Search Results - "Walczak, Michal J"

NMRNet: a deep learning approach to automated peak picking of protein NMR spectra by Klukowski, Piotr, Augoff, Michał, Zięba, Maciej, Drwal, Maciej, Gonczarek, Adam, Walczak, Michał J

“…Abstract Motivation Automated selection of signals in protein NMR spectra, known as peak picking, has been studied for over 20 years, nevertheless existing…”
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Interaction prediction in structure-based virtual screening using deep learning by Gonczarek, Adam, Tomczak, Jakub M., Zaręba, Szymon, Kaczmar, Joanna, Dąbrowski, Piotr, Walczak, Michał J.

“…We introduce a deep learning architecture for structure-based virtual screening that generates fixed-sized fingerprints of proteins and small molecules by…”
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Comparative analysis of biophysical methods for monitoring protein proximity induction in the development of small molecule degraders by Przytulski, Kamil, Glaza, Przemyslaw, Brach, Katarzyna, Sagan, Maria, Statkiewicz, Grzegorz, Klajn, Jan, Walczak, Michal J.

“…Targeted protein degradation relies on inducing proximity between an E3 ubiquitin ligase and a target protein, and subsequent proteasomal degradation of the…”
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Computer vision-based automated peak picking applied to protein NMR spectra by Klukowski, Piotr, Walczak, Michal J, Gonczarek, Adam, Boudet, Julien, Wider, Gerhard

“…A detailed analysis of multidimensional NMR spectra of macromolecules requires the identification of individual resonances (peaks). This task can be tedious…”
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Application of Dirichlet process mixture model to the identification of spin systems in protein NMR spectra by Klukowski, Piotr, Augoff, Michał, Zamorski, Maciej, Gonczarek, Adam, Walczak, Michał J.

“…Analysis of structure, function and interactions of proteins by NMR spectroscopy usually requires the assignment of resonances to the corresponding nuclei in…”
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Posttranslational Modifications of Intact Proteins Detected by NMR Spectroscopy: Application to Glycosylation by Schubert, Mario, Walczak, Michal J., Aebi, Markus, Wider, Gerhard

“…Posttranslational modifications (PTMs) are an integral part of the majority of proteins. The characterization of structure and function of PTMs can be very…”
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Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5 by van Drogen, Frank, Mishra, Ranjan, Rudolf, Fabian, Walczak, Michal J, Lee, Sung Sik, Reiter, Wolfgang, Hegemann, Björn, Pelet, Serge, Dohnal, Ilse, Binolfi, Andres, Yudina, Zinaida, Selenko, Philipp, Wider, Gerhard, Ammerer, Gustav, Peter, Matthias

“…Cells continuously adapt cellular processes by integrating external and internal signals. In yeast, multiple stress signals regulate pheromone signaling to…”
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Targeted protein degradation: You can glue it too by Walczak, Michal J, Petzold, Georg, Thomä, Nicolas H

“…Proteolysis-targeting chimera (PROTACs) are synthetic molecules that recruit neo-substrate proteins to a ubiquitin ligase for ubiquitination and subsequent…”
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Intramolecular Donor Strand Complementation in the E. coli Type 1 Pilus Subunit FimA Explains the Existence of FimA Monomers As Off-Pathway Products of Pilus Assembly That Inhibit Host Cell Apoptosis by Walczak, Michal J., Puorger, Chasper, Glockshuber, Rudi, Wider, Gerhard

“…Type 1 pili are filamentous organelles mediating the attachment of uropathogenic Escherichia coli to epithelial cells of host organisms. The helical pilus rod…”
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The RING Domain of the Scaffold Protein Ste5 Adopts a Molten Globular Character with High Thermal and Chemical Stability by Walczak, Michal J., Samatanga, Brighton, van Drogen, Frank, Peter, Matthias, Jelesarov, Ilian, Wider, Gerhard

“…Ste5 is a scaffold protein that controls the pheromone response of the MAP‐kinase cascade in yeast cells. Upon pheromone stimulation, Ste5 (through its RING‐H2…”
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Posttranslational Modifications of Intact Proteins Detected by NMR Spectroscopy: Application to Glycosylation by Schubert, Mario, Walczak, Michal J., Aebi, Markus, Wider, Gerhard

“…Posttranslational modifications (PTMs) are an integral part of the majority of proteins. The characterization of structure and function of PTMs can be very…”
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The RING Domain of the Scaffold Protein Ste5 Adopts a Molten Globular Character with High Thermal and Chemical Stability by Walczak, Michal J., Samatanga, Brighton, van Drogen, Frank, Peter, Matthias, Jelesarov, Ilian, Wider, Gerhard

“…Ste5 is a scaffold protein that controls the pheromone response of the MAP‐kinase cascade in yeast cells. Upon pheromone stimulation, Ste5 (through its RING‐H2…”
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You can glue it too by Walczak, Michal J, Petzold, Georg, Thomä, Nicolas H

“…Proteolysis-targeting chimera (PROTACs) are synthetic molecules that recruit neo-substrate proteins to a ubiquitin ligase for ubiquitination and subsequent…”
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Gaussian process regression for automated signal tracking in step-wise perturbed Nuclear Magnetic Resonance spectra by Zieba, Maciej, Klukowski, Piotr, Gonczarek, Adam, Nikolaev, Yaroslav, Walczak, Michal J.

“…[Display omitted] •Novel tracking method of signals in NMR spectra.•Modelling trajectories with Gaussian process regression model.•First time supervised…”
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A benchmark for automated peak picking of protein NMR spectra by Klukowski, Piotr, Gonczarek, Adam, Walczak, Michal J.

“…In drug discovery field, one of the major used techniques is Nuclear Magnetic Resonance spectroscopy (NMR). To date, most of the steps in NMR analysis have…”
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Learning Deep Architectures for Interaction Prediction in Structure-based Virtual Screening by Gonczarek, Adam, Tomczak, Jakub M, Zaręba, Szymon, Kaczmar, Joanna, Dąbrowski, Piotr, Walczak, Michał J

“…We introduce a deep learning architecture for structure-based virtual screening that generates fixed-sized fingerprints of proteins and small molecules by…”
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