Search Results - "Wajant, Harald"

The TWEAK‐Fn14 system as a potential drug target by Wajant, Harald

“…Fibroblast growth factor‐inducible 14 (Fn14) is a member of the tumour necrosis factor (TNF) receptor family that is induced in a variety of cell types in…”
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TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages by Wajant, Harald, Siegmund, Daniela

“…Macrophages stand in the first line of defense against a variety of pathogens but are also involved in the maintenance of tissue homeostasis. To fulfill their…”
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Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target by Medler, Juliane, Wajant, Harald

“…Tumor necrosis factor (TNF) receptor 2 (TNFR2) is one of two receptors of the cytokines, TNF and lymphotoxin-α. TNFR1 is a strong inducer of proinflammatory…”
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The Fas Signaling Pathway: More Than a Paradigm by Wajant, Harald

“…Apoptosis and related forms of cell death have central importance in development, homeostasis, tumor surveillance, and the function of the immune system…”
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Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily by Kucka, Kirstin, Wajant, Harald

“…With the exception of a few signaling incompetent decoy receptors, the receptors of the tumor necrosis factor receptor superfamily (TNFRSF) are signaling…”
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Cell death‐independent activities of the death receptors CD95, TRAILR1, and TRAILR2 by Siegmund, Daniela, Lang, Isabell, Wajant, Harald

“…Since their identification more than 20 years ago, the death receptors CD95, TRAILR1, and TRAILR2 have been intensively studied with respect to their cell…”
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Targeting Regulatory T Cells by Addressing Tumor Necrosis Factor and Its Receptors in Allogeneic Hematopoietic Cell Transplantation and Cancer by Wajant, Harald, Beilhack, Andreas

“…An intricate network of molecular and cellular actors orchestrates the delicate balance between effector immune responses and immune tolerance. The pleiotropic…”
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Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling by Füllsack, Simone, Rosenthal, Alevtina, Wajant, Harald, Siegmund, Daniela

“…We evaluated redundant and receptor-specific activities of TRADD, RIPK1, and FADD in RIPK3-expressing HeLa cells lacking expression of these proteins or any…”
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FcγRs and Their Relevance for the Activity of Anti-CD40 Antibodies by Lang, Isabell, Zaitseva, Olena, Wajant, Harald

“…Inhibitory targeting of the CD40L-CD40 system is a promising therapeutic option in the field of organ transplantation and is also attractive in the treatment…”
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Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation by Cuchet-Lourenço, Delphine, Eletto, Davide, Wu, Changxin, Plagnol, Vincent, Papapietro, Olivier, Curtis, James, Ceron-Gutierrez, Lourdes, Bacon, Chris M, Hackett, Scott, Alsaleem, Badr, Maes, Mailis, Gaspar, Miguel, Alisaac, Ali, Goss, Emma, AlIdrissi, Eman, Siegmund, Daniela, Wajant, Harald, Kumararatne, Dinakantha, AlZahrani, Mofareh S, Arkwright, Peter D, Abinun, Mario, Doffinger, Rainer, Nejentsev, Sergey

“…RIPK1 (receptor-interacting serine/threonine kinase 1) is a master regulator of signaling pathways leading to inflammation and cell death and is of medical…”
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Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor by Fischer, Roman, Wajant, Harald, Kontermann, Roland, Pfizenmaier, Klaus, Maier, Olaf

“…Tumor necrosis factor (TNF) and its receptors TNFR1 and TNFR2 have pleiotropic effects in neurodegenerative disorders. For example, while TNFR1 mediates…”
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Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis by Siegmund, Daniela, Kums, Juliane, Ehrenschwender, Martin, Wajant, Harald

“…Macrophages express TNFR1 as well as TNFR2 and are also major producers of tumor necrosis factor (TNF), especially upon contact with pathogen-associated…”
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Targeting fibroblast growth factor (FGF)-inducible 14 (Fn14) for tumor therapy by Zaitseva, Olena, Hoffmann, Annett, Otto, Christoph, Wajant, Harald

“…Fibroblast growth factor-inducible 14 (Fn14) is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and is activated by its ligand…”
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Basic characterization of antibodies targeting receptors of the tumor necrosis factor receptor superfamily by Zaitseva, Olena, Anany, Mohamed, Wajant, Harald, Lang, Isabell

“…Many new immunotherapeutic approaches aim on the stimulatory targeting of receptors of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) using…”
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Editorial: TNFRSF agonists: mode of action and therapeutic opportunities by Obermajer, Nataša, Zwolak, Adam, Wajant, Harald

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Expression of Tumor Necrosis Factor Receptor 2 Characterizes TLR9-Driven Formation of Interleukin-10-Producing B Cells by Ticha, Olga, Moos, Lukas, Wajant, Harald, Bekeredjian-Ding, Isabelle

“…B cell-derived interleukin-10 (IL-10) production has been described as a hallmark for regulatory function in B lymphocytes. However, there is an ongoing debate…”
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Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist by Kucka, Kirstin, Lang, Isabell, Zhang, Tengyu, Siegmund, Daniela, Medler, Juliane, Wajant, Harald

“…In the early 1990s, it has been described that LTα and LTβ form LTα 2 β and LTαβ 2 heterotrimers, which bind to TNFR1 and LTβR, respectively. Afterwards, the…”
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A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death by Fischer, Roman, Maier, Olaf, Siegemund, Martin, Wajant, Harald, Scheurich, Peter, Pfizenmaier, Klaus

“…Tumor necrosis factor (TNF) plays a dual role in neurodegenerative diseases. Whereas TNF receptor (TNFR) 1 is predominantly associated with neurodegeneration,…”
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Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies by Lang, Isabell, Füllsack, Simone, Wajant, Harald

“…Progranulin (PGRN) is a secreted anti-inflammatory protein which can be processed by neutrophil proteases to various granulins. It has been reported that at…”
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Fn14 and TNFR2 as regulators of cytotoxic TNFR1 signaling by Siegmund, Daniela, Zaitseva, Olena, Wajant, Harald

“…Tumor necrosis factor (TNF) receptor 1 (TNFR1), TNFR2 and fibroblast growth factor-inducible 14 (Fn14) belong to the TNF receptor superfamily (TNFRSF). From a…”
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