Search Results - "Wakasa, Yuhya"

Signal transduction by IRE1‐mediated splicing of bZIP50 and other stress sensors in the endoplasmic reticulum stress response of rice by Hayashi, Shimpei, Wakasa, Yuhya, Takahashi, Hideyuki, Kawakatsu, Taiji, Takaiwa, Fumio

“…The endoplasmic reticulum (ER) stress sensor IRE1 transduces signals by inducing the unconventional splicing of mRNAs encoding key transcription factors: HAC1…”
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An overview on the strategies to exploit rice endosperm as production platform for biopharmaceuticals by Takaiwa, Fumio, Wakasa, Yuhya, Hayashi, Shimpei, Kawakatsu, Taiji

“…•PBs in seeds provide good production platform for high-value products.•Secretory proteins are targeted to PBs by attaching C terminal KDEL signal in…”
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Rice seed for delivery of vaccines to gut mucosal immune tissues by Takaiwa, Fumio, Wakasa, Yuhya, Takagi, Hidenori, Hiroi, Takachika

“…Gut-associated lymphoid tissue (GALT) is the biggest lymphoid organ in the body. It plays a role in robust immune responses against invading pathogens while…”
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Safety and efficacy of rice seed-based oral allergy vaccine for Japanese cedar pollinosis in Japanese monkeys by Saito, Saburo, Takagi, Hidenori, Wakasa, Yuhya, Ozawa, Kenjirou, Takaiwa, Fumio

“…•Transgenic rice containing modified cedar pollen allergens was used as oral tolerogen.•Transgenic rice was orally administered to Japanese…”
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The use of rice seeds to produce human pharmaceuticals for oral therapy by Wakasa, Yuhya, Takaiwa, Fumio

“…Rice (Oryza sativa L.) is the major staple food consumed by half of the world's population. Rice seeds have gained recent attention as bioreactors for the…”
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Development of Rice-Seed-Based Oral Allergy Vaccines Containing Hypoallergenic Japanese Cedar Pollen Allergen Derivatives for Immunotherapy by Takaiwa, Fumio, Yang, Lijun, Takagi, Hidenori, Maruyama, Nobuyuki, Wakasa, Yuhya, Ozawa, Kenjiro, Hiroi, Takachika

“…Allergen-specific immunotherapy is the only available curative treatment for IgE-mediated allergen diseases. A safe hypoallergenic allergen derivative with…”
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Characterization of IRE1 ribonuclease-mediated mRNA decay in plants using transient expression analyses in rice protoplasts by Hayashi, Shimpei, Wakasa, Yuhya, Ozawa, Kenjirou, Takaiwa, Fumio

“…In some eukaryotes, endoplasmic reticulum (ER) stress induces regulated inositol-requiring enzyme 1 (IRE1)-dependent decay (RIDD) of mRNAs. Recently, the…”
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A Rice Transmembrane bZIP Transcription Factor, OsbZIP39, Regulates the Endoplasmic Reticulum Stress Response by Takahashi, Hideyuki, Kawakatsu, Taiji, Wakasa, Yuhya, Hayashi, Shimpei, Takaiwa, Fumio

“…The endoplasmic reticulum (ER) responds to the accumulation of unfolded proteins in its lumen (ER stress) by activating intracellular signal transduction…”
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Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice by Fukuda, Ken, Ishida, Waka, Harada, Yosuke, Wakasa, Yuhya, Takagi, Hidenori, Takaiwa, Fumio, Fukushima, Atsuki

“…We have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development…”
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Expression of ER quality control-related genes in response to changes in BiP1 levels in developing rice endosperm by Wakasa, Yuhya, Yasuda, Hiroshi, Oono, Youko, Kawakatsu, Taiji, Hirose, Sakiko, Takahashi, Hideyuki, Hayashi, Shimpei, Yang, Lijun, Takaiwa, Fumio

“…Binding protein (BiP) is the key chaperone involved in folding of secretory proteins such as seed storage proteins in the ER lumen. To obtain functional…”
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Transgene‐independent heredity of RdDM‐mediated transcriptional gene silencing of endogenous genes in rice by Wakasa, Yuhya, Kawakatsu, Taiji, Harada, Takeo, Takaiwa, Fumio

