Search Results - "Wakeland, Edward K."

T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells by Jain, Aakanksha, Song, Ran, Wakeland, Edward K., Pasare, Chandrashekhar

“…Innate cytokines are critical drivers of priming and differentiation of naive CD4 T cells, but their functions in memory T cell response are largely undefined…”
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RAD51 interconnects between DNA replication, DNA repair and immunity by Bhattacharya, Souparno, Srinivasan, Kalayarasan, Abdisalaam, Salim, Su, Fengtao, Raj, Prithvi, Dozmorov, Igor, Mishra, Ritu, Wakeland, Edward K, Ghose, Subroto, Mukherjee, Shibani, Asaithamby, Aroumougame

“…RAD51, a multifunctional protein, plays a central role in DNA replication and homologous recombination repair, and is known to be involved in cancer…”
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Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation by Hu, Wei, Jain, Aakanksha, Gao, Yajing, Dozmorov, Igor M., Mandraju, Rajakumar, Wakeland, Edward K., Pasare, Chandrashekhar

“…Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation, a process involving…”
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Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice by Hasan, Maroof, Dobbs, Nicole, Khan, Shaheen, White, Michael A, Wakeland, Edward K, Li, Quan-Zhen, Yan, Nan

“…TANK-binding kinase 1 (TBK1) is a serine/threonine protein kinase that plays a crucial role in innate immunity. Enhanced TBK1 function is associated with…”
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IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility by Song, Ran, Gao, Yajing, Dozmorov, Igor, Malladi, Venkat, Saha, Irene, McDaniel, Margaret M., Parameswaran, Sreeja, Liang, Chaoying, Arana, Carlos, Zhang, Bo, Wakeland, Benjamin, Zhou, Jinchun, Weirauch, Matthew T., Kottyan, Leah C., Wakeland, Edward K., Pasare, Chandrashekhar

“…Myeloid lineage cells use TLRs to recognize and respond to diverse microbial ligands. Although unique transcription factors dictate the outcome of specific TLR…”
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A Tlr7 Translocation Accelerates Systemic Autoimmunity in Murine Lupus by Subramanian, Srividya, Tus, Katalin, Li, Quan-Zhen, Wang, Andrew, Tian, Xiang-Hong, Zhou, Jinchun, Liang, Chaoying, Bartov, Guy, McDaniel, Lisa D., Zhou, Xin J., Schultz, Roger A., Wakeland, Edward K.

“…The y-linked autoimmune accelerating (yaa) locus is a potent autoimmune disease allele. Transcription profiling of yaa-bearing B cells revealed the…”
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Distinct patterns of innate immune activation by clinical isolates of respiratory syncytial virus by Levitz, Ruth, Gao, Yajing, Dozmorov, Igor, Song, Ran, Wakeland, Edward K, Kahn, Jeffrey S

“…Respiratory syncytial virus (RSV) is a major respiratory pathogen of infants and young children. Multiple strains of both subgroup A and B viruses circulate…”
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SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature by Becker, Amy M, Dao, Kathryn H, Han, Bobby Kwanghoon, Kornu, Roger, Lakhanpal, Shuchi, Mobley, Angela B, Li, Quan-Zhen, Lian, Yun, Wu, Tianfu, Reimold, Andreas M, Olsen, Nancy J, Karp, David R, Chowdhury, Fatema Z, Farrar, J David, Satterthwaite, Anne B, Mohan, Chandra, Lipsky, Peter E, Wakeland, Edward K, Davis, Laurie S

“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized by defective immune tolerance combined with immune cell hyperactivity…”
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Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells by Arai, Satoko, Maehara, Natsumi, Iwamura, Yoshihiro, Honda, Shin-ichiro, Nakashima, Katsuhiko, Kai, Toshihiro, Ogishi, Masato, Morita, Kumiko, Kurokawa, Jun, Mori, Mayumi, Motoi, Yuji, Miyake, Kensuke, Matsuhashi, Nobuyuki, Yamamura, Ken-ichi, Ohara, Osamu, Shibuya, Akira, Wakeland, Edward K., Li, Quan-Zhen, Miyazaki, Toru

“…Natural immunoglobulin M (IgM) is reactive to autoantigens and is believed to be important for autoimmunity. Blood pentameric IgM loaded with antigens forms a…”
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Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements by Zhu, Lingxiang, Yan, Zhongqiang, Zhang, Zhaojun, Zhou, Qiming, Zhou, Jinchun, Wakeland, Edward K, Fang, Xiangdong, Xuan, Zhenyu, Shen, Dingxia, Li, Quan-Zhen

“…The emergence and rapid spreading of multidrug-resistant Acinetobacter baumannii strains has become a major health threat worldwide. To better understand the…”
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B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice by Hwang, Sun-Hee, Lee, Huiyin, Yamamoto, Miwako, Jones, Leigh A, Dayalan, Jivanaah, Hopkins, Richard, Zhou, Xin J, Yarovinsky, Felix, Connolly, John E, Curotto de Lafaille, Maria A, Wakeland, Edward K, Fairhurst, Anna-Marie

