Search Results - "Wakitani, Korekiyo"

Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain–hypothalamic neural pathways in rats by Ogawa, Nobuya, Ito, Makoto, Yamaguchi, Hideki, Shiuchi, Tetsuya, Okamoto, Shiki, Wakitani, Korekiyo, Minokoshi, Yasuhiko, Nakazato, Masamitsu

“…Abstract The intestine plays important roles in the regulation of feeding behavior by sensing macronutrients. Intestinal fatty acids strongly suppress food…”
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Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice by Ueda, Yoshifumi, Miyagawa, Naoki, Wakitani, Korekiyo

“…Involvement of cannabinoid CB2 receptors in the IgE-mediated cutaneous reaction was investigated. Epicutaneous challenge with 2,4-dinitrofluorobenzene caused a…”
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Two Pharmacological Phases in Antigen-Induced Immediate Airway Response in Rats by Miyagawa, Naoki, Iwasaki, Hidenori, Kato, Toshinobu, Tanaka, Masaru, Shibata, Tsutomu, Wakitani, Korekiyo

“…The pharmacological profiles of antigen-induced immediate airway response (IAR) in rats are not fully understood. In this study, we established an ovalbumin…”
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Pharmacological Analysis of Antigen-Induced Late Airway Response in Rats by Miyagawa, Naoki, Iwasaki, Hidenori, Kato, Toshinobu, Tanaka, Masaru, Shibata, Tsutomu, Wakitani, Korekiyo

“…The pharmacological and pathophysiological characteristics of rat antigen-induced late airway response (LAR) are not yet fully understood. In this study, the…”
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Comparative study of glucocorticoids, cyclosporine A, and JTE-607 [(-)-Ethyl-N[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride] in a mouse septic shock model by Iwamura, Hiroyuki, Sato, Motohide, Wakitani, Korekiyo

“…Actions of glucocorticoids, cyclosporine A, and JTE-607 [(-)-ethyl-N-[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate…”
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Induction of late airway response was involved in serum antigen-specific immunoglobulin G in rats by Miyagawa, Naoki, Iwasaki, Hidenori, Kato, Toshinobu, Tanaka, Masaru, Shibata, Tsutomu, Wakitani, Korekiyo

“…The antigen-induced immediate airway response (IAR) has been considered a form of bronchoconstriction mainly provoked by histamine and leukotriene C 4/D 4/E 4,…”
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Synthesis and Structure−Activity Relationships of 5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepine Derivatives:  Novel Arginine Vasopressin Antagonists by Cho, Hidetsura, Murakami, Kengo, Nakanishi, Hiroyuki, Fujisawa, Akitaka, Isoshima, Hirotaka, Niwa, Misako, Hayakawa, Kazuhide, Hase, Yasunori, Uchida, Itsuo, Watanabe, Hidenori, Wakitani, Korekiyo, Aisaka, Kazuo

“…A variety of novel heterocyclic compounds having thienoazepine, pyrroloazepine, furoazepine, and thienodiazepine skeletons were synthesized, most of which…”
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Inhibitory effect of JTV-803, a new cyclic guanidine derivative, on factor Xa in vitro and in vivo by Hayashi, Mikio, Hamada, Atsushi, Okaya, Yuki, Wakitani, Korekiyo, Aisaka, Kazuo

“…JTV-803, 4-[(2-amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-1-(4-pyridinyl)piperidine-4-carboxylic acid monomethanesulfonate trihydrate showed a…”
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JTT-608 controls blood glucose by enhancement of glucose-stimulated insulin secretion in normal and diabetes mellitus rats by Ohta, Takeshi, Furukawa, Noboru, Yonemori, Fumihiko, Wakitani, Korekiyo

“…We investigated the pharmacological effects of a new anti-hyperglycemic agent, JTT-608 [ trans-4-(4-methylcyclohexyl)-4-oxobutyric acid], in normal and…”
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JTT‐501, a novel oral antidiabetic agent, improves insulin resistance in genetic and non‐genetic insulin‐resistant models by Shibata, Tsutomu, Matsui, Kenichi, Yonemori, Fumihiko, Wakitani, Korekiyo

