Search Results - "Walavalkar, Ninad M."

Identification of breast cancer associated variants that modulate transcription factor binding by Liu, Yunxian, Walavalkar, Ninad M, Dozmorov, Mikhail G, Rich, Stephen S, Civelek, Mete, Guertin, Michael J

“…Genome-wide association studies (GWAS) have discovered thousands loci associated with disease risk and quantitative traits, yet most of the variants…”
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Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA by Cramer, Jason M, Scarsdale, J Neel, Walavalkar, Ninad M, Buchwald, William A, Ginder, Gordon D, Williams, Jr, David C

“…Although highly homologous to other methylcytosine-binding domain (MBD) proteins, MBD3 does not selectively bind methylated DNA, and thus the functional role…”
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Unique Features of the Anti-parallel, Heterodimeric Coiled-coil Interaction between Methyl-cytosine Binding Domain 2 (MBD2) Homologues and GATA Zinc Finger Domain Containing 2A (GATAD2A/p66α) by Walavalkar, Ninad M., Gordon, Nathaniel, Williams, David C.

“…The methyl-cytosine binding domain 2 (MBD2)-nucleosome remodeling and deacetylase (NuRD) complex recognizes methylated DNA and silences expression of…”
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p66α—MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2—NuRD complex by Gnanapragasam, Merlin Nithya, Scarsdale, J. Neel, Amaya, Maria L., Webb, Heather D., Desai, Megha A., Walavalkar, Ninad M., Wang, Shou Zhen, Zu Zhu, Sheng, Ginder, Gordon D., Williams, David C., Felsenfeld, Gary

“…Nucleosome remodeling complexes comprise several large families of chromatin modifiers that integrate multiple epigenetic control signals to play key roles in…”
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Methylation specific targeting of a chromatin remodeling complex from sponges to humans by Cramer, Jason M., Pohlmann, Deborah, Gomez, Fernando, Mark, Leslie, Kornegay, Benjamin, Hall, Chelsea, Siraliev-Perez, Edhriz, Walavalkar, Ninad M., Sperlazza, M. Jeannette, Bilinovich, Stephanie, Prokop, Jeremy W., Hill, April L., Williams Jr, David C.

“…DNA cytosine methylation and methyl-cytosine binding domain (MBD) containing proteins are found throughout all vertebrate species studied to date. However,…”
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Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches by Walavalkar, Ninad M, Cramer, Jason M, Buchwald, William A, Scarsdale, J Neel, Williams, Jr, David C

“…Unlike other members of the methyl-cytosine binding domain (MBD) family, MBD4 serves as a potent DNA glycosylase in DNA mismatch repair specifically targeting…”
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Universal correction of enzymatic sequence bias reveals molecular signatures of protein/DNA interactions by Martins, André L, Walavalkar, Ninad M, Anderson, Warren D, Zang, Chongzhi, Guertin, Michael J

“…Abstract Coupling molecular biology to high-throughput sequencing has revolutionized the study of biology. Molecular genomics techniques are continually…”
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Kinetic networks identify TWIST2 as a key regulatory node in adipogenesis by Dutta, Arun B, Lank, Daniel S, Przanowska, Roza K, Przanowski, Piotr, Wang, Lixin, Nguyen, Bao, Walavalkar, Ninad M, Duarte, Fabiana M, Guertin, Michael J

“…Adipocytes contribute to metabolic disorders such as obesity, diabetes, and atherosclerosis. Prior characterizations of the transcriptional network driving…”
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An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex by Desai, Megha A, Webb, Heather D, Sinanan, Leander M, Scarsdale, J Neel, Walavalkar, Ninad M, Ginder, Gordon D, Williams, Jr, David C

“…The MBD2-NuRD (Nucleosome Remodeling and Deacetylase) complex is an epigenetic reader of DNA methylation that regulates genes involved in normal development…”
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Dissecting the structural basis of MEIG1 interaction with PACRG by Li, Wei, Walavalkar, Ninad M., Buchwald, William A., Teves, Maria E., Zhang, Ling, Liu, Hong, Bilinovich, Stephanie, Peterson, Darrell L., Strauss III, Jerome F., Williams Jr, David C., Zhang, Zhibing

“…The product of the meiosis-expressed gene 1 (MEIG1) is found in the cell bodies of spermatocytes and recruited to the manchette, a structure unique to…”
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Probing the Dynamic Distribution of Bound States for Methylcytosine-binding Domains on DNAThis work was supported, in whole or in part, by National Institutes of Health Grants R01 GM098624 (to D. C. W.) and R01 DK029902 (to G. D. G.). NMR data were acquired using NMR instrumentation in the Virginia Commonwealth University Massey Cancer Center Structural Biology Core, and surface plasmon resonance data were acquired in the Virginia Commonwealth University Massey Cancer Center Flow Cytometry Core, by Cramer, Jason M., Scarsdale, J. Neel, Walavalkar, Ninad M., Buchwald, William A., Ginder, Gordon D., Williams, David C.

“…Although highly homologous to other methylcytosine-binding domain (MBD) proteins, MBD3 does not selectively bind methylated DNA, and thus the functional role…”
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An intrinsically unstructured domain in MBD2 recruits the histone deacetylase core complex of NuRD and modifies kinetics of DNA binding by Williams, David C, Desai, Megha, Ginder, Gordon D, Walavalkar, Ninad M

“…Abstract only MBD2 specifically recognizes methylated DNA and recruits the NuRD chromatin remodeling complex to silence expression of the associated gene. We…”
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p66[alpha]-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex by Gnanapragasam, Merlin Nithya, Scarsdale, J Neel, Amaya, Maria L, Webb, Heather D, Desai, Megha A, Walavalkar, Ninad M, Wang, Shou Zhen, Zhu, Sheng Zu, Ginder, Gordon D, Williams, David C

“…Nucleosome remodeling complexes comprise several large families of chromatin modifiers that integrate multiple epigenetic control signals to play key roles in…”
Get full text

p66α-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex by Gnanapragasam, Merlin Nithya, Scarsdale, J. Neel, Amaya, Maria L, Webb, Heather D, Desai, Megha A, Walavalkar, Ninad M, Wang, Shou Zhen, Zu Zhu, Sheng, Ginder, Gordon D, Williams, David C. Jr

“…Nucleosome remodeling complexes comprise several large families of chromatin modifiers that integrate multiple epigenetic control signals to play key roles in…”
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p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex by Gnanapragasam, Merlin Nithya, Scarsdale, J Neel, Amaya, Maria L, Webb, Heather D, Desai, Megha A, Walavalkar, Ninad M, Wang, Shou Zhen, Zu Zhu, Sheng, Ginder, Gordon D, Williams, Jr, David C

“…Nucleosome remodeling complexes comprise several large families of chromatin modifiers that integrate multiple epigenetic control signals to play key roles in…”
Get full text