“…Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the production of antinuclear autoantibodies. Antinuclear…”
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Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians by Molineros, Julio E, Looger, Loren L, Kim, Kwangwoo, Okada, Yukinori, Terao, Chikashi, Sun, Celi, Zhou, Xu-Jie, Raj, Prithvi, Kochi, Yuta, Suzuki, Akari, Akizuki, Shuji, Nakabo, Shuichiro, Bang, So-Young, Lee, Hye-Soon, Kang, Young Mo, Suh, Chang-Hee, Chung, Won Tae, Park, Yong-Beom, Choe, Jung-Yoon, Shim, Seung-Cheol, Lee, Shin-Seok, Zuo, Xiaoxia, Yamamoto, Kazuhiko, Li, Quan-Zhen, Shen, Nan, Porter, Lauren L, Harley, John B, Chua, Kek Heng, Zhang, Hong, Wakeland, Edward K, Tsao, Betty P, Bae, Sang-Cheol, Nath, Swapan K

“…Human leukocyte antigen (HLA) is a key genetic factor conferring risk of systemic lupus erythematosus (SLE), but precise independent localization of HLA…”
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Yaa autoimmune phenotypes are conferred by overexpression of TLR7 by Fairhurst, Anna-Marie, Hwang, Sun-hee, Wang, Andrew, Tian, Xiang-Hong, Boudreaux, Christopher, Zhou, Xin J, Casco, Jose, Li, Quan-Zhen, Connolly, John E, Wakeland, Edward K

“…The Y-linked autoimmune accelerating (Yaa) locus drives the transition to fatal lupus nephritis when combined with B6.Sle1 in our C57BL/6J (B6)-congenic model…”
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RNA sensing by conventional dendritic cells is central to the development of lupus nephritis by Celhar, Teja, Hopkins, Richard, Thornhill, Susannah I., De Magalhaes, Raquel, Hwang, Sun-Hee, Lee, Hui-Yin, Yasuga, Hiroko, Jones, Leigh A., Casco, Jose, Lee, Bernett, Thamboo, Thomas P., Zhou, Xin J., Poidinger, Michael, Connolly, John E., Wakeland, Edward K., Fairhurst, Anna-Marie

“…Glomerulonephritis is a common and debilitating feature of systemic lupus erythematosus (SLE). The precise immune mechanisms that drive the progression from…”
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Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity by Raj, Prithvi, Rai, Ekta, Song, Ran, Khan, Shaheen, Wakeland, Benjamin E, Viswanathan, Kasthuribai, Arana, Carlos, Liang, Chaoying, Zhang, Bo, Dozmorov, Igor, Carr-Johnson, Ferdicia, Mitrovic, Mitja, Wiley, Graham B, Kelly, Jennifer A, Lauwerys, Bernard R, Olsen, Nancy J, Cotsapas, Chris, Garcia, Christine K, Wise, Carol A, Harley, John B, Nath, Swapan K, James, Judith A, Jacob, Chaim O, Tsao, Betty P, Pasare, Chandrashekhar, Karp, David R, Li, Quan Zhen, Gaffney, Patrick M, Wakeland, Edward K

“…Targeted sequencing of sixteen SLE risk loci among 1349 Caucasian cases and controls produced a comprehensive dataset of the variations causing susceptibility…”
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Risk factors for ANA positivity in healthy persons by Li, Quan-Zhen, Karp, David R, Quan, Jiexia, Branch, Valerie K, Zhou, Jinchun, Lian, Yun, Chong, Benjamin F, Wakeland, Edward K, Olsen, Nancy J

“…The finding of antinuclear antibody (ANA) positivity in a healthy individual is usually of unknown significance and in most cases is benign. However, a subset…”
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Distinct autoantibody profiles across checkpoint inhibitor types and toxicities by Mu-Mosley, Hong, von Itzstein, Mitchell S, Fattah, Farjana, Liu, Jialiang, Zhu, Chengsong, Xie, Yang, Wakeland, Edward K, Park, Jason Y, Kahl, Brad S, Diefenbach, Catherine S, Gerber, David E

“…Immune checkpoint inhibitors (ICI) are increasingly used in combination. To understand the effects of different ICI categories, we characterized changes in…”
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Genomic Heterogeneity of Methicillin Resistant Staphylococcus aureus Associated with Variation in Severity of Illness among Children with Acute Hematogenous Osteomyelitis by Gaviria-Agudelo, Claudia, Aroh, Chukwuemika, Tareen, Naureen, Wakeland, Edward K, Kim, MinSoo, Copley, Lawson A

“…The association between severity of illness of children with osteomyelitis caused by Methicillin-resistant Staphylococcus aureus (MRSA) and genomic variation…”
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CXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of Lupus by Wang, Andrew, Fairhurst, Anna-Marie, Tus, Katalin, Subramanian, Srividya, Liu, Yang, Lin, Fangming, Igarashi, Peter, Zhou, Xin J, Batteux, Frederic, Wong, Donald, Wakeland, Edward K, Mohan, Chandra

“…Among various surface molecules screened, CXCR4 was significantly up-regulated on monocytes, neutrophils, B cell subsets, and plasma cells in multiple murine…”
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The role of SLAM/CD2 polymorphisms in systemic autoimmunity by Wang, Andrew, Batteux, Frederic, Wakeland, Edward K

“…The SLAM/CD2 gene family encodes receptors that play important roles in regulating multiple cellular interactions in the adaptive and innate immune systems…”
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