“…We investigated whether JTT‐501 (4‐[4‐[2‐(5‐methyl‐2‐phenyl‐4‐oxazolyl)ethoxy]benzyl]‐3,5‐isoxazolidinedione) would improve insulin resistance in genetic…”
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JTT‐608 restores impaired early insulin secretion in diabetic Goto‐Kakizaki rats by Ohta, Takeshi, Furukawa, Noboru, Komuro, Goro, Yonemori, Fumihiko, Wakitani, Korekiyo

“…We investigated the pharmacological effects of a new antidiabetic agent, JTT‐608, in comparison with the sulphonylurea tolbutamide, in Goto‐Kakizaki (GK) rats,…”
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A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits by Okamoto, Hiroshi, Yonemori, Fumihiko, Wakitani, Korekiyo, Minowa, Takashi, Maeda, Kimiya, Shinkai, Hisashi

“…Cholesteryl ester transfer protein (CETP) is a plasma protein that mediates the exchange of cholesteryl ester in high-density lipoprotein (HDL) for…”
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4-(4-Cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as Selective Cyclooxygenase-2 Inhibitors:  Enhancement of the Selectivity by Introduction of a Fluorine Atom and Identification of a Potent, Highly Selective, and Orally Active COX-2 Inhibitor JTE-522 by Hashimoto, Hiromasa, Imamura, Katsuaki, Haruta, Jun-ichi, Wakitani, Korekiyo

“…A series of 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamide derivatives were synthesized and evaluated for their abilities to inhibit cyclooxygenase-2…”
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Involvement of cannabinoid CB 2 receptors in the IgE-mediated triphasic cutaneous reaction in mice by Ueda, Yoshifumi, Miyagawa, Naoki, Wakitani, Korekiyo

“…Involvement of cannabinoid CB 2 receptors in the IgE-mediated cutaneous reaction was investigated. Epicutaneous challenge with 2,4-dinitrofluorobenzene caused…”
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Effects of ONO-3708, an antagonist of the thromboxane A2/prostaglandin endoperoxide receptor, on platelet aggregation and thrombosis by Kondo, K, Seo, R, Naka, M, Kitagawa, T, Wakitani, K, Sakata, M, Kira, H, Okegawa, T, Kawasaki, A

“…The beneficial effects of an antagonist of the thromboxane A2/prostaglandin endoperoxide receptor, 7-[2 alpha,4 alpha-(dimethylmethano)-6 beta-(2-cyclopentyl-2…”
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Profile of JTE-522 as a Human Cyclooxygenase-2 Inhibitor by Wakitani, Korekiyo, Nanayama, Toyomichi, Masaki, Michiko, Matsushita, Mutsuyoshi

“…Inhibitory activity and the mechanism of action of JTE-522 (4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide), a novel selective cyclooxygenase…”
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Effects of peroxisome proliferator‐activated receptor‐α and ‐γ agonist, JTT‐501, on diabetic complications in Zucker diabetic fatty rats by Shibata, Tsutomu, Takeuchi, Satomi, Yokota, Seiko, Kakimoto, Kochi, Yonemori, Fumihiko, Wakitani, Korekiyo

“…This study has investigated the effects of JTT‐501, a peroxisome proliferator‐activated receptor (PPAR)‐α and PPAR‐γ agonist, on the pathogenesis of diabetic…”
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Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522 by Sasai, H, Masaki, M, Wakitani, K

“…Mutations of the adenomatous polyposis coli gene (Apc) have been implicated in the occurrence of sporadic colon cancer. Various Apc knockout strains of mice…”
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Effect of a prostacyclin analog OP-2507 on acute ischemic cerebral edema in cats by Terawaki, T, Takakuwa, T, Iguchi, S, Wakitani, K, Kira, H, Okegawa, T, Kawasaki, A, Masuda, Y

“…We evaluated the inhibitory activity of a novel prostacyclin analog, OP-2507 (15-cis-(4-n-propylcyclohexyl)-16,17,18,19,20-pentanor-9-deo xy-6,9 alpha-…”
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Effect of JTT-705 on cholesteryl ester transfer protein and plasma lipid levels in normolipidemic animals by Okamoto, Hiroshi, Iwamoto, Yoko, Maki, Mimi, Sotani, Tomohiro, Yonemori, Fumihiko, Wakitani, Korekiyo

“…This study evaluated JTT-705, S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]2-methylpropanethioate, as a cholesteryl ester transfer protein (CETP)…”
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