Search Results - "Wakarchuk, Warren W"

Proteomic Analysis of the Secretome of Cellulomonas fimi ATCC 484 and Cellulomonas flavigena ATCC 482 by Wakarchuk, Warren W, Brochu, Denis, Foote, Simon, Robotham, Anna, Saxena, Hirak, Erak, Tamara, Kelly, John

“…The bacteria in the genus Cellulomonas are known for their ability to degrade plant cell wall biomass. Cellulomonas fimi ATCC 484 and C. flavigena ATCC 482…”
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Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection by Neu, Ursula, Hengel, Holger, Blaum, Bärbel S, Schowalter, Rachel M, Macejak, Dennis, Gilbert, Michel, Wakarchuk, Warren W, Imamura, Akihiro, Ando, Hiromune, Kiso, Makoto, Arnberg, Niklas, Garcea, Robert L, Peters, Thomas, Buck, Christopher B, Stehle, Thilo

“…The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised…”
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Site-specific enzymatic polysialylation of therapeutic proteins using bacterial enzymes by Lindhout, Theresa, Iqbal, Umar, Willis, Lisa M., Reid, Anne N., Li, Jianjun, Liu, Xin, Moreno, Maria, Wakarchuk, Warren W., Wong, Chi-Huey

“…The posttranslational modification of therapeutic proteins with terminal sialic acids is one means of improving their circulating half-life, thereby improving…”
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Fluorescence Activated Cell Sorting as a General Ultra-High-Throughput Screening Method for Directed Evolution of Glycosyltransferases by Yang, Guangyu, Rich, Jamie R, Gilbert, Michel, Wakarchuk, Warren W, Feng, Yan, Withers, Stephen G

“…Glycosyltransferases (GTs) offer very attractive approaches to the synthesis of complex oligosaccharides. However, the limited number of available GTs,…”
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High-throughput screening methodology for the directed evolution of glycosyltransferases by Withers, Stephen G, Aharoni, Amir, Thieme, Karena, Chiu, Cecilia P C, Buchini, Sabrina, Lairson, Luke L, Chen, Hongming, Strynadka, Natalie C J, Wakarchuk, Warren W

“…Engineering of glycosyltransferases (GTs) with desired substrate specificity for the synthesis of new oligosaccharides holds great potential for the…”
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Distinct Endocytic Mechanisms of CD22 (Siglec-2) and Siglec-F Reflect Roles in Cell Signaling and Innate Immunity by Tateno, Hiroaki, Li, Hongyi, Schur, Melissa J., Bovin, Nicolai, Crocker, Paul R., Wakarchuk, Warren W., Paulson, James C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Biochemical characterization of a polysialyltransferase from Mannheimia haemolytica A2 and comparison to other bacterial polysialyltransferases by Lindhout, Theresa, Bainbridge, Cynthia R, Costain, Will J, Gilbert, Michel, Wakarchuk, Warren W

“…Polysialic acids are bioactive carbohydrates found in eukaryotes and some bacterial pathogens. The bacterial polysialyltransferases (PSTs), which catalyze the…”
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7‑Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins by Geissner, Andreas, Baumann, Lars, Morley, Thomas J, Wong, Andrew K. O, Sim, Lyann, Rich, Jamie R, So, Pauline P. L, Dullaghan, Edie M, Lessard, Etienne, Iqbal, Umar, Moreno, Maria, Wakarchuk, Warren W, Withers, Stephen G

“…The maintenance of therapeutic glycoproteins within the circulatory system is associated, in large part, with the integrity of sialic acids as terminal sugars…”
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Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria meningitidis by Lin, Leo Y.-C., Rakic, Bojana, Chiu, Cecilia P.C., Lameignere, Emilie, Wakarchuk, Warren W., Withers, Stephen G., Strynadka, Natalie C.J.

“…The first x-ray crystallographic structure of a CAZY family-52 glycosyltransferase, that of the membrane associated α2,3/α2,6 lipooligosaccharide…”
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Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis by Withers, Stephen G, Lairson, Luke L, Watts, Andrew G, Wakarchuk, Warren W

“…Despite their unparalleled catalytic prowess and environmental compatibility, enzymes have yet to see widespread application in synthetic chemistry. This lack…”
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Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses by Karlyshev, Andrey V., Champion, Olivia L., Churcher, Carol, Brisson, Jean‐Robert, Jarrell, Harold C., Gilbert, Michel, Brochu, Denis, St Michael, Frank, Li, Jianjun, Wakarchuk, Warren W., Goodhead, Ian, Sanders, Mandy, Stevens, Kim, White, Brian, Parkhill, Julian, Wren, Brendan W., Szymanski, Christine M.

