Search Results - "Wake, D. J."

Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women by Goedecke, J. H., Wake, D. J., Levitt, N. S., Lambert, E. V., Collins, M. R., Morton, N. M., Andrew, R., Seckl, J. R., Walker, B. R.

“…Summary Objective  Glucocorticoid hyperactivity in adipose tissue, due to up‐regulation of local glucocorticoid reactivation by 11β‐hydroxysteroid…”
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Assessment of the effect of the COVID‐19 lockdown on glycaemic control in people with type 1 diabetes using flash glucose monitoring by Dover, A. R., Ritchie, S. A., McKnight, J. A., Strachan, M. W. J., Zammitt, N. N., Wake, D.J., Forbes, S., Stimson, R. H., Gibb, F. W.

“…Aim To describe the effect of the stringent lockdown measures, introduced in the UK on 23 March 2020 to curtail the transmission of COVID‐19, on glycaemic…”
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cGMP signaling inhibits platelet shape change through regulation of the RhoA‐Rho Kinase‐MLC phosphatase signaling pathway by Aburima, A., Walladbegi, K., Wake, J. D., Naseem, K. M.

“…Essentials Platelet shape change requires cytoskeletal rearrangement via myosin‐mediated actin contraction. We investigated whether nitric oxide (NO) affected…”
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In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue by SUTINEN, J, KANNISTO, K, KORSHENINNIKOVA, E, NYMAN, T, EHRENBORG, E, ANDREW, R, WAKE, D. J, HAMSTEN, A, WALKER, B. R, YKI-JÄRVINEN, H

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Altered metabolic parameters in association with antipsychotic medication use in diabetes: A population based case-control study by Wake, D.J, Broughton, P, Perera, S.M, MacIntyre, D.J, Leese, G.P

“…Highlights • This study confirms higher diabetes rates in the schizophrenia population up to age 70 but not beyond, suggesting a survivor effect. • This study…”
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Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl‐2 by XU, S. Z., ZHONG, W., WATSON, N. M., DICKERSON, E., WAKE, J. D., LINDOW, S. W., NEWTON, C. J., ATKIN, S. L.

“…Background: 3‐Hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors (statins) have been widely used in clinical practise and their efficacy in reducing…”
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Blood transfusion in developing countries: problems, priorities and practicalities by Wake, D J, Cutting, W A

“…The acute medical services could not exist without blood transfusions--life-savers in many situations. But transfusions can also be a quick and easy route for…”
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In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue by Sutinen, J, Kannisto, K, Korsheninnikova, E, Nyman, T, Ehrenborg, E, Andrew, R, Wake, D J, Hamsten, A, Walker, B R, Yki-Järvinen, H

“…Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic…”
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11 beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome by Wake, Deborah J, Walker, Brian R

“…11 beta-Hydroxysteroid dehydrogenase type 1 (11HSD1) catalyses the in vivo conversion of inactive to active glucocorticoids. It is a widespread, highly…”
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Local and Systemic Impact of Transcriptional Up-Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue in Human Obesity by Wake, Deborah J., Rask, Eva, Livingstone, Dawn E. W., Söderberg, Stefan, Olsson, Tommy, Walker, Brian R.

“…In idiopathic obesity circulating cortisol levels are not elevated, but high intraadipose cortisol concentrations have been implicated. 11β-Hydroxysteroid…”
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Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Activity and Messenger Ribonucleic Acid Levels Are Associated with Adiposity and Insulinemia in Pima Indians and Caucasians by Lindsay, Robert S., Wake, Deborah J., Nair, Saraswathy, Bunt, Joy, Livingstone, Dawn E. W., Permana, Paska A., Tataranni, P. Antonio, Walker, Brian R.

“…Metabolic effects of cortisol may be critically modulated by glucocorticoid metabolism in tissues. Specifically, active cortisol is regenerated from inactive…”
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Body Fat Distribution and Cortisol Metabolism in Healthy Men: Enhanced 5β-Reductase and Lower Cortisol/Cortisone Metabolite Ratios in Men with Fatty Liver by Westerbacka, Jukka, Yki-Järvinen, Hannele, Vehkavaara, Satu, Häkkinen, Anna-Maija, Andrew, Ruth, Wake, Deborah J., Seckl, Jonathan R., Walker, Brian R.

“…In Cushing’s syndrome, cortisol causes fat accumulation in specific sites most likely to be associated with insulin resistance, notably in omental adipose and…”
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In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing?s syndrome is associated with increased regeneration of cortisol by 11?-hydroxysteroid dehydrogenase type 1 in adipose tissue by Sutinen, J., Kannisto, K., Korsheninnikova, E., Nyman, T., Ehrenborg, E., Andrew, R., Wake, D. J., Hamsten, A., Walker, B. R., Yki-J rvinen, H.

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In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11-hydroxysteroid dehydrogenase type 1 in adipose tissue by Sutinen, J, Kannisto, K, Korsheninnikova, E, Nyman, T, Ehrenborg, E, Andrew, R, Wake, D J, Hamsten, A, Walker, B R, Yki-Järvinen, H

“…Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic…”
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Noise of Diesel Engines Under Transient Conditions by Head, H. E., Wake, J. D.

“…Diesel engines accelerating under full load conditions radiate more noise from their surfaces than when they are run at steady speed with the same fuelling…”
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