Search Results - "Waldauer, Steven A"

Kinetic response of a photoperturbed allosteric protein by Buchli, Brigitte, Waldauer, Steven A., Walser, Reto, Donten, Mateusz L., Pfister, Rolf, Blöchliger, Nicolas, Steiner, Sandra, Caflisch, Amedeo, Zerbe, Oliver, Hamm, Peter

“…By covalently linking an azobenzene photoswitch across the binding groove of a PDZ domain, a conformational transition, similar to the one occurring upon…”
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Slow Unfolded-State Structuring in Acyl-CoA Binding Protein Folding Revealed by Simulation and Experiment by Voelz, Vincent A, Jäger, Marcus, Yao, Shuhuai, Chen, Yujie, Zhu, Li, Waldauer, Steven A, Bowman, Gregory R, Friedrichs, Mark, Bakajin, Olgica, Lapidus, Lisa J, Weiss, Shimon, Pande, Vijay S

“…Protein folding is a fundamental process in biology, key to understanding many human diseases. Experimentally, proteins often appear to fold via simple two- or…”
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Extremely slow intramolecular diffusion in unfolded protein L by Waldauer, Steven A., Bakajin, Olgica, Lapidus, Lisa J., Baker, David

“…A crucial parameter in many theories of protein folding is the rate of diffusion over the energy landscape. Using a microfluidic mixer we have observed the…”
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Fast infrared spectroscopy of protein dynamics: advancing sensitivity and selectivity by Koziol, Klemens L, Johnson, Philip JM, Stucki-Buchli, Brigitte, Waldauer, Steven A, Hamm, Peter

“…•The untapped potential of 2D-IR spectroscopy lies in its high direct time resolution.•The major limitation of 2D-IR spectroscopy for larger proteins is…”
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Effect of viscogens on the kinetic response of a photoperturbed allosteric protein by Waldauer, Steven A, Stucki-Buchli, Brigitte, Frey, Lukas, Hamm, Peter

“…By covalently binding a photoswitchable linker across the binding groove of the PDZ2 domain, a small conformational change can be photo-initiated that mimics…”
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Photocontrol of Reversible Amyloid Formation with a Minimal-Design Peptide by Waldauer, Steven A, Hassan, Shabir, Paoli, Beatrice, Donaldson, Paul M, Pfister, Rolf, Hamm, Peter, Caflisch, Amedeo, Pellarin, Riccardo

“…Amyloid aggregates are highly ordered fibrillar assemblies of polypeptides involved in a number of neurodegenerative diseases. Very little is known on the…”
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Direct Observation of Downhill Folding of λ-Repressor in a Microfluidic Mixer by DeCamp, Stephen J., Naganathan, Athi N., Waldauer, Steven A., Bakajin, Olgica, Lapidus, Lisa J.

“…The protein λ 6-85 has been implicated in barrierless folding by observations of kinetic relaxation after nanosecond T-jump. In this work we observed folding…”
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Ligand Binding Studied by 2D IR Spectroscopy Using the Azidohomoalanine Label by Bloem, Elin, Koziol, Klemens, Waldauer, Steven A., Buchli, Brigitte, Walser, Reto, Samatanga, Brighton, Jelesarov, Ilian, Hamm, Peter

“…We explore the capability of the azidohomoalanine (Aha) as a vibrational label for 2D IR spectroscopy to study the binding of the target peptide to the PDZ2…”
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Microfluidic mixers for studying protein folding by Waldauer, Steven A, Wu, Ling, Yao, Shuhuai, Bakajin, Olgica, Lapidus, Lisa J

“…The process by which a protein folds into its native conformation is highly relevant to biology and human health yet still poorly understood. One reason for…”
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Exploring the Folding Landscape of Lambda Repressor with Microfluidic Mixing by DeCamp, Stephen, Waldauer, Steven A., Lapidus, Lisa J.

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Measuring Intramolecular Diffusion During Protein Folding Using an Ultrarapid Microfluidic Mixer by Waldauer, Steven A., Kane, Avinash, Bakajin, Olgica, Lapidus, Lisa

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Ruggedness in the folding landscape of protein L by Waldauer, Steven A., Bakajin, Olgica, Ball, Terry, Chen, Yujie, DeCamp, Stephen J., Kopka, Michaela, Jäger, Marcus, Singh, Vijay R., Wedemeyer, William J., Weiss, Shimon, Yao, Shuhuai, Lapidus, Lisa J.

“…By exploring the folding pathways of the B1 domain of protein L with a series of equilibrium and rapid kinetic experiments, we have found its unfolded state to…”
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Circular Dichroism Measurements in a Microfluidic Serpentine Mixer by DeCamp, Stephen J., Waldauer, Steven A., Bakajin, Olgica, Lapidus, Lisa J.

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Slow unfolded-state structuring in ACBP folding revealed by simulation and experiment by Voelz, Vincent A., Jäger, Marcus, Yao, Shuhuai, Chen, Yujie, Zhu, Li, Waldauer, Steven A., Bowman, Gregory R., Friedrichs, Mark, Bakajin, Olgica, Lapidus, Lisa J., Weiss, Shimon, Pande, Vijay S.

“…Protein folding is a fundamental process in biology, key to understanding many human diseases. Experimentally, proteins often appear to fold via simple two- or…”
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Direct Observation of Downhill Folding of [lamda]-Repressor in a Microfluidic Mixer by DeCamp, Stephen J, Naganathan, Athi N, Waldauer, Steven A, Bakajin, Olgica, Lapidus, Lisa J

“…The protein λ(6-85) has been implicated in barrierless folding by observations of kinetic relaxation after nanosecond T-jump. In this work we observed folding…”
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Connecting Unfolded Protein Dynamics and Aggregation by Lapidus, Lisa J., Chen, Yujie, Singh, Vijay R., Waldauer, Steven A., Buscarino, Eric, Voelz, Vince A., Pande, Vijay S.

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Microfluidic Mixers for Studying Protein Folding by Waldauer, Steven A., Wu, Ling, Yao, Shuhuai, Bakajin, Olgica, Lapidus, Lisa J.

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