Search Results - "Waise, Sara"

Characterising cancer-associated fibroblast heterogeneity in non-small cell lung cancer: a systematic review and meta-analysis by Irvine, Andrew F., Waise, Sara, Green, Edward W., Stuart, Beth, Thomas, Gareth J.

“…Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with evidence suggesting they represent a heterogeneous population…”
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Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer by Hanley, Christopher J., Waise, Sara, Ellis, Matthew J., Lopez, Maria A., Pun, Wai Y., Taylor, Julian, Parker, Rachel, Kimbley, Lucy M., Chee, Serena J., Shaw, Emily C., West, Jonathan, Alzetani, Aiman, Woo, Edwin, Ottensmeier, Christian H., Rose-Zerilli, Matthew J. J., Thomas, Gareth J.

“…Fibroblasts are poorly characterised cells that variably impact tumour progression. Here, we use single cell RNA-sequencing, multiplexed immunohistochemistry…”
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A non-linear optimisation method to extract summary statistics from Kaplan-Meier survival plots using the published P value by Irvine, Andrew F, Waise, Sara, Green, Edward W, Stuart, Beth

“…Meta-analyses of studies evaluating survival (time-to-event) outcomes are a powerful technique to assess the strength of evidence for a given disease or…”
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A genetic model for central chondrosarcoma evolution correlates with patient outcome by Cross, William, Lyskjær, Iben, Lesluyes, Tom, Hargreaves, Steven, Strobl, Anna-Christina, Davies, Christopher, Waise, Sara, Hames-Fathi, Shadi, Oukrif, Dahmane, Ye, Hongtao, Amary, Fernanda, Tirabosco, Roberto, Gerrand, Craig, Baker, Toby, Barnes, David, Steele, Christopher, Alexandrov, Ludmil, Bond, Gareth, Cool, Paul, Pillay, Nischalan, Van Loo, Peter, Flanagan, Adrienne M

“…Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to…”
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An Optimized Method to Isolate Human Fibroblasts from Tissue for ex vivo Analysis by Waise, Sara, Parker, Rachel, Rose-Zerilli, Matthew J J, Layfield, David M, Wood, Oliver, West, Jonathan, Ottensmeier, Christian H, Thomas, Gareth J, Hanley, Christopher J

“…Despite their involvement in many physiological and pathological processes, fibroblasts remain a poorly-characterized cell type. Analysis of primary…”
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Thyroid paraganglionoma by Waise, Sara, Jogai, Sanjay

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Reducing the incidence of post-dural puncture headache by Waise, Sara, Gannon, David

“…First reported in 1898, post-dural puncture headache (PDPH) remains a significant clinical issue. Here, we present a brief case history and a summary of the…”
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Aneuploidy and complex genomic rearrangements in cancer evolution by Baker, Toby M, Waise, Sara, Tarabichi, Maxime, Van Loo, Peter

“…Mutational processes that alter large genomic regions occur frequently in developing tumors. They range from simple copy number gains and losses to the…”
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Abstract 3762: Single-cell analysis of cancer-associated fibroblast heterogeneity in non-small cell lung cancer: Mapping molecular phenotypes in tumors by Waise, Sara, Hanley, Christopher J., Parker, Rachel, Ottensmeier, Christian H., Rose-Zerilli, Matthew, Thomas, Gareth J.

“…Abstract This work aims to characterise the heterogeneity and spatial relationships of the cancer-associated fibroblast (CAF) population in non-small cell lung…”
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Characterising Cancer-Associated Fibroblast Heterogeneity in Non-Small Cell Lung Cancer : Relating Molecular Phenotype to Function by Waise, Sara

“…Despite recent therapeutic advances, non-small cell lung cancer (NSCLC) remains the leading cause of cancer death worldwide. To improve survival outcomes in…”
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Abstract 5084: Characterizing heterogeneity in the cancer-associated fibroblast population in non-small cell lung cancer: Relating phenotype to function by Waise, Sara, Hanley, Christopher, Parker, Rachel, Rose-Zerilli, Matthew, Ottensmeier, Christian, Thomas, Gareth

“…Abstract The aim of this work is to examine the heterogeneity in the cancer-associated fibroblast (CAF) population in non-small cell lung cancer through…”
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An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing by Waise, Sara, Parker, Rachel, Rose-Zerilli, Matthew J. J., Layfield, David M., Wood, Oliver, West, Jonathan, Ottensmeier, Christian H., Thomas, Gareth J., Hanley, Christopher J.

“…Single-cell RNA sequencing (scRNA-Seq) provides a valuable platform for characterising multicellular ecosystems. Fibroblasts are a heterogeneous cell type…”
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Abstract PO-039: Spatially discrete signalling niches regulate fibroblast heterogeneity in human lung cancer by Hanley, Christopher Jon, Waise, Sara, Rachel, Parker, Lopez, Maria-Antoinette, Taylor, Julian, Kimbley, Lucy, West, Jonathon, Ottensmeier, Christian, Rose-Zerilli, Mat, Thomas, Gareth

“…Abstract In this study we set out to define the prominent fibroblast subpopulations found in human non-small cell lung cancer. Fibroblasts are functionally…”
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Abstract 4337: Illuminating the complex rearrangement landscape of sarcoma by Waise, Sara, Lesluyes, Tom, Demeulemeester, Jonas, Tarabichi, Maxime, Flanagan, Adrienne, Pillay, Nischalan, Van Loo, Peter

“…Abstract Structural rearrangements and in particular, gene fusions, are key mutational processes in bone and soft tissue tumors, used for both disease…”
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Reducing the incidence of post-dural puncture headache by Waise, Sara, Gannon, David

“…First reported in 1898, post-dural puncture headache (PDPH) remains a significant clinical issue. Here, we present a brief case history and a summary of the…”
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Abstract 4340: Profiling the evolutionary history of giant cancer cells in sarcomas: Hopeful monsters or an evolutionary dead end by Bowes, Amy, Lesluyes, Tom, Waise, Sara, Verfaillie, Annelien, Flanagan, Adrienne, Demeulemeester, Jonas, Tarabichi, Maxime, Pillay, Nischalan, Van Loo, Peter

“…Abstract Background: As tumors evolve, they accumulate somatic mutations that serve as an archeological record of their evolutionary past. Undifferentiated…”
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Abstract 2286: Profiling the complex rearrangement landscape of sarcoma by Waise, Sara, Lesluyes, Tom, Demeulemeester, Jonas, Tarabichi, Maxime, Pillay, Nischalan, Flanagan, Adrienne M., Van Loo, Peter

“…Abstract Genomic rearrangements are key mutational processes in a number of bone and soft tissue tumors (sarcomas). These events are used for both disease…”
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