Search Results - "Waldman, S. A."
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Antiobesity Pharmacotherapy: New Drugs and Emerging Targets
Published in Clinical pharmacology and therapeutics (01-01-2014)“…Obesity is a growing pandemic, and related health and economic costs are staggering. Pharmacotherapy, partnered with lifestyle modifications, forms the core of…”
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Managing Innovation to Maximize Value Along the Discovery‐Translation‐Application Continuum
Published in Clinical pharmacology and therapeutics (01-01-2017)“…Success in pharmaceutical development led to a record 51 drugs approved in the past year, surpassing every previous year since 1950. Technology innovation…”
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Clinical Pharmacology & Therapeutics: Past, Present, and Future
Published in Clinical pharmacology and therapeutics (01-03-2017)“…Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development,…”
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Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics
Published in Clinical pharmacology and therapeutics (01-09-2017)“…Clinical Pharmacology & Therapeutics (CPT) is an established voice of the discipline, a trusted source of new knowledge showcasing discovery, translation, and…”
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Big Data Transforms Discovery-Utilization Therapeutics Continuum
Published in Clinical pharmacology and therapeutics (01-03-2016)“…Enabling omic technologies adopt a holistic view to produce unprecedented insights into the molecular underpinnings of health and disease, in part, by…”
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Bioinnovation Enterprise: An engine driving breakthrough therapies
Published in Clinical pharmacology and therapeutics (01-01-2016)“…Biological advances have radically expanded our insights into the underpinnings of health and disease. New knowledge has formed the substrate for…”
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Clinical Pharmacology & Therapeutics: The Next Five Years
Published in Clinical pharmacology and therapeutics (01-01-2015)“…It has been nearly ten years since we joined the editorial organization of Clinical Pharmacology & Therapeutics (CPT), as part of the American Society for…”
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Molecular Insights Provide the Critical Path to Disease Mitigation
Published in Clinical pharmacology and therapeutics (01-01-2014)“…The revolution in scientific innovation, driven by the engines of enabling technologies, is increasingly capable of deconstructing complex disease processes…”
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Biomarker Development, Commercialization, and Regulation: Individualization of Medicine Lost in Translation
Published in Clinical pharmacology and therapeutics (01-02-2007)Get full text
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Advancing Pharmacometrics and Systems Pharmacology
Published in Clinical pharmacology and therapeutics (01-11-2012)“…Pharmacometrics and systems pharmacology are emerging as principal quantitative sciences within drug development and experimental therapeutics. In recognition…”
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Bacterial Enterotoxins Are Associated with Resistance to Colon Cancer
Published in Proceedings of the National Academy of Sciences - PNAS (04-03-2003)“…One half million patients suffer from colorectal cancer in industrialized nations, yet this disease exhibits a low incidence in underdeveloped countries. This…”
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Guanylyl Cyclase C Agonists Regulate Progression through the Cell Cycle of Human Colon Carcinoma Cells
Published in Proceedings of the National Academy of Sciences - PNAS (03-07-2001)“…The effects of Escherichia coli heat-stable enterotoxin (ST) and uroguanylin were examined on the proliferation of T84 and Caco2 human colon carcinoma cells…”
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Guanylyl Cyclase Is an ATP Sensor Coupling Nitric Oxide Signaling to Cell Metabolism
Published in Proceedings of the National Academy of Sciences - PNAS (06-01-2004)“…Defending cellular integrity against disturbances in intracellular concentrations of ATP ([ ATP]i) is predicated on coordinating the selection of substrates…”
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Therapeutic Targeting: A Crucible for Individualized Medicine
Published in Clinical pharmacology and therapeutics (01-05-2008)Get full text
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Cancer Mucosa Antigens as a Novel Immunotherapeutic Class of Tumor-associated Antigen
Published in Clinical pharmacology and therapeutics (01-12-2007)“…Colorectal cancer is a leading cause of cancer‐related mortality worldwide. Surgery and chemoradiation exhibit incomplete efficacy and, ultimately, 50% of…”
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Guanylyl Cyclase C is a Selective Marker for Metastatic Colorectal Tumors in Human Extraintestinal Tissues
Published in Proceedings of the National Academy of Sciences - PNAS (10-12-1996)“…Guanylyl cyclase C (GCC) has been detected only in intestinal mucosa and colon carcinoma cells of placental mammals. However, this receptor has been identified…”
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Pharmacoeconomics in the Era of Individualized Medicine
Published in Clinical pharmacology and therapeutics (01-08-2008)Get full text
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Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis
Published in Annals of oncology (01-09-2017)“…Distant metastasis accounts for 90% of deaths from colorectal cancer (CRC). Genomic heterogeneity has been reported in various solid malignancies, but remains…”
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Clinical Pharmacology as a Foundation for Translational Science
Published in Clinical pharmacology and therapeutics (01-07-2011)Get full text
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Managing the Innovation Supply Chain to Maximize Personalized Medicine
Published in Clinical pharmacology and therapeutics (01-02-2014)“…Personalized medicine epitomizes an evolving model of care tailored to the individual patient. This emerging paradigm harnesses radical technological advances…”
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