“…Summary We recently demonstrated that Campylobacter jejuni produces a capsular polysaccharide (CPS) that is the major antigenic component of the classical…”
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A Single Bifunctional UDP-GlcNAc/Glc 4-Epimerase Supports the Synthesis of Three Cell Surface Glycoconjugates in Campylobacter jejuni by Bernatchez, Stéphane, Szymanski, Christine M., Ishiyama, Noboru, Li, Jianjun, Jarrell, Harold C., Lau, Peter C., Berghuis, Albert M., Young, N. Martin, Wakarchuk, Warren W.

“…The major cell-surface carbohydrates (lipooligosaccharide, capsule, and glycoprotein N-linked heptasaccharide) of Campylobacter jejuni NCTC 11168 contain Gal…”
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Structural and Functional Characterization of PseC, an Aminotransferase Involved in the Biosynthesis of Pseudaminic Acid, an Essential Flagellar Modification in Helicobacter pylori by Schoenhofen, Ian C., Lunin, Vladimir V., Julien, Jean-Philippe, Li, Yunge, Ajamian, Eunice, Matte, Allan, Cygler, Miroslaw, Brisson, Jean-Robert, Aubry, Annie, Logan, Susan M., Bhatia, Smita, Wakarchuk, Warren W., Young, N. Martin

“…Helicobacter pylori flagellin is heavily glycosylated with the novel sialic acid-like nonulosonate, pseudaminic acid (Pse). The glycosylation process is…”
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Identification and Characterization of NeuB3 from Campylobacter jejuni as a Pseudaminic Acid Synthase by Chou, Wayne K., Dick, Scott, Wakarchuk, Warren W., Tanner, Martin E.

“…Campylobacter jejuni and Campylobacter coli are the main causes of bacterial diarrhea worldwide, and Helicobacter pylori is known to cause duodenal ulcers. In…”
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Structural and Kinetic Characterizations of the Polysialic Acid O-Acetyltransferase OatWY from Neisseria meningitidis by Lee, Ho Jun, Rakić, Bojana, Gilbert, Michel, Wakarchuk, Warren W., Withers, Stephen G., Strynadka, Natalie C.J.

“…The neuroinvasive pathogen Neisseria meningitidis has 13 capsular serogroups, but the majority of disease is caused by only 5 of these. Groups B, C, Y, and…”
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Energetic adaptations: Metabolic control of endocytic membrane traffic by Rahmani, Sadia, Defferrari, Marina S., Wakarchuk, Warren W., Antonescu, Costin N.

“…Endocytic membrane traffic controls the access of myriad cell surface proteins to the extracellular milieu, and thus gates nutrient uptake, ion homeostasis,…”
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NMR Spectroscopic Characterization of the Sialyltransferase CstII from Campylobacter jejuni: Histidine 188 Is the General Base by Chan, Patrick H. W, Lairson, Luke L, Lee, Ho Jun, Wakarchuk, Warren W, Strynadka, Natalie C. J, Withers, Stephen G, McIntosh, Lawrence P

“…Cell surface glycans are often terminated by sialic acid, which is incorporated onto sugar acceptors by sialyltransferases. The crystal structure of the GT…”
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Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo by Sim, Lyann, Thompson, Nicole, Geissner, Andreas, Withers, Stephen G, Wakarchuk, Warren W

“…Abstract The prospect of producing human-like glycoproteins in bacteria is becoming attractive as an alternative to already-established but costly mammalian…”
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Structural and Mechanistic Analysis of Sialic Acid Synthase NeuB from Neisseria meningitidis in Complex with Mn2+, Phosphoenolpyruvate, and N-Acetylmannosaminitol by Gunawan, Jason, Simard, Dave, Gilbert, Michel, Lovering, Andrew L., Wakarchuk, Warren W., Tanner, Martin E., Strynadka, Natalie C.J.

“…In Neisseria meningitidis and related bacterial pathogens, sialic acids play critical roles in mammalian cell immunity evasion and are synthesized by a…”
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O-GlcNAc transferase modulates the cellular endocytosis machinery by controlling the formation of clathrin-coated pits by Rahmani, Sadia, Ahmed, Hafsa, Ibazebo, Osemudiamen, Fussner-Dupas, Eden, Wakarchuk, Warren W., Antonescu, Costin N.

“…Clathrin-mediated endocytosis (CME) controls the internalization and function of a wide range of cell surface proteins. CME occurs by the assembly of clathrin…”
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