“…Summary To induce transcriptional gene silencing (TGS) of endogenous genes of rice (Oryza sativa L.), we expressed double‐strand RNA of each promoter region…”
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Multiple roles of the ER stress sensor IRE1 demonstrated by gene targeting in rice by Wakasa, Yuhya, Hayashi, Shimpei, Ozawa, Kenjirou, Takaiwa, Fumio

“…The endoplasmic reticulum (ER) stress sensor, IRE1, contains a kinase domain and a ribonuclease domain. Ribonuclease mediates the unconventional splicing of…”
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Oral Immunotherapy for Allergic Conjunctivitis Using Transgenic Rice Expressing Hypoallergenic Antigens by Fukuda, Ken, Ishida, Waka, Wakasa, Yuhya, Takagi, Hidenori, Takaiwa, Fumio, Fukushima, Atsuki

“…Pollinosis, or allergic conjunctivitis and rhinitis induced by pollen, is one of the most common diseases worldwide. In Japan, Japanese cedar (Cryptomeria…”
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Null Mutation of the MdACS3 Gene, Coding for a Ripening-Specific 1-Aminocyclopropane-1-Carboxylate Synthase, Leads to Long Shelf Life in Apple Fruit by Wang, Aide, Yamakake, Junko, Kudo, Hisayuki, Wakasa, Yuhya, Hatsuyama, Yoshimichi, Igarashi, Megumi, Kasai, Atsushi, Li, Tianzhong, Harada, Takeo

“…Expression of MdACS1, coding for 1-aminocyclopropane-1-carboxylate synthase (ACS), parallels the level of ethylene production in ripening apple (Malus…”
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Development of an efficient agrobacterium-mediated gene targeting system for rice and analysis of rice knockouts lacking granule-bound starch synthase (Waxy) and β1,2-xylosyltransferase by Ozawa, Kenjirou, Wakasa, Yuhya, Ogo, Yuko, Matsuo, Kouki, Kawahigashi, Hiroyuki, Takaiwa, Fumio

“…We have developed a high-frequency method for Agrobacterium-mediated gene targeting by combining an efficient transformation system using rice…”
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Prevention of allergic conjunctivitis in mice by a rice-based edible vaccine containing modified Japanese cedar pollen allergens by Fukuda, Ken, Ishida, Waka, Harada, Yosuke, Wakasa, Yuhya, Takagi, Hidenori, Takaiwa, Fumio, Fukushima, Atsuki

“…To determine whether oral immunotherapy with transgenic rice seeds expressing hypoallergenic modified antigens suppresses cedar pollen-induced allergic…”
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Endosperm tissue is good production platform for artificial recombinant proteins in transgenic rice by Takaiwa, Fumio, Takagi, Hidenori, Hirose, Sakiko, Wakasa, Yuhya

“…Transgenic rice plants expressing 7Crp peptide were generated by Agrobacterium-mediated transformation. The 7Crp peptide is the hybrid peptide of seven major…”
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RNA sequencing-mediated transcriptome analysis of rice plants in endoplasmic reticulum stress conditions by Wakasa, Yuhya, Oono, Youko, Yazawa, Takayuki, Hayashi, Shimpei, Ozawa, Kenjirou, Handa, Hirokazu, Matsumoto, Takashi, Takaiwa, Fumio

“…The endoplasmic reticulum (ER) stress response is widely known to function in eukaryotes to maintain the homeostasis of the ER when unfolded or misfolded…”
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ER stress response induced by the production of human IL-7 in rice endosperm cells by Kudo, Kyoko, Ohta, Masaru, Yang, Lijun, Wakasa, Yuhya, Takahashi, Sakiko, Takaiwa, Fumio

“…Rice seed has been used as a production platform for high value recombinant proteins. When mature human interleukin 7 (hIL-7) was expressed as a secretory…”
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Overexpression of BiP has inhibitory effects on the accumulation of seed storage proteins in endosperm cells of rice by Yasuda, H.(National Inst. of Agrobiological Sciences, Tsukuba, Ibaraki (Japan)), Hirose, S, Kawakatsu, T, Wakasa, Y, Takaiwa, F

“…Seed storage proteins are specifically and highly synthesized during seed maturation and are deposited into protein bodies (PBs) via the endoplasmic reticulum…”
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