Search Results - "Wake, Matthew"

STAT3 the oncogene – still eluding therapy? by Wake, Matthew S., Watson, Christine J.

“…The STAT family of transcription factors (signal transducers and activators of transcription) transduce signals from cytokine receptors to the nucleus, where…”
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'In-Format' screening of a novel bispecific antibody format reveals significant potency improvements relative to unformatted molecules by Scott, Martin J, Lee, Jennifer A, Wake, Matthew S, Batt, Kelly V, Wattam, Trevor A, Hiles, Ian D, Batuwangala, Thil D, Ashman, Claire I, Steward, Michael

“…Bispecific antibodies (BsAbs) are emerging as an important class of biopharmaceutical. The majority of BsAbs are created from conventional antibodies or…”
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Use of dual-task methodology for skill assessment and development: Examples from rugby league by Gabbett, Tim, Wake, Matthew, Abernethy, Bruce

“…We assessed the attentional demands of drawing and passing in rugby league players and investigated the effects of single-task and dual-task training on the…”
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Analysis of di-methyl ether production routes: Process performance evaluations at various syngas compositions by Luu, Minh Tri, Milani, Dia, Wake, Matthew, Abbas, Ali

“…This paper investigates direct di-methyl ether (DME) production based on dry methane reforming (DMR-to-DME) and on bireforming (BiR-to-DME). Technically,…”
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STAT 3 the oncogene – still eluding therapy? by Wake, Matthew S., Watson, Christine J.

“…The STAT family of transcription factors (signal transducers and activators of transcription) transduce signals from cytokine receptors to the nucleus, where…”
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A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease by Petzer, Verena, Tymoszuk, Piotr, Asshoff, Malte, Carvalho, Joana, Papworth, Jonathan, Deantonio, Cecilia, Bayliss, Luke, Wake, Matthew Stephen, Seifert, Markus, Brigo, Natascha, Valente de Souza, Lara, Hilbe, Richard, Grubwieser, Philipp, Demetz, Egon, Dichtl, Stefanie, Volani, Chiara, Berger, Sylvia, Böhm, Felix, Hoffmann, Alexander, Pfeifhofer-Obermair, Christa, von Raffay, Laura, Sopper, Sieghart, Arndt, Stephanie, Bosserhoff, Anja, Kautz, Léon, Perrier, Prunelle, Nairz, Manfred, Wolf, Dominik, Weiss, Guenter, Germaschewski, Volker, Theurl, Igor

“…Recombinant erythropoietin (EPO) and iron substitution are a standard of care for treatment of anemias associated with chronic inflammation, including anemia…”
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KY1044 to target the ICOS pathways inducing intratumoral Treg depletion and agonism of effector T cells: Preliminary pharmacodynamic markers from a phase 1/2 multicenter trial by Lin, Chia-Chi, Naing, Aung, Patel, Manish R., Burris III, Howard A., Curigliano, Giuseppe, Thistlethwaite, Fiona, Minchom, Anna Rachel, Ascierto, Paolo Antonio, De Braud, Filippo G., Eder, Joseph Paul, Wake, Matthew, Palu, Cintia Cristina, Newton, Anthea Louise, Deantonio, Cecilia, Hanekom, Wouter, Sainson, Richard C.A, Quaratino, Sonia

“…Abstract only 2626 Background: Inducible T-cell co-stimulator (ICOS) is an important co-stimulatory receptor on effector T cells (Teffs) that also promotes…”
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Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia by Wake, Matthew, Papworth, Jonathan, Bayliss, Luke, Grimshaw, Benjamin, Rynkiewicz, Natalie, Paterson, Jemima, Poindron, Alicia, Spearing, Erin, Carter, Emily, Hudson, Robyne, Petzer, Verena, Largounez, Amelie, Belot, Audrey, Palin, Anais, Theurl, Igor, Germaschewski, Volker, Meynard, Delphine

“…Beta thalassemia is an inherited hemoglobinopathy caused by a genetic defect in beta-globin gene and characterised by ineffective erythropoiesis, iron…”
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A Fully Human Anti-BMP6 Antibody Reduces the Need for Erythropoietin Stimulating Agent in Two Rodent Anemia of Chronic Disease Models by Petzer, Verena, Tymoszuk, Piotr, Wake, Matthew, Bayliss, Luke, Papworth, Jonathan, Carvalho, Joana, Deantonio, Cecilia, Asshoff, Malte Ferdinand, Seifert, Markus, Berger, Sylvia, Wolf, Dominik, Weiss, Günter, Germaschewski, Volker, Theurl, Igor

“…Anemia of chronic disease (ACD) is the most common cause of anemia in hospitalized patients. The underlying pathophysiological mechanisms are manifold,…”
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A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice by Wake, Matthew, Palin, Anaïs, Belot, Audrey, Berger, Mathieu, Lorgouilloux, Megane, Bichon, Margot, Papworth, Jonathan, Bayliss, Luke, Grimshaw, Benjamin, Rynkiewicz, Natalie, Paterson, Jemima, Poindron, Alicia, Spearing, Erin, Carter, Emily, Hudson, Robyne, Campbell, Millie, Petzer, Verena, Besson-Fournier, Céline, Latour, Chloé, Largounez, Amélie, Gourbeyre, Ophélie, Fay, Alexis, Coppin, Hélène, Roth, Marie-Paule, Theurl, Igor, Germaschewski, Volker, Meynard, Delphine

“…•RLYB331 is a human antibody that increases hepcidin, reduces iron overload, and ameliorates ineffective erythropoiesis in β-thalassemia•Combination with…”
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'In-Format' screening of a novel bispecific antibody format reveals significant potency improvements relative to unformatted molecules by Scott, Martin J., Lee, Jennifer A., Wake, Matthew S., Batt, Kelly V., Wattam, Trevor A., Hiles, Ian D., Batuwangala, Thil D., Ashman, Claire I., Steward, Michael

“…Bispecific antibodies (BsAbs) are emerging as an important class of biopharmaceutical. The majority of BsAbs are created from conventional antibodies or…”
Get full text