Search Results - "Wakayama, Tomohiko"

Angulin-1 seals tricellular contacts independently of tricellulin and claudins by Sugawara, Taichi, Furuse, Kyoko, Otani, Tetsuhisa, Wakayama, Tomohiko, Furuse, Mikio

“…Tricellular tight junctions (tTJs) are specialized tight junctions (TJs) that seal the intercellular space at tricellular contacts (TCs), where the vertices of…”
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Development of a non-invasive method for testicular toxicity evaluation using a novel compact magnetic resonance imaging system by Yokota, Satoshi, Miyaso, Hidenobu, Hirai, Toshinori, Suga, Kousuke, Wakayama, Tomohiko, Taquahashi, Yuhji, Kitajima, Satoshi

“…In non-clinical animal studies for drug discovery, histopathological evaluation is the most powerful tool to assess testicular toxicity. However, histological…”
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The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis by Sato, Michio, Kadomatsu, Tsuyoshi, Miyata, Keishi, Warren, Junco S., Tian, Zhe, Zhu, Shunshun, Horiguchi, Haruki, Makaju, Aman, Bakhtina, Anna, Morinaga, Jun, Sugizaki, Taichi, Hirashima, Kaname, Yoshinobu, Kumiko, Imasaka, Mai, Araki, Masatake, Komohara, Yoshihiro, Wakayama, Tomohiko, Nakagawa, Shinichi, Franklin, Sarah, Node, Koichi, Araki, Kimi, Oike, Yuichi

“…In the past decade, many long noncoding RNAs (lncRNAs) have been identified and their in vitro functions defined, although in some cases their functions in…”
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Quantitative Analysis of the Cellular Composition in Seminiferous Tubules in Normal and Genetically Modified Infertile Mice by Nakata, Hiroki, Wakayama, Tomohiko, Takai, Yoshimi, Iseki, Shoichi

“…The aim of this study was to establish a quantitative standard for the cellular composition in seminiferous tubules at each stage of spermatogenesis in the…”
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Quantitative evaluation of spermatogenesis by fluorescent histochemistry by Wakayama, Tomohiko, Yokota, Satoshi, Noguchi, Kazuhiro, Sugawara, Taichi, Sonoda, Kayoko, Wanta, Arunothai

“…Identifying the types of spermatogenic cells that compose seminiferous tubules, as well as qualitative confirmation of the presence or absence of disorders,…”
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Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1 by Kato, Yukio, Kubo, Yoshiyuki, Iwata, Daisuke, Kato, Sayaka, Sudo, Tomohisa, Sugiura, Tomoko, Kagaya, Takashi, Wakayama, Tomohiko, Hirayama, Akiyoshi, Sugimoto, Masahiro, Sugihara, Kazushi, Kaneko, Shuichi, Soga, Tomoyoshi, Asano, Masahide, Tomita, Masaru, Matsui, Toshiyuki, Wada, Morimasa, Tsuji, Akira

“…Purpose Solute carrier OCTN1 (SLC22A4) is an orphan transporter, the physiologically important substrate of which is still unidentified. The aim of the present…”
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Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition by Hasan Alshammari, Aya, Masuo, Yusuke, Fujita, Ken-ichi, Shimada, Kazuhiro, Iida, Noriho, Wakayama, Tomohiko, Kato, Yukio

“…[Display omitted] Tyrosine kinase inhibitors (TKIs) are molecular-targeted anticancer drugs. Their benefits are limited by dermal toxicities, including…”
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Correction to: Quantitative evaluation of spermatogenesis by fluorescent histochemistry by Wakayama, Tomohiko, Yokota, Satoshi, Noguchi, Kazuhiro, Sugawara, Taichi, Sonoda, Kayoko, Wanta, Arunothai

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Impact of chronic vitamin A excess on sperm morphogenesis in mice by Yokota, Satoshi, Sekine, Nao, Wakayama, Tomohiko, Oshio, Shigeru

“…Background The increasing availability of fortified foods and supplements has caused an overconsumption of vitamin A (VA), above the recommended level. To…”
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Identification of sperm equatorial segment protein 1 in the acrosome as the primary binding target of peanut agglutinin (PNA) in the mouse testis by Nakata, Hiroki, Wakayama, Tomohiko, Asano, Tomoya, Nishiuchi, Takumi, Iseki, Shoichi

“…Peanut agglutinin (PNA), a plant lectin protein that recognizes the galactose β (1 −> 3) N -acetylgalactosamine carbohydrate sequence, has been widely used as…”
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Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH by Maeda, Hitoshi, Ishima, Yu, Saruwatari, Junji, Mizuta, Yuki, Minayoshi, Yuki, Ichimizu, Shota, Yanagisawa, Hiroki, Nagasaki, Taisei, Yasuda, Kengo, Oshiro, Shun, Taura, Manabu, McConnell, Matthew J., Oniki, Kentaro, Sonoda, Kayoko, Wakayama, Tomohiko, Kinoshita, Manabu, Shuto, Tsuyoshi, Kai, Hirofumi, Tanaka, Motohiko, Sasaki, Yutaka, Iwakiri, Yasuko, Otagiri, Masaki, Watanabe, Hiroshi, Maruyama, Toru

