Search Results - "Walczyński, Krzysztof"

Guanidine Derivatives: How Simple Structural Modification of Histamine H3R Antagonists Has Led to the Discovery of Potent Muscarinic M2R/M4R Antagonists by Staszewski, Marek, Nelic, Dominik, Jończyk, Jakub, Dubiel, Mariam, Frank, Annika, Stark, Holger, Bajda, Marek, Jakubik, Jan, Walczyński, Krzysztof

“…This article describes the discovery of novel potent muscarinic receptor antagonists identified during a search for more active histamine H3 receptor (H3R)…”
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Synthesis and Biological Evaluation of Thiazole-Based Derivatives with Potential against Breast Cancer and Antimicrobial Agents by Pivovarova, Ekaterina, Climova, Alina, Świątkowski, Marcin, Staszewski, Marek, Walczyński, Krzysztof, Dzięgielewski, Marek, Bauer, Marta, Kamysz, Wojciech, Krześlak, Anna, Jóźwiak, Paweł, Czylkowska, Agnieszka

“…Investigating novel, biologically-active coordination compounds that may be useful in the design of breast anticancer, antifungal, and antimicrobial agents is…”
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Metal-based compounds: Synthesis and characterization of new thiazole-based iridium and palladium complexes with potential anticancer and other biological activities by Pivovarova, Ekaterina, Climova, Alina, Świątkowski, Marcin, Dzięgielewski, Marek, Walczyński, Krzysztof, Staszewski, Marek, Gas, Katarzyna, Sawicki, Maciej, Korona-Głowniak, Izabela, Korga-Plewko, Agnieszka, Iwan, Magdalena, Steksova, Yulia, Czylkowska, Agnieszka

“…Six new Pd(II) and Ir(III) thiazole-based complexes were synthesized and characterized by EA, ICP, FTIR, TGA-MS and SEM-EDX. In order to evaluate the…”
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4‑Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H3 Receptors and Cholinesterases by Michalska, Beata, Dzięgielewski, Marek, Godyń, Justyna, Werner, Tobias, Bajda, Marek, Karcz, Tadeusz, Szczepańska, Katarzyna, Stark, Holger, Więckowska, Anna, Walczyński, Krzysztof, Staszewski, Marek

“…This study examines the properties of a novel series of 4-oxypiperidines designed and synthesized as histamine H3R antagonists/inverse agonists based on the…”
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Structures 4-n-propyl Piperazines as Non-Imidazole Histamine H3 Antagonists by Olczak, Andrzej, Sukiennik, Jarosław, Olszewska, Beata, Stefaniak, Monika, Walczyński, Krzysztof, Szczesio, Małgorzata

“…Seven new low-temperature structures of 4-n-propylpiperazine derivatives, potential H3 receptor antagonists, have been determined by X-ray crystallography,…”
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Guanidines: Synthesis of Novel Histamine H3R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect by Staszewski, Marek, Iwan, Magdalena, Werner, Tobias, Bajda, Marek, Godyń, Justyna, Latacz, Gniewomir, Korga-Plewko, Agnieszka, Kubik, Joanna, Szałaj, Natalia, Stark, Holger, Malawska, Barbara, Więckowska, Anna, Walczyński, Krzysztof

“…This study examines the properties of novel guanidines, designed and synthesized as histamine H3R antagonists/inverse agonists with additional pharmacological…”
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Non-Imidazole Histamine H₃ Ligands. Part VII. Synthesis, In Vitro and In Vivo Characterization of 5-Substituted-2-thiazol-4-n-propylpiperazines by Guryn, Roman, Staszewski, Marek, Stasiak, Anna, McNaught Flores, Daniel, Fogel, Wiesława Agnieszka, Leurs, Rob, Walczyński, Krzysztof

“…H₃ receptors present on histaminergic and non-histaminergic neurons, act as autoreceptors or heteroreceptors controlling neurotransmitter release and…”
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Structure–Activity Relationships of New 1‐substitutedmethyl‐4‐[5‐( N ‐methyl‐ N ‐propylamino)pentyloxy]piperidines and Selected 1‐[( N ‐substituted‐ N‐ methyl)‐3‐propyloxy]‐5‐( N ‐methy‐l‐ N ‐propyl)‐pentanediamines as H 3 ‐Antagonists by Masłowska‐Lipowicz, Iwona, Walczyński, Krzysztof

“…Novel, potent non‐imidazole histamine H 3 receptor antagonists have been prepared and in vitro tested as H 3 ‐receptor antagonists (the electrically evoked…”
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Search for multifunctional agents against Alzheimer’s disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives by Jończyk, Jakub, Lodarski, Krzysztof, Staszewski, Marek, Godyń, Justyna, Zaręba, Paula, Soukup, Ondrej, Janockova, Jana, Korabecny, Jan, Sałat, Kinga, Malikowska-Racia, Natalia, Hebda, Michalina, Szałaj, Natalia, Filipek, Barbara, Walczyński, Krzysztof, Malawska, Barbara, Bajda, Marek

“…[Display omitted] •Cholinesterase inhibition ability of fifty histamine H3 receptor ligands was assessed in vitro.•Four promising multi-target-directed ligands…”
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Loratadine analogues as MAGL inhibitors by Patel, Jayendra Z., Ahenkorah, Stephen, Vaara, Miia, Staszewski, Marek, Adams, Yahaya, Laitinen, Tuomo, Navia-Paldanius, Dina, Parkkari, Teija, Savinainen, Juha R., Walczyński, Krzysztof, Laitinen, Jarmo T., Nevalainen, Tapio J.

