Search Results - "Wakita, Hideaki"

Effects of exercise and bryostatin-1 on functional recovery and posttranslational modification in the perilesional cortex after cerebral infarction by Mizutani, Kenmei, Sonoda, Shigeru, Wakita, Hideaki, Takahashi, Yu

“…Strokes can cause a variety of sequelae, such as paralysis, particularly in the early stages after stroke onset. Rehabilitation therapy atthis time often…”
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Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome by Matsuyama, Hirofumi, Shindo, Akihiro, Shimada, Takuya, Yata, Kenichiro, Wakita, Hideaki, Takahashi, Ryosuke, Tomimoto, Hidekazu

“…•Cerebral hypoperfusion may induce upregulation of NLRP3, AIM2-inflammasomes.•NLRP3 could have a role in the sterile inflammatory responses in astrocytes, and…”
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Ritanserin, a serotonin-2 receptor antagonist, inhibits functional recovery after cerebral infarction by Mizutani, Kenmei, Sonoda, Shigeru, Wakita, Hideaki

“…It has been suggested that serotonin (5-HT) may be implicated in functional recovery after stroke; however, the underlying molecular mechanisms remain unknown…”
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Stem cells from human exfoliated deciduous tooth-derived conditioned medium enhance recovery of focal cerebral ischemia in rats by Inoue, Takanori, Sugiyama, Masahiko, Hattori, Hisashi, Wakita, Hideaki, Wakabayashi, Toshihiko, Ueda, Minoru

“…Regenerative therapy using stem cells is a promising approach for the treatment of stroke. Recently, we reported that dental pulp stem cells (DPSC) ameliorated…”
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A Novel Stem Cell Source for Vasculogenesis in Ischemia: Subfraction of Side Population Cells from Dental Pulp by Iohara, Koichiro, Zheng, Li, Wake, Hiroaki, Ito, Masataka, Nabekura, Junichi, Wakita, Hideaki, Nakamura, Hiroshi, Into, Takeshi, Matsushita, Kenji, Nakashima, Misako

“…Cell therapy with stem cells and endothelial progenitor cells (EPCs) to stimulate vasculogenesis as a potential treatment for ischemic disease is an exciting…”
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Selective accumulation of adiponectin in the cerebral cortex under chronic cerebral hypoperfusion in the rat by Takahashi, Yu, Wakita, Hideaki, Mizutani, Kenmei, Watanabe, Atsushi, Sonoda, Shigeru, Tomimoto, Hidekazu

“…Adiponectin is a plasma protein predominantly derived from adipocytes. Adiponectin has beneficial properties against diabetes, cardiovascular diseases, and…”
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Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice by Yoshizaki, Kaichi, Adachi, Kayo, Kataoka, Seiko, Watanabe, Atsushi, Tabira, Takeshi, Takahashi, Keikichi, Wakita, Hideaki

“…Some lines of evidence have suggested that subcortical ischemic vascular dementia (SIVD) is a common form of vascular dementia (VaD), and that its pathological…”
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Short-course remdesivir for healthcare-associated COVID-19: Case series from a non-acute care hospital by Takahashi, Yu, Wakita, Hideaki, Ishihara, Takuma, Okazaki, Hideto, Ito, Akihiro, Iwata, Mitsunaga, Sonoda, Shigeru, Doi, Yohei

“…Healthcare-associated COVID-19 among vulnerable patients leads to disproportionate morbidity and mortality. Early pharmacologic intervention may reduce…”
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Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice by Shimada, Takuya, Shindo, Akihiro, Matsuyama, Hirofumi, Yata, Kenichiro, Niwa, Atsushi, Sasaki, Ryogen, Ayaki, Takashi, Maki, Takakuni, Wakita, Hideaki, Tomimoto, Hidekazu

“…•Bilateral common carotid artery stenosis (BCAS) promotes tau phosphorylation.•Astrocytic leptin-R expression is increased via AKT pathway in the BCAS…”
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Effects of Crystallographic Structures of Metal-Phthalocyanine on Electrocatalytic Properties of Oxygen Reduction in Acidic Condition by Takase, Satoko, Aoto, Yuki, Ikeda, Daiki, Wakita, Hideaki, Shimizu, Youichi

