Search Results - "Walczak, E."

Microtubule-Depolymerizing Kinesins by Walczak, Claire E, Gayek, Sophia, Ohi, Ryoma

“…The microtubule (MT) cytoskeleton supports a broad range of cellular functions, from providing tracks for intracellular transport, to supporting movement of…”
Get full text

Kif18A Uses a Microtubule Binding Site in the Tail for Plus-End Localization and Spindle Length Regulation by Weaver, Lesley N., Ems-McClung, Stephanie C., Stout, Jane R., LeBlanc, Chantal, Shaw, Sidney L., Gardner, Melissa K., Walczak, Claire E.

“…The mitotic spindle is a macromolecular structure utilized to properly align and segregate sister chromatids to two daughter cells. During mitosis, the spindle…”
Get full text

Kinesin-13s in mitosis: Key players in the spatial and temporal organization of spindle microtubules by Ems-McClung, Stephanie C., Walczak, Claire E.

“…Dynamic microtubules are essential for the process of mitosis. Thus, elucidating when, where, and how microtubule dynamics are regulated is key to…”
Get full text

Quantifying the differential functional behavior between the medial and lateral meniscus after posterior meniscus root tears by Walczak, Brian E, Miller, Kyle, Behun, Michael A, Sienkiewicz, Lisa, Hartwig Stokes, Heather, McCabe, Ron, Baer, Geoffrey S

“…Meniscus tears of the knee are among the most common orthopedic knee injury. Specifically, tears of the posterior root can result in abnormal meniscal…”
Get full text

Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules by Cai, Shang, Weaver, Lesley N, Ems-McClung, Stephanie C, Walczak, Claire E

“…Kinesin-14 family proteins are minus-end directed motors that cross-link microtubules and play key roles during spindle assembly. We showed previously that the…”
Get full text

Canine ACL rupture: a spontaneous large animal model of human ACL rupture by Binversie, Emily E, Walczak, Brian E, Cone, Stephanie G, Baker, Lauren A, Scerpella, Tamara A, Muir, Peter

“…Anterior cruciate ligament (ACL) rupture in humans is a common condition associated with knee pain, joint instability, and secondary osteoarthritis (OA)…”
Get full text

A Cyclin A-Myb-MuvB-Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cycles by Rotelli, Michael D, Policastro, Robert A, Bolling, Anna M, Killion, Andrew W, Weinberg, Abraham J, Dixon, Michael J, Zentner, Gabriel E, Walczak, Claire E, Lilly, Mary A, Calvi, Brian R

“…Endoreplication is a cell cycle variant that entails cell growth and periodic genome duplication without cell division, and results in large, polyploid cells…”
Get full text

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity by Zhang, Xin, Ems-McClung, Stephanie C, Walczak, Claire E

“…During mitosis, mitotic centromere-associated kinesin (MCAK) localizes to chromatin/kinetochores, a cytoplasmic pool, and spindle poles. Its localization and…”
Get full text

Aurora B Inhibits MCAK Activity through a Phosphoconformational Switch that Reduces Microtubule Association by Ems-McClung, Stephanie C., Hainline, Sarah G., Devare, Jenna, Zong, Hailing, Cai, Shang, Carnes, Stephanie K., Shaw, Sidney L., Walczak, Claire E.

“…Proper spindle assembly and chromosome segregation rely on precise microtubule dynamics, which are governed in part by the kinesin-13 MCAK. MCAK microtubule…”
Get full text

A Standardized Kinesin Nomenclature by Lawrence, Carolyn J., Dawe, R. Kelly, Christie, Karen R., Cleveland, Don W., Dawson, Scott C., Endow, Sharyn A., Lawrence S. B. Goldstein, Goodson, Holly V., Hirokawa, Nobutaka, Howard, Jonathon, Malmberg, Russell L., McIntosh, J. Richard, Miki, Harukata, Mitchison, Timothy J., Okada, Yasushi, Anireddy S. N. Reddy, Saxton, William M., Schliwa, Manfred, Scholey, Jonathan M., Vale, Ronald D., Walczak, Claire E., Wordeman, Linda

“…In recent years the kinesin superfamily has become so large that several different naming schemes have emerged, leading to confusion and miscommunication…”
Get full text

Computer-Generated R.E.N.A.L. Nephrometry Scores Yield Comparable Predictive Results to Those of Human-Expert Scores in Predicting Oncologic and Perioperative Outcomes by Heller, N, Tejpaul, R, Isensee, F, Benidir, T, Hofmann, M, Blake, P, Rengal, Z, Moore, K, Sathianathen, N, Kalapara, A, Rosenberg, J, Peterson, S, Walczak, E, Kutikov, A, Uzzo, R G, Palacios, D A, Remer, E M, Campbell, S C, Papanikolopoulos, N, Weight, Christopher J

“…We sought to automate R.E.N.A.L. (for radius, exophytic/endophytic, nearness of tumor to collecting system, anterior/posterior, location relative to polar…”
Get full text

The Ran-GTP Gradient Spatially Regulates XCTK2 in the Spindle by Weaver, Lesley N., Ems-McClung, Stephanie C., Chen, Sez-Hon R., Yang, Ge, Shaw, Sidney L., Walczak, Claire E.

“…Ran is a small GTP binding protein that was originally identified as a regulator of nucleocytoplasmic transport [1] and subsequently found to be important for…”
Get full text

Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments by Kline-Smith, Susan L, Khodjakov, Alexey, Hergert, Polla, Walczak, Claire E

“…The complex behavior of chromosomes during mitosis is accomplished by precise binding and highly regulated polymerization dynamics of kinetochore microtubules…”
Get full text

Sarcoma Chemotherapy by Walczak, Brian E, Irwin, Ronald B

“…Sarcomas are a rare, heterogeneous group of malignant tumors of the bone or soft tissue. Although historically intended for the pharmaceutical treatment of…”
Get full text

Microtubule dynamics and tubulin interacting proteins by Walczak, Claire E

“…Microtubule dynamics are crucial in generation of the mitotic spindle. During the transition from interphase to mitosis, there is an increase in the frequency…”
Get full text

Spatial gradients controlling spindle assembly by Weaver, Lesley N, Walczak, Claire E

“…The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key…”
Get more information

Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function by Zhang, Xin, Lan, Weijie, Ems-McClung, Stephanie C, Stukenberg, P Todd, Walczak, Claire E

“…Chromosome congression and segregation require the proper attachment of microtubules to the two sister kinetochores. Disruption of either Aurora B kinase or…”
Get full text

Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity by Lan, Weijie, Zhang, Xin, Kline-Smith, Susan L, Rosasco, Sara E, Barrett-Wilt, Gregory A, Shabanowitz, Jeffrey, Hunt, Donald F, Walczak, Claire E, Stukenberg, P.Todd

“…Background: Sister kinetochores must bind microtubules in a bipolar fashion to equally segregate chromosomes during mitosis. The molecular mechanisms…”
Get full text

Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase by Sharp, David J, Rogers, Gregory C, Rogers, Stephen L, Schwimmer, Tamara A, Ems-McClung, Stephanie C, Walczak, Claire E, Vale, Ronald D, Scholey, Jonathan M

“…During anaphase identical sister chromatids separate and move towards opposite poles of the mitotic spindle. In the spindle, kinetochore microtubules have…”
Get full text

Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors by Borysov, Sergiy I., Granic, Antoneta, Padmanabhan, Jaya, Walczak, Claire E., Potter, Huntington

“…Chromosome mis-segregation and aneuploidy are greatly induced in Alzheimer's disease and models thereof by mutant forms of the APP and PS proteins and by their…”
Get full text