“…[Display omitted] Compound 12a (JZP-361) acted as a potent and reversible inhibitor of human recombinant MAGL (hMAGL, IC50=46nM), and was found to have almost…”
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Synthesis and Preliminary Pharmacological Investigation of New N-Substituted-N-[ω-(ω-phenoxy-alkylpiperazin-1-yl)alkyl]guanidines as Non-Imidazole Histamine H3 Antagonists by Staszewski, Marek, Walczyński, Krzysztof

“…Novel, potent non‐imidazole histamine H3 receptor antagonists were prepared. Detailed structure–activity studies revealed that…”
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4-Hydroxypiperidines and Their Flexible 3-(Amino)propyloxy Analogues as Non-Imidazole Histamine H₃ Receptor Antagonist: Further Structure⁻Activity Relationship Exploration and In Vitro and In Vivo Pharmacological Evaluation by Olszewska, Beata, Stasiak, Anna, McNaught Flores, Daniel, Fogel, Wiesława Agnieszka, Leurs, Rob, Walczyński, Krzysztof

“…Presynaptic histamine H₃ receptors (H₃R) act as auto- or heteroreceptors controlling, respectively, the release of histamine and of other neurotransmitters in…”
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Design, synthesis, and in vitro and in vivo characterization of 1-{4-[4-(substituted)piperazin-1-yl]butyl}guanidines and their piperidine analogues as histamine H 3 receptor antagonists by Staszewski, Marek, Stasiak, Anna, Karcz, Tadeusz, McNaught Flores, Daniel, Fogel, Wiesława Agnieszka, Kieć-Kononowicz, Katarzyna, Leurs, Rob, Walczyński, Krzysztof

“…Previously, we have shown that 1-substituted-[4-(7-phenoxyheptylpiperazin-1-yl)butyl]guanidine with electron withdrawing substituents at position 4 in the…”
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Non-imidazole histamine H 3 ligands: part V. synthesis and preliminary pharmacological investigation of 1-[2-thiazol-4-yl- and 1-[2-thiazol-5-yl-(2-aminoethyl)]-4- n -propylpiperazine derivatives by Guryn, Roman, Staszewski, Marek, Walczyński, Krzysztof

“…Series of 1-[2-thiazol-4-yl-(2-aminoethyl)]- and 1-[2-thiazol-5-yl-(2-aminoethyl)]-4- -propylpiperazine derivatives have been prepared and in vitro tested as H…”
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Non-Imidazole Histamine H3 Ligands. Part VI. Synthesis and Preliminary Pharmacological Investigation of Thiazole-Type Histamine H3-Receptor Antagonists with Lacking a Nitrogen Nucleus in the Side Chain by Guryn, Roman, Staszewski, Marek, Kopczacki, Piotr, Walczyski, Krzysztof

“…Antagonists to the H3 receptor are considered to be potential drugs for the treatment of Alzheimer's disease, attention deficit-hyperactive disorder, memory…”
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Novel pseudopolymorph of the active metabolite of perindopril by Bojarska, Joanna, Maniukiewicz, Waldemar, Sieroń, Lesław, Fruziński, Andrzej, Kopczacki, Piotr, Walczyński, Krzysztof, Remko, Milan

“…The dimethyl sulfoxide hemisolvate of perindoprilat [systematic name:…”
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Perindoprilat monohydrate by Bojarska, Joanna, Maniukiewicz, Waldemar, Sieroń, Lesław, Kopczacki, Piotr, Walczyński, Krzysztof, Remko, Milan

“…The title compound [systematic name: (1S)‐2‐((S)‐{1‐[(2S,3aS,7aS)‐2‐carboxyoctahydro‐1H‐indol‐1‐yl]‐1‐oxopropan‐2‐yl}azaniumyl)pentanoate monohydrate],…”
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Virtual Screening Approaches to Identify Promising Multitarget-Directed Ligands for the Treatment of Autism Spectrum Disorder by Jończyk, Jakub, Przybylska, Klaudia, Staszewski, Marek, Godyń, Justyna, Werner, Tobias, Stefaniak-Napieralska, Monika, Stark, Holger, Walczyński, Krzysztof, Bajda, Marek

“…Autism spectrum disorder is a complex neurodevelopmental disorder. The available medical treatment options for autism spectrum disorder are very limited. While…”
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Non-imidazole histamine H3 ligands, Part IV: SAR of 1-[2-thiazol-5-yl-(2-aminoethyl)]-4-n-propylpiperazine derivatives by FRYMARKIEWICZ, Anna, WALCZYNSKI, Krzysztof

“…A series of 1-[[2-thiazol-5-yl-(2-aminoethyl)]-4-n-propyl]piperazine derivatives have been prepared and in vitro tested as H(3)-receptor antagonists (the…”
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Preliminary studies of 1,5-benzoxazepine derivatives as potential histamine H 3 receptor antagonists by Stefaniak-Napieralska, Monika, Walczyński, Krzysztof, Iwan, Magdalena, Korga-Plewko, Agnieszka, Szałaj, Natalia, Więckowska, Anna, Staszewski, Marek

“…Our research aimed to evaluate how the rigidification of the characteristic 3-aminopropyloxy linker by incorporating it into 1,5-benzoxazepines affects the…”
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