Glutathione Conjugates of Diclofenac in Rat Bile by Waldon, Daniel J, Teffera, Yohannes, Colletti, Adria E, Liu, Jingzhou, Zurcher, Danielle, Copeland, Katrina W, Zhao, Zhiyang

“…High-resolution accurate MS with an LTQ-Orbitrap was used to identify quinone imine metabolites derived from the 5-hydroxy (5-OH) and 4 prime-hydroxy (4′-OH)…”
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Desorption electrospray ionization tissue imaging using heated nebulizing gas and high-resolution accurate mass spectra by Waldon, Daniel J., Zhao, Zhiyang, Teffera, Yohannes

“…A new method for tissue imaging using desorption electrospray ionization (DESI) mass spectrometry is described. The technique utilizes a DESI source with a…”
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Cross-linking in the Living Cell Locates the Site of Action of Oxazolidinone Antibiotics by Colca, Jerry R., McDonald, William G., Waldon, Daniel J., Thomasco, Lisa M., Gadwood, Robert C., Lund, Eric T., Cavey, Gregory S., Mathews, W. Rodney, Adams, Lonnie D., Cecil, Eric T., Pearson, James D., Bock, Jeffrey H., Mott, John E., Shinabarger, Dean L., Xiong, Liqun, Mankin, Alexander S.

“…Oxazolidinone antibiotics, an important new class of synthetic antibacterials, inhibit protein synthesis by interfering with ribosomal function. The exact site…”
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Minoxidil Sulfate Is the Active Metabolite that Stimulates Hair Follicles by Buhl, Allen E, Waldon, Daniel J, Baker, Carolyn A, Johnson, Garland A

“…An important step in understanding minoxidil's mechanism of action on hair follicles was to determine the drug's active form. We used organ-cultured vibrissa…”
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Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture by Buhl, Allen E., Waldon, Daniel J., Kawabe, Thomas T., Holland, J. Michael

“…Minoxidil, a potent vasodilator, stimulates the growth of terminal hair from vellus or miniaturized follicles in balding scalp. To study minoxidil's action on…”
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Potassium Channel Conductance: A Mechanism Affecting Hair Growth both In Vitro and In Vivo by Buhl, Allen E, Waldon, Daniel J, Conrad, Steven J, Mulholland, Michael J, Shull, Kathy L, Kubicek, Marc F, Johnson, Garland A, Brunden, Marshall N, Stefanski, Kevin J, Stehle, Randall G, Gadwood, Robert C, Kamdar, Bharat V, Thomasco, Lisa M, Schostarez, Heinrich J, Schwartz, Theresa M, Diani, Arthur R

“…The opening of intracellular potassium channels his been suggested as a mechanism regulating hair growth. Enhancing the flu of potassium ions is a mechanism…”
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Desorption electrospray ionization tissue imaging using heated nebulizing gas and high-resolution accurate mass spectra: Tissue imaging with DESI using HRMS by Waldon, Daniel J., Zhao, Zhiyang, Teffera, Yohannes

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Identification of a novel glutathione conjugate of diclofenac by LTQ-Orbitrap by Teffera, Yohannes, Waldon, Daniel J, Colletti, Adria E, Albrecht, Brian K, Zhao, Zhiyang

“…High resolution accurate MS with an LTQ-Orbitrap identified two novel metabolites of diclofenac in rat bile and rat and human hepatocyte incubations: a…”
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Solution structures of stromelysin complexed to thiadiazole inhibitors by Stockman, Brian J., Waldon, Daniel J., Gates, Jo A., Scahill, Terrence A., Kloosterman, David A., Mizsak, Stephen A., Jacobsen, E. Jon, Belonga, Kenneth L., Mitchell, Mark A., Mao, Boryeu, Petke, James D., Goodman, Linda, Powers, Elaine A., Ledbetter, Steven R., Kaytes, Paul S., Vogeli, Gabriel, Marshall, Vincent P., Petzold, Gary L., Poorman, Roger A.

“…Unregulated or overexpressed matrix metalloproteinases (MMPs), including stromelysin, collagenase, and gelatinase, have been implicated in several pathological…”
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Potassium channel conductance as a control mechanism in hair follicles by Buhl, Allen E., Conrad, Steven J., Waldon, Daniel J., Brunden, Marshall N.

“…The opening of intracellular potassium channels is a common mechanism of action for a set of anti-hypertensive drugs that includes the hair-growth-inducing…”
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Potassium Channel Conductance as a Control Mechanism in Hair Follicles by Buhl, Allen E., Conrad, Steven J., Waldon, Daniel J., Brunden, Marshall N.

“…Abstract only…”
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Stereoselective hydroxylation of nonpeptidic HIV protease inhibitors by CYP2D6 by Zhao, Zhiyang, Koeplinger, Kenneth A., Waldon, Daniel J.

“…PNU‐106893, N‐{3‐[1‐(4‐hydroxy‐2‐oxo‐6‐phenyl‐6‐propyl‐5,6‐dihydro‐2H‐pyran‐3‐yl)‐2,2‐dimethylpropyl]phenyl}‐1‐methyl‐1H‐imidazole‐4‐sulfonamide, is a…”
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Hair-Specific Expression of Chloramphenicol Acetyltransferase in Transgenic Mice Under the Control of an Ultra-High-sulfur Keratin Promoter by McNab, Alistair R., Andrus, Paula, Wagner, Thomas E., Buhl, Allen E., Waldon, Daniel J., Kawabe, Thomas K., Rea, Thomas J., Groppi, Vince, Vogeli, Gabriel

“…We have generated a transgenic mouse line by microinjection of a chimeric DNA fragment (KER-CAT) containing a hair-specific, murine ultra-high-sulfur keratin…”
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High-sulfur protein gene expression in a transgenic mouse by Vogeli, G, Wood, L, McNab, A R, Kaytes, P, Wagner, T E, Rea, T J, Groppi, V, Waldon, D J, Kawabe, T T, Buhl, A E

“…We analyzed the effect of minoxidil on hair follicles isolated from transgenic mice. These transgenic animals synthesize the reporter enzyme CAT in their hair…”
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