“…Kupffer cells are a key source of reactive oxygen species (ROS) and are implicated in the development of steatohepatitis and fibrosis in nonalcoholic…”
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Three‐dimensional structure of seminiferous tubules in the adult mouse by Nakata, Hiroki, Wakayama, Tomohiko, Sonomura, Takahiro, Honma, Satoru, Hatta, Toshihisa, Iseki, Shoichi

“…Seminiferous tubules develop from sex cords, which are embryonic structures with simple C‐shaped arches. Histologically, the epithelium of adult mouse…”
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Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity by Taguchi, Kazuaki, Nagao, Saori, Maeda, Hitoshi, Yanagisawa, Hiroki, Sakai, Hiromi, Yamasaki, Keishi, Wakayama, Tomohiko, Watanabe, Hiroshi, Otagiri, Masaki, Maruyama, Toru

“…Macrophages play a central role in various inflammatory disorders and are broadly divided into two subpopulations, M1 and M2 macrophage. In the healing process…”
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Food‐derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice by Nakamichi, Noritaka, Nakayama, Keigo, Ishimoto, Takahiro, Masuo, Yusuke, Wakayama, Tomohiko, Sekiguchi, Hirotaka, Sutoh, Keita, Usumi, Koji, Iseki, Shoichi, Kato, Yukio

“…Background Clinically used antidepressants suffer from various side effects. Therefore, we searched for a safe antidepressant with minimal side effects among…”
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Expression of cell adhesion molecule 1 in gastric neck and base glandular cells: Possible involvement in peritoneal dissemination of signet ring cells by Kimura, Ryuichiro, Yoneshige, Azusa, Hagiyama, Man, Otani, Tomoyuki, Inoue, Takao, Shiraishi, Naoki, Yanagihara, Kazuyoshi, Wakayama, Tomohiko, Ito, Akihiko

“…To determine cellular distribution of cell adhesion molecule 1 (CADM1), an immunoglobulin superfamily member, in the human oxyntic gastric mucosa, and to…”
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Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis by Nakanishi, Takeo, Hasegawa, Yoshitaka, Mimura, Reo, Wakayama, Tomohiko, Uetoko, Yuka, Komori, Hisakazu, Akanuma, Shin-Ichi, Hosoya, Ken-Ichi, Tamai, Ikumi

“…Prostaglandin (PG) E2 exhibits an anti-fibrotic effect in the lung in response to inflammatory reactions and is a high-affinity substrate of PG transporter…”
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In vivo evidence of organic cation transporter-mediated tracheal accumulation of the anticholinergic agent ipratropium in mice by Nakanishi, Takeo, Hasegawa, Yoshitaka, Haruta, Tsunemitsu, Wakayama, Tomohiko, Tamai, Ikumi

“…Ipratropium bromide (IPR) is an anticholinergic used to treat chronic obstructive pulmonary disease (COPD), and is a substrate of organic cation transporters…”
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Localization of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis by Tang, Yaliang, Masuo, Yusuke, Sakai, Yoshio, Wakayama, Tomohiko, Sugiura, Tomoko, Harada, Ryuichi, Futatsugi, Azusa, Komura, Takuya, Nakamichi, Noritaka, Sekiguchi, Hirotaka, Sutoh, Keita, Usumi, Koji, Iseki, Shoichi, Kaneko, Shuichi, Kato, Yukio

“…Xenobiotic transporters play key roles in disposition of certain therapeutic agents, although limited information is available on their roles other than…”
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Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation by Nakamichi, Noritaka, Taguchi, Takayuki, Hosotani, Hiroshi, Wakayama, Tomohiko, Shimizu, Takuya, Sugiura, Tomoko, Iseki, Shoichi, Kato, Yukio

“…[Display omitted] ► OCTN1/SLC22A4 is functionally expressed in the brain. ► OCTN1 is localized in both neuronal cell bodies and dendrites. ► Inhibition of…”
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Phosphodiesterase III inhibitor attenuates rat sinusoidal obstruction syndrome through inhibition of platelet aggregation in Disse's space by Miyata, Takashi, Tajima, Hidehiro, Hirata, Miki, Nakanuma, Shin‐ichi, Makino, Isamu, Hayashi, Hironori, Oyama, Katsunobu, Miyashita, Tomoharu, Takamura, Hiroyuki, Ninomiya, Itasu, Fushida, Sachio, Iseki, Shoichi, Harada, Shin‐ichi, Wakayama, Tomohiko, Ohta, Tetsuo

“…Background and Aim Sinusoidal obstruction syndrome (SOS) is a serious drug‐induced liver injury. However, the pathophysiology of the disease remains unclear…”
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