“…Effects of the crystallographic structures of metal-phthalocyanines (metal: Co, Ni, Cu, Zn) between α and β phases on electrochemical oxygen reduction…”
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Dental pulp-derived CD31⁻/CD146⁻ side population stem/progenitor cells enhance recovery of focal cerebral ischemia in rats by Sugiyama, Masahiko, Iohara, Koichiro, Wakita, Hideaki, Hattori, Hisashi, Ueda, Minoru, Matsushita, Kenji, Nakashima, Misako

“…Regenerative therapy using stem cells is a promising approach for the treatment of stroke. Recently, we reported that CD31⁻/CD146⁻ side population (SP) cells…”
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Effects of exercise and bryostatin-1 on serotonin dynamics after cerebral infarction by Mizutani, Kenmei, Sonoda, Shigeru, Wakita, Hideaki, Okazaki, Hideto, Katoh, Yoshimitsu, Chihara, Takeshi, Shimpo, Kan

“…Although it has been suggested that the combination of exercise and bryostatin-1 administration may induce greater functional recovery than exercise alone, the…”
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Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells by Lee, Yang-ja, Miyake, Shin-ichi, Wakita, Hideaki, McMullen, David C, Azuma, Yoshiaki, Auh, Sungyoung, Hallenbeck, John M

“…Hibernation torpor provides an excellent natural model of tolerance to profound reductions in blood flow to the brain and other organs. Here, we report that…”
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Hypophosphorylation of ribosomal protein S6 is a molecular mechanism underlying ischemic tolerance induced by either hibernation or preconditioning by Miyake, Shin‐ichi, Wakita, Hideaki, Bernstock, Joshua D., Castri, Paola, Ruetzler, Christl, Miyake, Junko, Lee, Yang‐ja, Hallenbeck, John M.

“…Thirteen‐lined ground squirrels (Ictidomys tridecemlineatus) have an extraordinary capacity to withstand prolonged and profound reductions in blood flow and…”
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Subcortical vascular dementia by Wakita, Hideaki

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A Nationwide Survey and Multicenter Registry-Based Database of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy in Japan by Shindo, Akihiro, Tabei, Ken-Ichi, Taniguchi, Akira, Nozaki, Hiroaki, Onodera, Osamu, Ueda, Akihiko, Ando, Yukio, Urabe, Takao, Kimura, Kazumi, Kitagawa, Kazuo, Hanyu, Haruo, Hirano, Teruyuki, Wakita, Hideaki, Fukuyama, Hidenao, Kagimura, Tatsuo, Miyamoto, Yoshihiro, Takegami, Misa, Saito, Satoshi, Watanabe-Hosomi, Akiko, Mizuta, Ikuko, Ihara, Masafumi, Mizuno, Toshiki, Tomimoto, Hidekazu

“…Clinical characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) include migraine, recurrent…”
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Susceptibility-weighted Imaging Effectively Reveals Small Cavernomas by Kataoka, Seiko, Wakita, Hideaki

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Homocysteine, Another Risk Factor for Alzheimer Disease, Impairs Apolipoprotein E3 Function by Minagawa, Hirohisa, Watanabe, Atsushi, Akatsu, Hiroyasu, Adachi, Kayo, Ohtsuka, Chigumi, Terayama, Yasuo, Hosono, Takashi, Takahashi, Satoshi, Wakita, Hideaki, Jung, Cha-Gyun, Komano, Hiroto, Michikawa, Makoto

“…Apolipoprotein E (apoE) ϵ4 and hyperhomocysteinemia are risk factors for Alzheimer disease (AD). The dimerization of apoE3 by disulfide bonds between cysteine…”
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Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat by Wakita, Hideaki, Tomimoto, Hidekazu, Akiguchi, Ichiro, Matsuo, Akinori, Lin, Jin-Xi, Ihara, Masafumi, McGeer, Patrick-L

“…Cerebral white matter (WM) lesions are observed frequently in human ischemic cerebrovascular disease and have been thought to contribute to cognitive…”
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Blood-Brain Barrier Disruption in White Matter Lesions in a Rat Model of Chronic Cerebral Hypoperfusion by Ueno, Masaki, Tomimoto, Hidekazu, Akiguchi, Ichiro, Wakita, Hideaki, Sakamoto, Haruhiko

“…Blood–brain barrier damage has been implicated in the pathogenesis of cerebrovascular white matter lesions. This type of lesion is responsible for cognitive…”
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